Po-Tsang Huang, School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
Yen-Ling Chen, Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi 621301, Taiwan
Yi-Hui Lin, School of Pharmacy, China Medical University, Taichung 406040, Taiwan.
Chun-Chi Wang, School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.Follow
Huan-Tsung Chang, Department of Biomedical Sciences, Chang Gung University, Taoyuan 33302, Taiwan.

Gold nanoparticles (AuNPs) have become the rising stars in the field of nanotechnology and made a revolution in exploiting the profundity of genomics due to their distinguished properties such as stability, ease in preparation and conjugation, biocompatibility, and unique optical properties. These characteristics have greatly expanded their applications such as sensitive and selective quantitation of nucleic acids and as effective carriers for specifically delivering various important molecules/biomolecules to various targets, which are the cornerstone in treating genetic disorders. This review comprehensively discusses the most recent progress in utilization of AuNPs in quantitation and delivery of nucleic acids. The future prospects and challenges of various methods have also been illustrated. It is believed that researchers will continue to overcome the limitations in previous approaches and AuNPs will still play vital roles in the development of diagnosis and treatment of gene-related diseases.

Huang, Po-Tsang; Chen, Yen-Ling; Lin, Yi-Hui; Wang, Chun-Chi; and Chang, Huan-Tsung (2024) "Functional gold nanoparticles for analysis and delivery of nucleic acids," Journal of Food and Drug Analysis: Vol. 32 : Iss. 3 , Article 2.
Available at: https://doi.org/10.38212/2224-6614.3514

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