Introduction To promote holistic learning about Antimicrobial Resistance (AMR), catalyze multidisciplinary engagement, and innovative AMR interventions, it is important that learning goes beyond the classroom and students embrace different extracurricular interventions. This study aimed to determine knowledge, attitudes, and motivations influencing medical students’ engagement in AMR Club Initiatives at Busitema University in Uganda. Methodology This was descriptive cross-sectional study conducted at Busitema University among undergraduate student pursuing Bachelors of Medicine and Surgery, Bachelor of Nursing, and Bachelor of Science in Anesthesia and Critical care. A semi structured pre-tested questionnaire was shared among the study participants. Bloom cut-off method was used to analyse the knowledge of the participants, chi square test used for bivariate analysis and multivariable logistic regression used for determining factors independently associated to students' engagement in AMR club activities. Results 71.5% of the 193 students had sufficient knowledge (determined using Bloom’s cutoff categories from 60% and above as sufficient and below 60% as insufficient)  on AMR with an average score of 68.18% (SD= ±16.12). 90% of participants recognized the significance of incorporating AMR within their curriculum, and 87.5% appreciated the need for training AMR using a One Health ApproachThe most common reasons why students engaged in extracurricular efforts to address AMR such as forming AMR clubs were found to be; influence from peers (n= 42), university support (n=35), and inspiration from peer mentors’ work (n=35). Conclusion The students were found to have a high level of knowledge and positive attitudes towards AMR but reported the need for further in-depth training. Extra-curricular engagement such as participation in an AMR Club was found to positively influence students’ engagement in AMR interventions.

The authors have declared no competing interest.

The author(s) received no specific funding for this work.

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The study was conducted according to the Declaration of Helsinki. Ethical approval was sought and obtained from Busitema University Research Ethics committee under the reference number (BUFHS-2023-104) . Written informed consent was obtained from the participants before recruitment into the study. The data collected was kept in a locked folder in the computer which was accessible only to the investigators.

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