Kortmann RD, Kühl J, Timmermann B, Calaminus G, Dieckmann K, Wurm R, Sörensen N, Urban C, Gö bel U, Bamberg M (2001) Actual and future strategies in interdisciplinary treatment of medulloblastomas, supratentorial PNET and intracranial germ cell tumors in childhood. Strahlenther Onkol 177:447–461. https://doi.org/10.1007/pl00002426

Article  CAS  PubMed  Google Scholar 

Merchant TE, Kun LE, Krasin MJ, Wallace D, Chintagumpala MM, Woo SY, Ashley DM, Sexton M, Kellie SJ, Ahern V, Gajjar A (2008) Multi-institution prospective trial of reduced-dose craniospinal irradiation (23.4 Gy) followed by conformal posterior fossa (36 Gy) and primary site irradiation (55.8 Gy) and dose-intensive chemotherapy for average-risk medulloblastoma. Int J Radiat Oncol Biol Phys 70:782–787. https://doi.org/10.1016/j.ijrobp.2007.07.2342

Article  PubMed  Google Scholar 

Paulino AC, Lobo M, Teh BS, Okcu MF, South M, Butler EB, Su J, Chintagumpala M (2010) Ototoxicity after intensity-modulated radiation therapy and cisplatin-based chemotherapy in children with medulloblastoma. Int J Radiat Oncol Biol Phys 78:1445–1450. https://doi.org/10.1016/j.ijrobp.2009.09.031

Article  CAS  PubMed  Google Scholar 

Scobioala S, Parfitt R, Matulat P, Kittel C, Ebrahimi F, Wolters H, Zehnhoff-Dinnesen AA, Eich HT (2017) Impact of radiation technique, radiation fraction dose, and total cisplatin dose on hearing: retrospective analysis of 29 medulloblastoma patients. Strahlenther Onkol 193:910–920. https://doi.org/10.1007/s00066-017-1205-y

Article  PubMed  Google Scholar 

Lannering B, Rutkowski S, Doz F, Pizer B, Gustafsson G, Navajas A, Massimino M, Reddingius R, Benesch M, Carrie C, Taylor R, Gandola L, Björk-Eriksson T, Giralt J, Oldenburger F, Pietsch T, Figarella-Branger D, Robson K, Forni M, Clifford SC, Warmuth-Metz M, Von Hoff K, Faldum A, Mosseri V, Kortmann R (2012) Hyperfractionated versus conventional radiotherapy followed by chemotherapy in standard-risk medulloblastoma: Results from the randomized multicenter HIT-SIOP PNET 4 trial. J Clin Oncol 30:3187–3193. https://doi.org/10.1200/JCO.2011.39.8719

Article  PubMed  Google Scholar 

Schell MJ, McHaney VA, Green AA, Kun LE, Hayes FA, Horowitz M, Meyer WH (1989) Hearing loss in children and young adults receiving cisplatin with or without prior cranial irradiation. J Clin Oncol 7:754–760. https://doi.org/10.1200/JCO.1989.7.6.754

Article  CAS  PubMed  Google Scholar 

Wong KL, Song TT, Wee J, Fook-Chong SMC, De YW (2006) Sensorineural hearing loss after radiotherapy and chemoradiotherapy: a single, blinded, randomized study. J Clin Oncol 24:1904–1909. https://doi.org/10.1200/JCO.2005.05.0096

Article  Google Scholar 

Chen WC, Jackson A, Budnick AS, Pfister DG, Kraus DH, Hunt MA, Stambuk H, Levegrun S, Wolden SL (2006) Sensorineural hearing loss in combined modality treatment of nasopharyngeal carcinoma. Cancer 106:820–829. https://doi.org/10.1002/cncr.21683

Article  PubMed  Google Scholar 

Scobioala S, Parfitt R, Matulat P, Byrne J, Langer T, Troschel FM, Hesping AE, Clemens E, Kaatsch P, Grabow D, Kaiser M, Spix C, Kremer LC, Calaminus G, Baust K, Kuehni CE, Weiss A, Strebel S, Kuonen R, Elsner S, Haupt R, Garré M, Gruhn B, Kepak T, Kepakova K, Winther JF, Kenborg L, Rechnitzer C, Hasle H, Kruseova J, Luks A, Lackner H, Bielack S, Beck J, Jürgens H, van den Heuvel-Eibrink MM, Zolk O, Eich HT, am Zehnhoff-Dinnesen A (2023) The impact of the temporal sequence of cranial radiotherapy and platin-based chemotherapy on hearing impairment in pediatric and adolescent CNS and head-and-neck cancer patients: a report from the pancareLIFE consortium. Int J Cancer. https://doi.org/10.1002/ijc.34732

Article  PubMed  Google Scholar 

Kinclová I, Hajtmanová E, Matula P, Balentová S, Muríň P, Ďuroška M, Kozlíková K (2020) Model-based calculation of thyroid gland normal tissue complication probability in head and neck cancer patients after radiation therapy. Strahlenther Onkol 196:561–568. https://doi.org/10.1007/s00066-020-01579-y

Article  PubMed  Google Scholar 

Beddok A, Maynadier X, Krhili S, Ala Eddine C, Champion L, Chilles A, Goudjil F, Zefkili S, Amessis M, Choussy O, Le Tourneau C, Buvat I, Créhange G, Carton M, Calugaru V (2023) Predictors of toxicity after curative reirradiation with intensity modulated radiotherapy or proton therapy for recurrent head and neck carcinoma: new dose constraints for pharyngeal constrictors muscles and oral cavity. Strahlenther Onkol 199:901–909. https://doi.org/10.1007/s00066-023-02080-y

Article  PubMed  Google Scholar 

Pepper NB, Stummer W, Eich HT (2022) The use of radiosensitizing agents in the therapy of glioblastoma multiforme—a comprehensive review. Strahlentherapie Onkol 198:507–526

Article  Google Scholar 

Bhandare N, Antonelli PJ, Morris CG, Malayapa RS, Mendenhall WM (2007) Ototoxicity after radiotherapy for head and neck tumors. Int J Radiat Oncol Biol Phys 67:469–479. https://doi.org/10.1016/j.ijrobp.2006.09.017

Article  PubMed  Google Scholar 

Hua C, Bass JK, Khan R, Kun LE, Merchant TE (2008) Hearing loss after radiotherapy for pediatric brain tumors: effect of cochlear dose. Int J Radiat Oncol Biol Phys 72:892–899. https://doi.org/10.1016/j.ijrobp.2008.01.050

Article  PubMed  Google Scholar 

Bhandare N, Jackson A, Eisbruch A, Pan CC, Flickinger JC, Antonelli P, Mendenhall WM (2010) Radiation therapy and hearing loss. Int J Radiat Oncol Biol Phys. https://doi.org/10.1016/j.ijrobp.2009.04.096

Article  PubMed  PubMed Central  Google Scholar 

Huang E, Teh BS, Strother DR, Davis QG, Chiu JK, Lu HH, Carpenter LS, Mai WY, Chintagumpala MM, South M, Grant WH, Butler EB, Woo SY (2002) Intensity-modulated radiation therapy for pediatric medulloblastoma: early report on the reduction of ototoxicity. Int J Radiat Oncol Biol Phys 52:599–605. https://doi.org/10.1016/S0360-3016(01)02641-4

Article  PubMed  Google Scholar 

Knight KRG, Kraemer DF, Neuwelt EA (2005) Ototoxicity in children receiving platinum chemotherapy: underestimating a commonly occurring toxicity that may influence academic and social development. J Clin Oncol 23:8588–8596. https://doi.org/10.1200/JCO.2004.00.5355

Article  PubMed  Google Scholar 

Skinner R, Pearson ADJ, Amineddine HA, Mathias DB, Craft AW (1990) Ototoxicity of cisplatinum in children and adolescents. Br J Cancer 61:927–931. https://doi.org/10.1038/bjc.1990.208

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bertolini P, Lassalle M, Mercier G, Raquin MA, Izzi G, Corradini N, Hartmann O (2004) Platinum compound-related ototoxicity in children. J Pediatr Hematol Oncol 26:649–655. https://doi.org/10.1097/01.mph.0000141348.62532.73

Article  PubMed  Google Scholar 

Bass JK, Hua CH, Huang J, Onar-Thomas A, Ness KK, Jones S, White S, Bhagat SP, Chang KW, Merchant TE (2016) Hearing loss in patients who received cranial radiation therapy for childhood cancer. J Clin Oncol 34:1248–1255. https://doi.org/10.1200/JCO.2015.63.6738

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rutkowsi S, Dobke J HIT 2000. https://www.gpoh.de/kinderkrebsinfo/content/fachinformationen/studienportal/abgeschlossene_studien_register/hit_2000_und_hit_2000_interim/index_ger.html. Accessed 3 Sept 2024

Beier D, Proescholdt M, Reinert C, Pietsch T, Jones DTW, Pfister SM, Hattingen E, Seidel C, Dirven L, Luerding R, Reijneveld J, Warmuth-Metz M, Bonsanto M, Bremer M, Combs SE, Rieken S, Herrlinger U, Kuntze H, Mayer-Steinacker R, Moskopp D, Schneider T, Beringer A, Schlegel U, Stummer W, Welker H, Weyerbrock A, Paulsen F, Rutkowski S, Weller M, Wick W, Di Kortmann R, Bogdahn U, Hau P (2018) Multicenter pilot study of radiochemotherapy as first-line treatment for adults with medulloblastoma (NOA-07). Neuro Oncol 20:400–410. https://doi.org/10.1093/neuonc/nox155

Article  CAS  PubMed  Google Scholar 

Dobke J SIOP PNET 5 MB. https://www.gpoh.de/kinderkrebsinfo/content/fachinformationen/studienportal/onkologische_studien_und_register/siop_pnet_5_mb/index_ger.html. Accessed 3 Sept 2024

Mynarek M, Milde T, Padovani L, Janssens GO, Kwiecien R, Mosseri V, Clifford SC, Doz F, Rutkowski S (2021) SIOP PNET5 MB trial: history and concept of a molecularly stratified clinical trial of risk-adapted therapies for standard-risk medulloblastoma. Cancers. https://doi.org/10.3390/cancers13236077

Article  PubMed  PubMed Central  Google Scholar 

Schmidt CM, Bartholomäus E, Deuster D, Heinecke A, Dinnesen AG (2007) Die „Münsteraner klassifikation“. eine neue einteilung der hochtonschwerhörigkeit nach cisplatingabe. HNO 55:299–306. https://doi.org/10.1007/s00106-005-1368-1

Article  PubMed  Google Scholar 

World Health Organization (2021) World report on hearing

Google Scholar 

Monson BB, Hunter EJ, Lotto AJ, Story BH (2014) The perceptual significance of high-frequency energy in the human voice. Front Psychol 5:1–11. https://doi.org/10.3389/fpsyg.2014.00587

Article  Google Scholar 

Moore BCJ (2016) A review of the perceptual effects of hearing loss for frequencies above 3 kHz. Int J Audiol 55:707–714. https://doi.org/10.1080/14992027.2016.1204565

Article  PubMed  Google Scholar 

Levy SC, Freed DJ, Nilsson M, Moore BCJ, Puria S (2015) Extended high-frequency bandwidth improves speech reception in the presence of spatially separated masking speech. Ear Hear 36:e214–e224. https://doi.org/10.1097/AUD.0000000000000161

Article  PubMed  PubMed Central  Google Scholar