Stroke recognition in medical emergency calls:A novel sensitivity definition as basis for developing AI decision support

Abstract

Background The sensitivity of emergency medical communication centers (EMCC) for stroke detection varies widely. However, few studies offer detailed insights into the entirety of prehospital pathways in patients with stroke. Therefore, this study aimed to lay the foundation for artificial intelligence (AI) decision support tools in EMCCs by exploring their ability to detect strokes in medical emergency calls, describe a novel method for stroke sensitivity calculation in the EMCC, and identify factors associated with stroke recognition during a call.

Methods In total, 1,164 patients with stroke in the catchment area of Bergen EMCC in 2018 and 2019 were included, and a dataset from the EMCC was established manually and linked with data from the Norwegian Stroke Registry (NSR) for analysis. Descriptive statistics, Chi-square test for categorical variables, Mann–Whitney U test for continuous variables, and multivariate logistic regression (LR) were performed on data obtained from patients primarily assessed by EMCC (n=838).

Results Using a novel method, we found a stroke detection sensitivity of 76.8% in our study, compared to the 63.4% when using the traditional sensitivity detection method. LR analysis showed a positive association between stroke suspicion and ischemic strokes (odds ratio [OR]=0.317 [0.209–0.481]; p<0,001, with ischemic stroke as the reference) and wake-up strokes (OR=1.716 [1.110–2.653]; p=0.015). Among the NSR symptoms, only aphasia/dysarthria was positively associated with stroke suspicion (OR=1.600 [1.087–2.353]; p=0.017), while leg paresis (OR=0.609 [0.390–0.953]; p=0.009) and vertigo (OR=0.376 [0.204–0.694]; p=0.002) were negatively associated.

Conclusions This study introduced a novel and more accurate method for calculating EMCC stroke sensitivity, which is relevant for developing decision support tools, such as AI. Moreover, we identified factors of particular interest for future EMCC research that are relevant to developing AI decision-support tools.

Competing Interest Statement

The authors have declared no competing interest.

Clinical Trial

https://clinicaltrials.gov/study/NCT04648449

Funding Statement

AISMEC has received funding from The Research Council of Norway (grant number 331965) and The Laerdal Foundation, in addition to departmental funding from Bergen Health Trust. Emil Iversen, first author, also received a grant in support to his PhD from Laerdal Fourndation.

Author Declarations

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Yes

The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

The study was approved by the Regional Committee for Medical Research Ethics Western Norway, REK West (108573), and the Data Protection Officers at Bergen and Haraldsplass Health trusts (1612-1612). All study participants consented passively to participate in the study and were given the option to withdraw from the study by postal letter.

I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.

Yes

I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

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I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable.

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Data Availability

All data is saved on a secure, restricted access research server at Haukeland University Hospital. Anonymized data can be made available upon reasonable request.

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