Guan L-Z, Tong Q, Xu J. Elevated serum levels of mannose-binding lectin and diabetic nephropathy in type 2 diabetes. PLoS ONE. 2015;10(3):e0119699.

Article  PubMed  PubMed Central  Google Scholar 

Yang W, Lu J, Weng J, Jia W, Ji L, Xiao J, et al. Prevalence of diabetes among men and women in China. N Engl J Med. 2010;362(12):1090–101.

Article  CAS  PubMed  Google Scholar 

Kaunisto MA, Sjölind L, Sallinen R, Pettersson-Fernholm K, Saraheimo M, Fröjdö S, et al. Elevated MBL concentrations are not an indication of association between the MBL2 gene and type 1 diabetes or diabetic nephropathy. Diabetes. 2009;58(7):1710–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao Y, Lin W, Li Z, Lin J, Wang S, Zeng C, et al. High expression of mannose-binding lectin and the risk of vascular complications of diabetes: evidence from a meta-analysis. Diabetes Technol Ther. 2015;17(7):490–7.

Article  CAS  PubMed  Google Scholar 

Flyvbjerg A. Diabetic Angiopathy, the complement system and the tumor necrosis factor superfamily. Nat Reviews Endocrinol. 2010;6(2):94–101.

Article  CAS  Google Scholar 

Kobrin Klein BE. Overview of epidemiologic studies of diabetic retinopathy. Ophthalmic Epidemiol. 2007;14(4):179–83.

Article  Google Scholar 

Liu Z, Fu C, Wang W, Xu B. Prevalence of chronic complications of type 2 diabetes mellitus in outpatients-a cross-sectional hospital based survey in urban China. Health Qual Life Outcomes. 2010;8(1):1–9.

Article  Google Scholar 

Yau JW, Rogers SL, Kawasaki R, Lamoureux EL, Kowalski JW, Bek T, et al. Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care. 2012;35(3):556–64.

Article  PubMed  PubMed Central  Google Scholar 

Forbes JM, Cooper ME. Mechanisms of diabetic complications. Physiol Rev. 2013;93(1):137–88.

Article  CAS  PubMed  Google Scholar 

Lenoir O, Jasiek M, Hénique C, Guyonnet L, Hartleben B, Bork T, et al. Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis. Autophagy. 2015;11(7):1130–45.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heiran A, Azarchehry SP, Dehghankhalili S, Afarid M, Shaabani S, Mirahmadizadeh A. Prevalence of diabetic retinopathy in the Eastern Mediterranean Region: a systematic review and meta-analysis. J Int Med Res. 2022;50(10):03000605221117134.

Article  PubMed  PubMed Central  Google Scholar 

Bodhini D, Mohan V. Diabetes burden in the IDF-MENA region. Medknow; 2022. pp. S1–2.

Teo ZL, Tham Y-C, Yu M, Chee ML, Rim TH, Cheung N, et al. Global prevalence of diabetic retinopathy and projection of burden through 2045: systematic review and meta-analysis. Ophthalmology. 2021;128(11):1580–91.

Article  PubMed  Google Scholar 

Wang N, Zhu F, Chen L, Chen K. Proteomics, metabolomics and metagenomics for type 2 diabetes and its complications. Life Sci. 2018;212:194–202.

Article  CAS  PubMed  Google Scholar 

OLFATIFAR M, KARAMI M, SHOKRI P, HOSSEINI SM. Prevalence of chronic complications and related risk factors of diabetes in patients referred to the diabetes center of Hamedan Province. 2017.

Girard D, Vandiedonck C. How dysregulation of the immune system promotes diabetes mellitus and cardiovascular risk complications. Front Cardiovasc Med. 2022;9:991716.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nedosugova LV, Markina YV, Bochkareva LA, Kuzina IA, Petunina NA, Yudina IY, et al. Inflammatory mechanisms of diabetes and its vascular complications. Biomedicines. 2022;10(5):1168.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cerar T, Barlovič DP, Zorin A, Gregorič N, Kotnik V. Activation of complement system by mannan pathway and Mbl2 genotypes in patients with type 2 diabetes and nephropathy. Slovenian Med J. 2014;83(10).

Dørflinger G, Høyem P, Laugesen E, Østergaard J, Funck K, Steffensen R, et al. High MBL-expressing genotypes are associated with deterioration in renal function in type 2 diabetes. Front Immunol. 2022;13:1080388.

Article  PubMed  PubMed Central  Google Scholar 

Holt C, Hoffmann-Petersen I, Hansen T, Parving H, Thiel S, Hovind P, et al. Association between severe diabetic retinopathy and lectin pathway proteins–an 18-year follow-up study with newly diagnosed type 1 diabetes patients. Immunobiology. 2020;225(3):151939.

Article  CAS  PubMed  Google Scholar 

Moin ASM, Nandakumar M, Diboun I, Al-Qaissi A, Sathyapalan T, Atkin SL, et al. Hypoglycemia-induced changes in complement pathways in type 2 diabetes. Atherosclerosis Plus. 2021;46:35–45.

Article  PubMed  PubMed Central  Google Scholar 

Shim K, Begum R, Yang C, Wang H. Complement activation in obesity, insulin resistance, and type 2 diabetes mellitus. World J Diabetes. 2020;11(1):1.

Article  PubMed  PubMed Central  Google Scholar 

Chang W-C, White MR, Moyo P, McClear S, Thiel S, Hartshorn KL, et al. Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza a virus infection. BMC Immunol. 2010;11(1):1–12.

Article  Google Scholar 

Bay JT, Sørensen SS, Hansen JM, Madsen HO, Garred P. Low mannose-binding lectin serum levels are associated with reduced kidney graft survival. Kidney Int. 2013;83(2):264–71.

Article  CAS  PubMed  Google Scholar 

Eisen DP, Minchinton RM. Impact of mannose-binding lectin on susceptibility to infectious diseases. Clin Infect Dis. 2003;37(11):1496–505.

Article  CAS  PubMed  Google Scholar 

Katakam L, Suresh GK. Identifying a quality improvement project. J Perinatol. 2017;37(10):1161–5.

Article  PubMed  Google Scholar 

Ezekowitz RAB. Genetic heterogeneity of mannose-binding proteins: the Jekyll and Hyde of innate immunity? Am J Hum Genet. 1998;62(1):6–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Z-Y, Sun Z-R, Zhang L-M. The relationship between serum mannose-binding lectin levels and acute ischemic stroke risk. Neurochem Res. 2014;39:248–53.

Article  CAS  PubMed  Google Scholar 

Zhang N-n, Ma A, Cheng P, Zhuang M, Cao F, Chen X, et al. Association between mannose-binding-lectin gene and type 2 diabetic patients in Chinese population living in the northern areas of China. Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua. Liuxingbingxue Zazhi. 2011;32(9):930–5.

CAS  Google Scholar 

Huang Q, Shang G, Deng H, Liu J, Mei Y, Xu Y. High mannose-binding lectin serum levels are associated with diabetic retinopathy in Chinese patients with type 2 diabetes. PLoS ONE. 2015;10(7):e0130665.

Article  PubMed  PubMed Central  Google Scholar 

Siezenga MA, Chandie Shaw PK, Daha MR, Rabelink TJ, Berger SP. Low Mannose-Binding Lectin (MBL) genotype is associated with future cardiovascular events in type 2 diabetic South asians. A prospective cohort study. Cardiovasc Diabetol. 2011;10:1–7.

Article  Google Scholar 

Hansen TK, Thiel S, Wouters PJ, Christiansen JS, Van den Berghe G. Intensive insulin therapy exerts antiinflammatory effects in critically ill patients and counteracts the adverse effect of low mannose-binding lectin levels. J Clin Endocrinol Metabolism. 2003;88(3):1082–8.

Article  CAS  Google Scholar 

Gedebjerg A, Bjerre M, Kjaergaard AD, Steffensen R, Nielsen JS, Rungby J, et al. Mannose-binding lectin and risk of cardiovascular events and mortality in type 2 diabetes: a Danish cohort study. Diabetes Care. 2020;43(9):2190–8.

Article  CAS  PubMed  Google Scholar 

Hansen T, Forsblom C, Saraheimo M, Thorn L, Wadén J, Høyem P, et al. Association between mannose-binding lectin, high-sensitivity C-reactive protein and the progression of diabetic nephropathy in type 1 diabetes. Diabetologia. 2010;53:1517–24.

Article  CAS  PubMed