Sanyal A, Yoon S, Lencioni R. The etiology of hepatocellular carcinoma and consequences for treatment. Oncologist. 2010;15:14–22.

Article  PubMed  Google Scholar 

Rai G, Mishra S, Suman S, Shukla Y. Resveratrol improves the anticancer effects of doxorubicin in vitro and in vivo models: A mechanistic insight. Phytomedicine. 2016;23:233.

Article  CAS  PubMed  Google Scholar 

Torre A, Bray F, Siegel R, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics 2012. CA Cancer J Clin. 2015;65:87.

Article  PubMed  Google Scholar 

Llovet JM, Kelley RK, Villanueva A, Singal AG, Pikarsky E, Roayaie S, Lencioni R, Koike K, Rossi JZ, Finn RS. Hepatocellular carcinoma. Nat Rev Dis Primers. 2021;7(1):6.

Article  PubMed  Google Scholar 

Abdelfattah-Hassan A, Shalaby IS, Khater SI, El-Shetry SE, El Fadil HA, Elsayed SA. Panax ginseng is superior to vitamin E as a hepatoprotector against cyclophosphamide-induced liver damage. Complement Ther Med. 2019;46:95–102.

Article  PubMed  Google Scholar 

Gutiérrez-Rebolledo GA, Siordia-Reyes AG, Meckes-Fischer M, Jiménez-Arellanes A. Hepatoprotective properties of oleanolic and ursolic acids in antitubercular drug-induced liver damage. Asian Pac J Trop Med. 2016;9(7):644–51.

Article  PubMed  Google Scholar 

Rodeiro D, Fernandez S, Rodriguez A, Gonzalez L. La creación de empresas en el ámbito universitario: una aplicación de la teoría de los recursos. Cuadernos de Gestión. 2008;8:11–28.

Google Scholar 

Zhang L, Gu F, Chan J, Wang A, Langer R, Farokhzad O. Nanoparticles in medicine: therapeutic applications and developments. Clin Pharmacol Ther. 2008;83:76.

Article  Google Scholar 

Balbatina LA, Stolyarova OV, Kondratenko RM, Plyasunova OA, Pokrovskii AG. L.A.Synthesis and antiviral activity of 18α-glycyrrhizic acid and its esters. Pharm Chem J. 2010;44(6):299–302.

Article  Google Scholar 

Salmine A, Lehtonen M, Suuronen T, Kaarniranta K, Huuskonen J. Terpenoids: natural inhibitors of NK-κB signaling with anti-inflammatory and anticancer potential. Cell Mol Life Sci. 2008;65(19):2979–99.

Article  Google Scholar 

Kim KJ, Choi JS, Kim KW, Jeong JW. The anti-angiogenic activities of glycyrrhizic acid in tumor progression. Phytother Res. 2013;27(6):841–6.

Article  PubMed  Google Scholar 

Graebin CS. The pharmacological activities of glycyrrhizinic acid (“Glycyrrhizin”) and glycyrrhetinic acid. In: Mérillon JM, Ramawat KG, editors. Sweeteners. Reference Series in Phytochemistry. Springer, Cham., Switzerland, 2018:245–61.

Groen J, Pelser H, Frenkel M, Kamminga CE, et al. Effect of glycyrrhizinic acid on the electrolyte metabolism in Addison’s disease. J Clin Investig. 1951;31(1):87–91.

Article  Google Scholar 

Ruiz MCR, Amer H, Stanetty C, Beseda I, Czollner L, Shah P, Jordis U, Kueenburg B, ClaBen-Houben D, Hofinger A, Kosma P. Efficient synthesis of glycyrrhetinic acid glycoside/glucuronide derivatives using silver zeolite as promoter. Carbohyd Res. 2009;344(9):1063–71.

Article  CAS  Google Scholar 

Amagaya S, Sugishita E, Ogihara Y, Ogawa S, Okada K, Aizawa T. Comparative studies of the stereoisomers of glycyrrhetinic acid on anti-inflammatory activities. J Pharmacobiodyn. 1984;7(12):923–8.

Article  CAS  PubMed  Google Scholar 

Davis EA, Morris DJ. Medicinal Uses of Licorice Through the Millennia: the Good and Plenty of It. Mol Cell Endocrinol. 1991;78(1–2):1–6.

Article  CAS  PubMed  Google Scholar 

Fiore C, Eisenhut M, Ragazzi E, Zanchin G, Armanini D. A History of the Therapeutic Use of Liquorice in Europe. J Ethnopharmacol. 2005;99(3):317–24.

Article  PubMed  PubMed Central  Google Scholar 

MonteirodoNascimiento MH, RibeirodeAraújo D. Exploring the Pharmacological Potential of Glycyrrhizic Acid: From Therapeutic Applications to Trends in Nanomedicine. Future Pharmacol. 2022;2(1):1–15.

Article  Google Scholar 

Bharali DJ, Mousa SA. Emerging nanomedicines for early cancer detection and improved treatment: Current perspective and future promise. Pharmacol Ther. 2010;128:324–35.

Article  CAS  PubMed  Google Scholar 

Gindy ME, Prud’homme RK. Multifunctional nanoparticles for imaging, delivery and targeting in cancer therapy. Expert Opin Drug Deliv. 2009;6(8):865–78.

Article  CAS  PubMed  Google Scholar 

Perioli L, Ambrogi V, Di Nauta L, Nocchetti M, Rossi C. Effects of hydrotalcite-like nanostructured compounds on biopharmaceutical properties and release of BCS class II drugs: The case of flurbiprofen. Appl Clay Sci. 2011;51:407–13.

Article  CAS  Google Scholar 

Arcoa M, Gutiérrez S, Martína C, Rivesa V. Synthesis and characterization of layered double hydroxides (LDH) intercalated with non-steroidal anti-inflammatory drugs (NSAID). J Solid State Chem. 2004;177:3954–62.

Article  Google Scholar 

Nakayama H, Hatakeyama A, Tsuhako M. Encapsulation of nucleotides and DNA into Mg-Al layered double hydroxide. Int J Pharm. 2010;393:105–12.

Article  Google Scholar 

Rives V. Layered Double Hydroxides: Present and Future. New York: Nova Science Publishers Inc; 2001.

Google Scholar 

Duan X, Evans DG. Layered double hydroxides. Structure and bonding. Springer-Verlag Berlin Heidelberg, Germany, 2006, p. 234.

Cavani F, Trifiró F, Vaccari A. Hydrotalcite-like anionic clays: preparation, properties and applications. Catal Today. 1991;11:173–301.

Article  CAS  Google Scholar 

Choi SJ, Choy JH. Effect of physico-chemical parameters on the toxicity of inorganic nanoparticles. J Mater Chem. 2011;21:5547–54.

Article  CAS  Google Scholar 

Choi SJ, Choy JH. Layered double hydroxide nanoparticles as target-specific delivery carriers: Uptake mechanism and toxicity. Nanomedicine. 2011;6:803–14.

Article  CAS  PubMed  Google Scholar 

Rives V, Arco M, Martín C. Intercalation of drugs in layered double hydroxides and their controlled release: A review. Appl Clay Sci. 2014;88:239–69.

Article  Google Scholar 

Wenji J, Dongki L, Yukwon J, Dae-Hwan P. Biocompatible Hydrotalcite Nanohybrids for Medical Functions. Minerals. 2020;10:172.

Google Scholar 

Wiyantoko B, Kurniawati P, Purbaningtias TE, Fatimah I. Synthesis and Characterization of Hydrotalcite at Different Mg/Al Molar Ratios. Procedia Chemistry. 2015;17:21–6.

Article  CAS  Google Scholar 

Wang Q, Wu Z, Huang Tay H, Chen L, Liu Y, Chang J, Zhong Z, Luo J, Borgna A. High temperature adsorption of CO2 on Mg–Al hydrotalcite: Effect of the charge compensating anions and the synthesis pH. Catal Today. 2011;164:198–203.

Article  CAS  Google Scholar 

Kwon D, Kang JY, An S, Yang I, Jung JC. Tuning the base properties of Mg–Al hydrotalcite catalysts using their memory effect. J Energy Chem. 2020;45:229–36.

Article  Google Scholar 

Trujillo R, Labajos FM, Rives V. Hydrotalcites, a rapid survey on the very recent synthesis and applications procedures. Appl Clay Sci. 2023;238(15):106927.

Article  Google Scholar 

Yang G, Lin W, Lai H, Tong J, Lei J, Yuan M, Zhang Y, Cuia C. Understanding the relationship between particle size and ultrasonic treatment during the synthesis of metal nanoparticles. Ultrason Sonochemistry. 2021;73:105497.

Article  CAS  Google Scholar 

Dumortier G, Grossiord J, Agnely F, Chaumeil J. A Review of Poloxamer 407 Pharmaceutical and Pharmacological Characteristics. Pharm Res. 2006;23:2709–28.

Article  CAS  PubMed  Google Scholar 

Almeida M, Magalhães M, Veiga F, Figueiras A. Poloxamers, poloxamines and polymeric micelles: Definition, structure and therapeutic applications in cancer. J Polym Res. 2018;25:31.

Article  Google Scholar 

Bo-Kyung K, Gyeong-Hyeon G, Tomohiko O, Jae-Min O. Effect of particle size and local disorder on specific surface area of layered double hydroxides upon calcination-reconstruction. J Solid State Chem. 2018;263:60–4.

Article  Google Scholar 

Ćirin D, Veljko K, Mihalj P. Properties of poloxamer 407 and polysorbate mixed micelles: Influence of polysorbate hydrophobic chain. J Ind Eng Chem. 2017;47:194–201.

Article  Google Scholar 

Gorjian H, Mihankhah P, Khaligh NG. Influence of tween nature and type on physicochemical properties and stability of spearmint essential oil (Mentha spicata L.). J Mol Liq Stabilized Basil Seed Mucilage Nanoemulsion. 2022;359:119379.

CAS  Google Scholar 

Freitas C, Muller RH. Effect of light and temperature on zeta potential and physical stability in solid lipid nanoparticle (SLN™) dispersions. Int J Pham. 1988;168(2):221–9.