Ciaramitaro P, et al. Traumatic peripheral nerve injuries: epidemiological findings, neuropathic pain and quality of life in 158 patients. J Peripher Nerv Syst. 2010;15(2):120–7.
Abdolmaleki A, et al. Preparation of acellular sciatic nerve scaffold and it’s mechanical and histological properties for use in peripheral nerve regeneration. Tehran Univ Med J TUMS Publ. 2019;77(2):115–22.
Rotshenker S. Traumatic injury to peripheral nerves. Nerves and nerve injuries. 2015. pp. 611-628. https://doi.org/10.1016/B978-0-12-802653-3.00088-9.
Ghayour M-B, Abdolmaleki A, Behnam-Rassouli M. The effect of memantine on functional recovery of the sciatic nerve crush injury in rats. Turk Neurosurg. 2017;27(4):641–7.
Hussain G, et al. Current status of therapeutic approaches against peripheral nerve injuries: a detailed story from injury to recovery. Int J Biol Sci. 2020;16(1):116.
Article CAS PubMed PubMed Central Google Scholar
Ghayour MB, Abdolmaleki A, Fereidoni M. Role of extracellular matrix in peripheral nerve regeneration process. 2015. https://doi.org/10.7150/ijbs.35653.
Mamidi N, et al. Fabrication of gelatin-poly (epichlorohydrin-co-ethylene oxide) fiber scaffolds by Forcespinning® for tissue engineering and drug release. 2017; 7(4):913-921. https://doi.org/10.1557/mrc.2017.117.
Mamidi N, et al. Carbonaceous nanomaterials incorporated biomaterials: the present and future of the flourishing field. 2022;243:110150. https://doi.org/10.1016/j.compositesb.2022.110150.
Souza NM, et al. Revisiting the role of biologically active natural and synthetic compounds as an intervention to treat injured nerves. Mol Neurobiol. 2021;58:4980–98.
Article CAS PubMed Google Scholar
Yow Y-Y, et al. Therapeutic potential of complementary and alternative medicines in peripheral nerve regeneration: a systematic review. Cells. 2021;10(9):2194.
Article CAS PubMed PubMed Central Google Scholar
Abdolmaleki A, Ghayour M-B, Behnam-Rassouli M. Protective effects of acetyl-l-carnitine against serum and glucose deprivation-induced apoptosis in rat adipose-derived mesenchymal stem cells. Cell Tissue Banking. 2020;21:655–66.
Article CAS PubMed Google Scholar
Vimala K, Kannan S. Phyto-drug conjugated nanomaterials enhance apoptotic activity in cancer. Adv Protein Chem Struct Biol. 2021;125:275–305.
Article CAS PubMed Google Scholar
Bischoff-Kont I, Fürst R. Benefits of ginger and its constituent 6-shogaol in inhibiting inflammatory processes. Pharmaceuticals. 2021;14(6):571.
Article CAS PubMed PubMed Central Google Scholar
Shahrajabian MH, Sun W, Cheng Q. Clinical aspects and health benefits of ginger (Zingiber officinale) in both traditional Chinese medicine and modern industry. Acta Agric Scand Section B—Soil Plant Sci. 2019;69(6):546–56.
Kawamoto Y, et al. Prevention of allergic rhinitis by ginger and the molecular basis of immunosuppression by 6-gingerol through T cell inactivation. J Nutr Biochem. 2016;27:112–22.
Article CAS PubMed Google Scholar
Funk JL, et al. Comparative effects of two gingerol-containing Zingiber officinale extracts on experimental rheumatoid arthritis. J Nat Prod. 2009;72(3):403–7.
Article CAS PubMed PubMed Central Google Scholar
Son MJ, Miura Y, Yagasaki K. Mechanisms for antidiabetic effect of gingerol in cultured cells and obese diabetic model mice. Cytotechnology. 2015;67:641–52.
Article CAS PubMed Google Scholar
Samad MB, et al. [6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic β-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Leprdb/db type 2 diabetic mice. BMC Complement Altern Med. 2017;17(1):1–13.
Liu Y, et al. 6-Gingerol attenuates microglia-mediated neuroinflammation and ischemic brain injuries through Akt-mTOR-STAT3 signaling pathway. Eur J Pharmacol. 2020;883:173294.
Article CAS PubMed Google Scholar
Adetuyi BO, Farombi EO. 6-Gingerol, an active constituent of ginger, attenuates lipopolysaccharide-induced oxidation, inflammation, cognitive deficits, neuroplasticity, and amyloidogenesis in rat. J Food Biochem. 2021;45(4):e13660.
Article CAS PubMed Google Scholar
Kongsui R, Jittiwat J. Ameliorative effects of 6-gingerol in cerebral ischemia are mediated via the activation of antioxidant and anti-inflammatory pathways. Biomed Rep. 2023;18(4):1–10.
Farombi EO, et al. Neuroprotection by ginger and its components in neurodegenerative diseases. In: Natural molecules in neuroprotection and neurotoxicity. Elsevier; 2024. p. 1525–43.
Angelopoulou E, et al. Elucidating the beneficial effects of ginger (Zingiber officinale Roscoe) in Parkinson’s disease. ACS Pharmacol Transl Sci. 2022;5(10):838–48.
Article CAS PubMed PubMed Central Google Scholar
Wang S, et al. Biological properties of 6-gingerol: a brief review. Nat Prod Commun. 2014;9(7):1934578X1400900736.
Sarikcioglu L, Demirel B, Utuk A. Walking track analysis: an assessment method for functional recovery after sciatic nerve injury in the rat. Folia Morphol. 2009;68(1):1–7.
Cheah M, Fawcett JW, Andrews MR. Assessment of thermal pain sensation in rats and mice using the Hargreaves test. Bio-Protoc. 2017;7(16):e2506–e2506.
PubMed PubMed Central Google Scholar
Schulz A, et al. In vivo electrophysiological measurements on mouse sciatic nerves. JoVE (J Vis Exp). 2014;86: e51181.
Scipio FD, et al. A simple protocol for paraffin-embedded myelin sheath staining with osmium tetroxide for light microscope observation. Microsc Res Tech. 2008;71(7):497–502.
Campbell WW. Evaluation and management of peripheral nerve injury. Clin Neurophysiol. 2008;119(9):1951–65.
Bhandari P. Management of peripheral nerve injury. J Clin Orthop Trauma. 2019;10(5):862–6.
Article CAS PubMed PubMed Central Google Scholar
Arcusa R, et al. Potential role of ginger (Zingiber officinale Roscoe) in the prevention of neurodegenerative diseases. Front Nutr. 2022;9:809621.
Article PubMed PubMed Central Google Scholar
Simon A, et al. Blood-brain barrier permeability study of ginger constituents. J Pharm Biomed Anal. 2020;177: 112820.
Article CAS PubMed Google Scholar
Young H-Y, et al. Analgesic and anti-inflammatory activities of [6]-gingerol. J Ethnopharmacol. 2005;96(1–2):207–10.
Article CAS PubMed Google Scholar
Morera E, et al. Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators. Bioorg Med Chem Lett. 2012;22(4):1674–7.
Article CAS PubMed Google Scholar
Sagalajev B, et al. Oxidative stress in the amygdala contributes to neuropathic pain. Neuroscience. 2018;387:92–103.
Article CAS PubMed Google Scholar
Ju S-A, et al. Pretreatment with 6-gingerol ameliorates sepsis-induced immune dysfunction by regulating the cytokine balance and reducing lymphocyte apoptosis. Oxidative Med Cell Longev. 2021;2021. https://doi.org/10.1155/2021/5427153
Russo R, et al. A new ginger extract characterization: immunomodulatory, antioxidant effects and differential gene expression. Food Biosci. 2023;53:102746.
Lee T-Y, et al. 6-Gingerol inhibits ROS and iNOS through the suppression of PKC-α and NF-κB pathways in lipopolysaccharide-stimulated mouse macrophages. Biochem Biophys Res Commun. 2009;382(1):134–9.
Article CAS PubMed Google Scholar
Zhang F-L, et al. 6-Gingerol attenuates macrophages pyroptosis via the inhibition of MAPK signaling pathways and predicts a good prognosis in sepsis. Cytokine. 2020;125:154854.
Comments (0)