Aim: This study aimed to assess the correlation between the PLR curves of 25 healthy volunteers, generated with the MindMirror mobile telephone application, with PLR data from a dedicated clinical pupillometer. Materials & methods: Paired pupillary light reflex curves were recorded from 25 healthy volunteers using the MindMirror mobile telephone application, and a Neuroptics NPi 200 clinical pupillometer. The curves were analysed for correlation using a Pearson correlation coefficient across both curve sets. Results: Close correlation was demonstrated between all parameters except maximum and mean pupillary constriction velocity. These values were consistently lower in the MindMirror derived curves and may be explained by the intensity of the light stimulus available from a mobile telephone being significantly less that that used by the clinical pupillometer. Conclusion: A mobile telephone equipped with a MindMirror mobile phone application may provide a reliable, low cost and widely available alternative to a clinical pupillometer in the assessment of the pupillary light reflex.

Non-financial interests: Professor Middleton and Dr Davies act as unpaid medical advisors to MindMirror inc. Financial interests: Mr. Buzytsky is a cofounder and CTO of MindMirror, Inc.

This study did not receive any funding

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Yes

The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

This study was performed in line with the principles of the Declaration of Helsinki, and following approval from the South Western Sydney Local Health District (SWSLHD) Human Research Ethics Application (HREA), under the title "2023/ETH00741: The Australian Pupillary Light Response Registry (APLRR)". Informed consent was obtained from all volunteers.

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Yes

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I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable.

Yes

All data produced in the present study are available upon reasonable request to the authors