Madison A. Honer1,2,3,4, Benjamin I. Ferman1,2,3,4, Zach H. Gray1,2,3,4, Elena A. Bondarenko1,2,3 and Johnathan R. Whetstine1,2,3 1Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA; 2Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA; 3Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA; 4Biomedical Sciences Program, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania 19140, USA Corresponding author: johnathan.whetstinefccc.edu Abstract

The discovery of epigenetic modulators (writers, erasers, readers, and remodelers) has shed light on previously underappreciated biological mechanisms that promote diseases. With these insights, novel biomarkers and innovative combination therapies can be used to address challenging and difficult to treat disease states. This review highlights key mechanisms that epigenetic writers, erasers, readers, and remodelers control, as well as their connection with disease states and recent advances in associated epigenetic therapies.