J Reconstr Microsurg
DOI: 10.1055/a-2404-7819
Alec D. Simoni
1
The University of Arizona College of Medicine, Phoenix, Arizona
,
Justin E. Bird
2
Department of Orthopedic Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas
,
Patrick P. Lin
2
Department of Orthopedic Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas
,
Laurence D. Rhines
3
Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas
,
Alexander F. Mericli
4
Department of Plastic Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas
› Author Affiliations
Financial Disclosure Statement Alexander F. Mericli, MD:
1. Mentor Worldwide, LLC: Scientific Advisory Board Member and Consultant.
2. Allergan, Inc: Consultant.
3. Destiny Pharma, PLC: Consultant.
Laurence Rhines, MD:
1. Stryker: Consultant.
2. Icotec Medical, Inc: Consultant.
Patrick P. Lin, MD:
1. MTF: Medical Board of Trustees.
› Further Information
Also available at
Buy Article Permissions and Reprints
Abstract
Background Numerous surgical fields have embraced computer-aided design and computer-aided manufacturing (CAD/CAM), including plastic and reconstructive surgery. However, most of the literature and clinical use pertains to reconstruction of the head and neck. Herein, we provide a case series and systematic review of the literature, documenting the use of CAD/CAM in facilitating complex microvascular free tissue transfer for reconstructions involving the extremities, pelvis, and spine (EPS).
Methods This study consisted of two components: a case series and a systematic review of the literature. For the case series, the senior author's cases that included CAD/CAM to assist microvascular free tissue transfer reconstructions of the EPS were included. For the systematic review, all PubMed-, Scopus-, and Google Scholar–indexed studies describing the use of CAD/CAM to facilitate free tissue transfer in the EPS were identified and included using PRSMA guidelines.
Results The case series identified 10 patients who received CAD/CAM-assisted microvascular reconstruction. Our systematic review identified 15 articles, representing 124 patients and 133 CAD/CAM-assisted free tissue transfers. Most authors believed that CAD/CAM facilitated a more efficient operation by shifting much of the intraoperative planning to the preoperative phase, ultimately translating to a shorter and more accurate surgery with improved function and cosmesis.
Conclusion CAD/CAM can be used to facilitate microvascular reconstruction of the EPS. Our cases series and systematic review suggest that CAD/CAM for EPS surgery may improve outcomes.
Keywords
CAD/CAM -
virtual surgical planning -
free flap -
microsurgery -
extremity -
pelvis -
spine
Publication History
Received: 22 May 2024
Accepted: 12 August 2024
Accepted Manuscript online:
27 August 2024
Article published online:
27 September 2024
© 2024. Thieme. All rights reserved.
Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA
References
1
Schendel SA,
Eisenfeld JH,
Bell WH,
Epker BN.
Superior repositioning of the maxilla: stability and soft tissue osseous relations. Am J Orthod 1976; 70 (06) 663-674
2
Resten A,
Guédon C,
Piekarski JD,
Laffite F.
3-dimensional computed tomography with model preparation before mandibular reconstruction [in French]. J Radiol 1998; 79 (09) 871-876
3
Agrawal N,
DeFazio MV,
Bird JE,
Mericli AF.
Computer-aided design and computer-aided manufacturing for pelvic tumor resection and free fibula flap reconstruction. Plast Reconstr Surg 2020; 145 (04) 889e-890e
4
Padilla PL,
Mericli AF,
Largo RD,
Garvey PB.
Computer-aided design and manufacturing versus conventional surgical planning for head and neck reconstruction: a systematic review and meta-analysis. Plast Reconstr Surg 2021; 148 (01) 183-192
5
Schmidt M,
Holzbauer M,
Kwasny O,
Huemer GM,
Froschauer III S.
3D printing for scaphoid-reconstruction with medial femoral condyle flap. Injury 2020; 51 (12) 2900-2903
6
Matros E,
Albornoz CR,
Rensberger M,
Weimer K,
Garfein ES.
Computer-assisted design and computer-assisted modeling technique optimization and advantages over traditional methods of osseous flap reconstruction. J Reconstr Microsurg 2014; 30 (05) 289-296
7
Zang CW,
Zhang JL,
Meng ZZ.
et al.
3D printing technology in planning thumb reconstructions with second toe transplant. Orthop Surg 2017; 9 (02) 215-220
8
Bettini G,
Saia G,
Valsecchi S,
Bedogni G,
Sandi A,
Bedogni A.
Three-dimensional CAD/CAM reconstruction of the iliac bone following DCIA composite flap harvest. Int J Oral Maxillofac Implants 2021; 50 (01) 32-37
9
Cai X,
Xu Y,
Yu K.
et al.
Clinical application of 3-dimensional printed navigation templates in treating femoral head osteonecrosis with pedicled iliac bone graft. Ann Plast Surg 2020; 84 (5S, Suppl 3): S230-S234
10
Dong C,
Beglinger I,
Krieg AH.
Personalized 3D-printed guide in malignant bone tumor resection and following reconstruction - 17 cases in pelvic and extremities. Surg Oncol 2022; 42: 101733
11
Ellabban MA,
Elsayed MA,
Zein AB.
et al.
Virtual planning of the anterolateral thigh free flap for heel reconstruction. Microsurgery 2022; 42 (05) 460-469
12
Garcia-Tutor E,
Romeo M,
Chae MP,
Hunter-Smith DJ,
Rozen WM.
3D volumetric modeling and microvascular reconstruction of irradiated lumbosacral defects after oncologic resection. Front Surg 2016; 3: 66
13
Houdek MT,
Matsumoto JM,
Morris JM,
Bishop AT,
Shin AY.
Technique for 3-dimesional (3D) modeling of osteoarticular medial femoral condyle vascularized grafting to replace the proximal pole of unsalvagable scaphoid nonunions. Tech Hand Up Extrem Surg 2016; 20 (03) 117-124
14
Lu H,
Peng H,
Peng Z,
Liu D,
Wu Q,
Liu R.
The application of digital design combined with 3D printing technology in skin flap transplantation for fingertip defects during the COVID-19 epidemic. BioMed Res Int 2021; 2021: 5554500
15
Schmidt M,
Holzbauer M,
Froschauer SM.
Metacarpal reconstruction with a medial femoral condyle flap based on a 3D-printed model: a case report. Case Reports Plast Surg Hand Surg 2022; 9 (01) 52-56
16
St Hilaire H,
Steele TN,
Delatte S,
Hebert CK,
Canizares O.
Metatarsal reconstruction with a fibular osteocutaneous flap: a novel approach utilizing virtual surgical planning. Plast Reconstr Surg Glob Open 2014; 2 (11) e258
17
Wang H,
Zhang Z,
Zhao J,
Du Z,
Li S,
Zhang X.
Three-dimensional computer-aided design modeling and printing for accurate toe-to-hand transplantation. J Hand Surg Am 2023; 48 (02) 198.e1-198.e11
18
Rodriguez Colon R,
Nayak VV,
Parente PEL.
et al.
The presence of 3D printing in orthopedics: a clinical and material review. J Orthop Res 2023; 41 (03) 601-613
19
Antony AK,
Chen WF,
Kolokythas A,
Weimer KA,
Cohen MN.
Use of virtual surgery and stereolithography-guided osteotomy for mandibular reconstruction with the free fibula. Plast Reconstr Surg 2011; 128 (05) 1080-1084
20
Hanasono MM,
Skoracki RJ.
Computer-assisted design and rapid prototype modeling in microvascular mandible reconstruction. Laryngoscope 2013; 123 (03) 597-604
21
Kurlander DE,
Garvey PB,
Largo RD.
et al.
The cost utility of virtual surgical planning and computer-assisted design/computer-assisted manufacturing in mandible reconstruction using the free fibula osteocutaneous flap. J Reconstr Microsurg 2023; 39 (03) 221-230
22 USFDA. Humanitarian device exemption. Accessed February 2, 2024 at
https://www.fda.gov/medical-devices/premarket-submissions-selecting-and-preparing-correct-submission/humanitarian-device-exemption
23
Ceccariglia F,
Cercenelli L,
Badiali G,
Marcelli E,
Tarsitano A.
Application of augmented reality to maxillary resections: a three-dimensional approach to maxillofacial oncologic surgery. J Pers Med 2022; 12 (12) 2047
24
Galati R,
Simone M,
Barile G,
De Luca R,
Cartanese C,
Grassi G.
Experimental setup employed in the operating room based on virtual and mixed reality: analysis of pros and cons in open abdomen surgery. J Healthc Eng 2020; 2020: 8851964
25
Onkos Surgical.
Onkos Surgical Receives FDA 510(K) Clearance for 3D Printed, Patient-Specific Pelvic Reconstruction System [press release]. Parsippany, NJ:: Onkos Surgical, Inc.; 2022
Comments (0)