Shyam Menon et al. Stratification of Barrett’s esophagus surveillance based on p53 immunohistochemistry: a cost-effectiveness analysis by an international collaborative group

Surveillance of Barrett’s esophagus (BE) based on p53 immunohistochemistry (IHC) was compared with conventional BE surveillance in a Markov model. Surveillance based on abnormal p53 IHC appeared to be cost-effective, with an incremental cost–effectiveness ratio (ICER) of $8258, and was associated with a 14% reduction in endoscopy burden and a 59% increase in dysplasia detection. This p53-based surveillance strategy will improve the cost-effectiveness and reduce the unnecessary burden of BE surveillance, both for patients and healthcare systems.

Article published online:
27 September 2024

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