Abdel-Tawab M, Werz O, Schubert-Zsilavecz M (2011) Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data. Clin Pharmacokinet 50:349–369

Article  PubMed  CAS  Google Scholar 

Agarwal S, Misra R, Aggarwal A (2008) Interleukin 17 levels are increased in juvenile idiopathic arthritis synovial fluid and induce synovial fibroblasts to produce proinflammatory cytokines and matrix metalloproteinases. J Rheumatol 35:515–519

PubMed  CAS  Google Scholar 

Anna Birková B, Hubková B, Bolerázska M et al (2020) Caffeic acid: a brief overview of its presence, metabolism, and bioactivity. Bioact Compd Health Dis 3(4):74–81

Google Scholar 

Ávila MF, Torrente D, Cabezas R et al (2014) Structural insights from GRP78–NF-κB binding interactions: a computational approach to understand a possible neuroprotective pathway in brain injuries. J Theor Biol 345:43–51

Article  PubMed  Google Scholar 

Bhandari SR, Kapadi AH (1983) A 9, 10-dihydrophenanthrene from tubers of Eulophia nuda. Phytochem 22:747–748

Article  CAS  Google Scholar 

Bhandari SR, Kapadi AH, Mujumder PL (1985) Nudol, a phenanthrene of the orchids Eulophia nuda, Eria carinata and Eria stricta. Phytochem 24:801–804

Article  CAS  Google Scholar 

Burrage PS, Mix KS, Brinckerhoff CE (2006) Autocrine production of IL-1 beta by human osteoarthritis-affected cartilage and differential regulation of endogenous nitric oxide, IL-6, prostaglandin E2, and IL-8. Front Biosci 11:529–543

Article  PubMed  CAS  Google Scholar 

Chen MP, Yang SH, Chou CH (2010) The chondroprotective effects of ferulic acid on hydrogen peroxide-stimulated chondrocytes: inhibition of hydrogen peroxide-induced pro-inflammatory cytokines and metalloproteinase gene expression at the mRNA level. Inflamm Res 59:587–595

Article  PubMed  CAS  Google Scholar 

Cheng B, Gao Y, Lian J et al (2017) Anti-inflammatory effects of pitavastatin in interleukin-1β-induced SW982 human synovial cells. Int Immunopharmacol 50:224–229

Article  PubMed  CAS  Google Scholar 

Dawande VR, Gurav RV (2021) Qualitative analysis of phytochemical in Eulophia nuda using LCMS. J Med Plants Stud 9:136–140

Google Scholar 

Du K, Fang X, Li Z (2021) Ferulic acid suppresses interleukin-1β-induced degeneration of chondrocytes isolated from patients with osteoarthritis through the SIRT1/AMPK/PGC-1α signaling pathway. Immun Inflamm Dis 9:710–720

Article  PubMed  PubMed Central  CAS  Google Scholar 

Duan W, Li H (2018) Combination of NF-kB targeted siRNA and methotrexate in a hybrid nanocarrier towards the effective treatment in rheumatoid arthritis. J Nanobiotechnology. 16:1–9

Article  Google Scholar 

Felson DT, ZhangY HMT et al (1997) Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham Study. Arthritis Rheumatol 40:728–733

Article  CAS  Google Scholar 

Fossiez F, Djossou O, Chomarat P et al (1996) T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med 183:2593–2603

Article  PubMed  CAS  Google Scholar 

Gheibi S, Shokohinia Y, Kiani A, Sadrjavadi, (2016) Molecular insight into the Grandivitin-matrix metalloproteinase 9 interactions. J Photochem Photobiol B: Biol 162: 493–499.Gilmore TD (2006) Introduction to NF-κB: players, pathways, perspectives. Oncogene 25:6680–6684

Google Scholar 

Goldring MB, Goldring SR (2010) Introduction to NF-κB: players, pathways, perspectives. Ann N Y Acad Sci 1192:230–237

Article  PubMed  CAS  Google Scholar 

Goldring MB, Otero M (2011) Inflammation in osteoarthritis. Curr Opin Rheumatol 23:1–13

Article  Google Scholar 

Hada S, Yadav DK, Roat P et al (2020) Eulophia nuda: a review of its traditional uses, phytochemistry and pharmacology. Pharm Chem J 54:40–45

Article  CAS  Google Scholar 

Hamasaki M, Terkawi MA, Onodera T et al (2021) A novel cartilage fragments stimulation model revealed that macrophage inflammatory response causes an upregulation of catabolic factors of chondrocytes in vitro. Cartilage 12:354–361

Article  PubMed  CAS  Google Scholar 

Han Z, Boyle DL, Manning AM et al (1998) AP-1 and NF-kB regulation in rheumatoid arthritis and murine collagen-induced arthritis. Autoimmunity 28:197–208

Article  PubMed  CAS  Google Scholar 

Hasan S, Bonde BK, Buchan NS et al (2012) Network analysis has diverse roles in drug discovery. Drug Discov Today 17:869–874

Article  PubMed  Google Scholar 

Hassan N, Ali A, Withycombe C et al (2018) TET-2 up-regulation is associated with the anti-inflammatory action of Vicenin-2. Cytokine 108:37–42

Article  PubMed  CAS  Google Scholar 

Hawker GA (2019) Osteoarthritis is a serious disease. Clin Exp Rheumatol 37:3–6

PubMed  Google Scholar 

Jaglan P, Buttar HS, Al-bawareed OA et al (2022) Potential health benefits of selected fruits: apples, blueberries, grapes, guavas, mangos, pomegranates, and tomatoes. In: Singh RB, Watanabe S, Isaza AA (eds) Functional foods and nutraceuticals in metabolic and non-communicable diseases, 1st edn. Academic press, San Diego, CA, USA, pp 359–370

Chapter  Google Scholar 

Kanekar Y, Basha K, Duche S et al (2013) Regioselective synthesis of phenanthrenes and evaluation of their anti-oxidant based anti-inflammatory potential. Eur J Med Chem 67:454–463

Article  PubMed  CAS  Google Scholar 

Katari SK, Natarajan P, Swargam S, Kanipakam H (2016) Inhibitor design against JNK1 through e-pharmacophore modeling docking and molecular dynamics simulations. J Recept Signal Transduct 36(6):558–571

Article  CAS  Google Scholar 

Katz Y, Nadiv O, Beer Y (2001) Interleukin-17 enhances tumor necrosis factor alpha-induced synthesis of interleukins 1, 6, and 8 in skin and synovial fibroblasts: a possible role as a “fine-tuning cytokine” in inflammation processes. Arthritis Rheumatol 44:2176–2184

Article  CAS  Google Scholar 

Kitanaka T, Nakano R, Kitanaka N (2017) JNK activation is essential for activation of MEK/ERK signaling in IL-1β-induced COX-2 expression in synovial fibroblasts. Sci Rep 7:1–14

Article  Google Scholar 

Kong JM, Goh NK, Chia LS et al (2003) Recent advances in traditional plant drugs and orchids. Acta Pharmacol Sin 24:7–21

PubMed  CAS  Google Scholar 

Kong H, Wang XQ, Zhang XA (2022) Exercise for osteoarthritis: a literature review of pathology and mechanism. Front Aging Neurosci 14:854026

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kotake S, Udagawa N, Takahashi N et al (1999) IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 103:1345–1352

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu SC, Tsai CH, Wang YH (2022) Melatonin abolished proinflammatory factor expression and antagonized osteoarthritis progression in vivo. Cell Death Dis 13:1–10

Google Scholar 

Liu Y, Peng H, Meng Z et al (2015) Correlation of IL-17 level in synovia and severity of knee osteoarthritis. Med Sci Monit 21:1732–1736

Article  PubMed  PubMed Central  Google Scholar 

Mali PY, Bhadane VV (2008) Some rare plants of ethnomedicinal properties from Jalgaon district of Maharashtra. Int J Green Pharm 2:76–78

Article  Google Scholar 

Mansell JP, Tarlton JF, Bailey AJ (1997) Biochemical evidence for altered subchondral bone collagen metabolism in osteoarthritis of the hip. Br J Rheumatol 36:16–19

Article  PubMed  CAS  Google Scholar 

McAlindon TE, Bannuru R, Sullivan MC et al (2014) OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthr Cartil 22:363–388

Article  CAS  Google Scholar