Sung H, Ferlay J, Siegel RL et al (2021) Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249. https://doi.org/10.3322/caac.21660

Article  CAS  PubMed  Google Scholar 

Cohen N, Fedewa S, Chen AY (2018) Epidemiology and demographics of the head and neck cancer population. Oral Maxillofac Surg Clin North Am 30(4):381–395. https://doi.org/10.1016/j.coms.2018.06.001

Article  PubMed  Google Scholar 

Alves LDB, Menezes ACS, Pereira DL, Santos MTC, Antunes HS (2021) Benefits of intraoral stents in patients with head and neck cancer undergoing radiotherapy: systematic review. Head Neck 43(5):1652–1663. https://doi.org/10.1002/hed.26620

Article  PubMed  Google Scholar 

Carvalho CG, Medeiros-Filho JB, Ferreira MC (2018) Guide for health professionals addressing oral care for individuals in oncological treatment based on scientific evidence. Support Care Cancer 26(8):2651–2661. https://doi.org/10.1007/s00520-018-4111-7. (Epub 2018 Feb 22 PMID: 29470703)

Article  PubMed  Google Scholar 

Daugėlaitė G, Užkuraitytė K, Jagelavičienė E, Filipauskas A (2019) Prevention and treatment of chemotherapy and radiotherapy induced oral mucositis. Med 55(2):1–14. https://doi.org/10.3390/medicina55020025

Article  Google Scholar 

Sroussi HY, Epstein JB, Bensadoun RJ, Saunders DP, Lalla RV, Migliorati CA, Heaivilin N, Zumsteg ZS (2017) Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis. Cancer Med. 6:2918–2931. https://doi.org/10.1002/cam4.1221

Article  PubMed  PubMed Central  Google Scholar 

Maria OM, Eliopoulos N, Muanza T (2017) Radiation-induced oral mucositis. Front. Oncol 22(7):89. https://doi.org/10.3389/fonc.2017.00089.PMID:28589080;PMCID:PMC5439125

Article  Google Scholar 

Elad S, Cheng KKF, Lalla RV et al (2020) MASCC/ISOO clinical practice guidelines for managing mucositis secondary to cancer therapy. Cancer 126(19):4423–4431. https://doi.org/10.1002/cncr.33100

Article  PubMed  Google Scholar 

Kuhn-Dall’Magro A, Zamboni E, Fontana T et al (2022) Low-level laser therapy in the management of oral mucositis induced by radiotherapy a randomized double-blind clinical trial. J Contemp Dent Pract. 23:31–36. https://doi.org/10.5005/jp-journals-10024-3277

Article  PubMed  Google Scholar 

Blakaj A, Bonomi M, Gamez ME, Blakaj DM (2019) Oral mucositis in head and neck cancer: evidence-based management and review of clinical trial data. Oral Oncol 95(June):29–34. https://doi.org/10.1016/j.oraloncology.2019.05.013

Article  PubMed  Google Scholar 

Dompe C, Moncrieff L, Matys J, Grzech-Leśniak K, Kocherova I, Bryja A, Bruska M, Dominiak M, Mozdziak P, Skiba THI, Shibli JA, Angelova Volponi A, Kempisty B, Dyszkiewicz-Konwińska M (2020) Photobiomodulation-underlying mecha and clinical applications. J Clin Med 9(6):1724. https://doi.org/10.3390/jcm9061724.PMID:32503238;PMCID:PMC7356229

Article  PubMed  PubMed Central  Google Scholar 

Maver-Biscanin M, Mravak-Stipetic M, Jerolimov V, Biscanin A (2004) Fungicidal effect of diode laser irradiation in patients with denture stomatitis. Lasers Surg Med 35(4):259–262. https://doi.org/10.1002/lsm.20075. (PMID: 15493034)

Article  PubMed  Google Scholar 

Roomaney IA, Holmes HK, Engel MM (2021) Treatment of oral fungal infections using photodynamic therapy: systematic review and meta-analysis. Clin Exp Dent Res. 7:354–364. https://doi.org/10.1002/cre2.408

Article  PubMed  PubMed Central  Google Scholar 

Ziental D, Mlynarczyk DT, Czarczynska-Goslinska B, Lewandowski K, Sobotta L (2021) Photosensitizers mediated photodynamic inactivation against fungi. Nanomaterials (Basel) 11(11):2883. https://doi.org/10.3390/nano11112883

Article  CAS  PubMed  Google Scholar 

de DantasJB L, Martins GB, Lima HR, Carrera M, de ReisSR A, Medrado ARAP (2020) Evaluation of preventive laser photobiomodulation in patients with head and neck cancer undergoing radiochemotherapy: laser in patients with head and neck cancer. Spec Care Dentist. 40:364–373. https://doi.org/10.1111/scd.12486

Article  Google Scholar 

Nishii M, Soutome S, Kawakita A et al (2020) Factors associated with severe oral mucositis and candidiasis in patients undergoing radiotherapy for oral and oropharyngeal carcinomas: a retrospective multicenter study of 326 patients. Support Care Cancer 28:1069–1075. https://doi.org/10.1007/s00520-019-04885-z

Article  PubMed  Google Scholar 

Davy C, Heathcote S (2021) A systematic review of interventions to mitigate radiotherapy-induced oral mucositis in head and neck cancer patients. Support Care Cancer 29(4):2187–2202. https://doi.org/10.1007/s00520-020-05548-0

Article  PubMed  Google Scholar 

Pereira IF, Firmino RT, Meira HC, Vasconcelos BCDE, Noronha VRADS, Santos VR. Radiation-induced oral mucositis in Brazilian patients: prevalence and associated factors. In Vivo (Brooklyn). 2019;33:605–609. https://doi.org/10.21873/invivo.11517

Meurman JH, Grönroos L (2010) Oral and dental health care of oral cancer patients: hyposalivation, caries and infections. Oral Oncol 46(6):464–467. https://doi.org/10.1016/j.oraloncology.2010.02.025

Article  PubMed  Google Scholar 

Chitapanarux I, Wongsrita S, Sripan P et al (2021) An underestimated pitfall of oral candidiasis in head and neck cancer patients undergoing radiotherapy: an observation study. BMC Oral Health 21(1):1–10. https://doi.org/10.1186/s12903-021-01721-x

Article  CAS  Google Scholar 

Gaetti Jardim Junior, E., Cunha-Correia, A. de S., Okamoto, A. C., & Gaetti-Jardim, E. C. (2017). Oral microbiota and mucositis in patients with head and neck cancer undergoing radiotherapy: literature review. ARCHIVES OF HEALTH INVESTIGATION, 6(2). https://doi.org/10.21270/archi.v6i2.1797

Genot MT, Klastersky J (2005) Low-level laser for prevention and therapy of oral mucositis induced by chemotherapy or radiotherapy. Curr Opin Oncol 17(3):236–240. https://doi.org/10.1097/01.cco.0000156196.22249.76

Article  PubMed  Google Scholar 

Sunaga T, Nagatani A, Fujii N, Hashimoto T, Watanabe T, Sasaki T (2021) The association between cumulative radiation dose and the incidence of severe oral mucositis in head and neck cancers during radiotherapy. Cancer Rep 4(2):1–6. https://doi.org/10.1002/cnr2.1317

Article  CAS  Google Scholar 

Bamps M, Dok R, Nuyts S (2018) Low-level laser therapy stimulates proliferation in head and neck squamous cell carcinoma cells. Front Oncol. 8:1–6. https://doi.org/10.3389/fonc.2018.00343

Article  Google Scholar 

Courtois E, Bouleftour W, Guy JB et al (2021) Mechanisms of PhotoBioModulation (PBM) focused on oral mucositis prevention and treatment: a scoping review. BMC Oral Health 21(1):1–11. https://doi.org/10.1186/s12903-021-01574-4

Article  Google Scholar 

Karu T (1989) Photobiology of low-power laser effects. Health Phys 56(5):691–704. https://doi.org/10.1097/00004032-198905000-00015

Article  CAS  PubMed  Google Scholar 

Carvalho PAG, Jaguar GC, Pellizzon AC, Prado JD, Lopes RN, Alves FA (2011) Evaluation of low-level laser therapy in the prevention and treatment of radiation-induced mucositis: a double-blind randomized study in head and neck cancer patients. Oral Oncol 47(12):1176–1181. https://doi.org/10.1016/j.oraloncology.2011.08.021

Article  CAS  PubMed  Google Scholar 

Oton-Leite AF, Elias LSA, Morais MO et al (2013) Effect of low level laser therapy in the reduction of oral complications in patients with cancer of the head and neck submitted to radiotherapy. Spec Care Dent 33(6):294–300. https://doi.org/10.1111/j.1754-4505.2012.00303.x

Article  Google Scholar 

Oton-Leite AF, Silva GBL, Morais MO et al (2015) Effect of low-level laser therapy on chemoradiotherapy-induced oral mucositis and salivary inflammatory mediators in head and neck cancer patients. Lasers Surg Med 47(4):296–305. https://doi.org/10.1002/lsm.22349

Article  PubMed  Google Scholar 

Martins AFL, Morais MO, de Sousa-Neto SS et al (2021) Photobiomodulation reduces the impact of radiotherapy on oral health-related quality of life due to mucositis-related symptoms in head and neck cancer patients. Lasers Med Sci 36(4):903–912. https://doi.org/10.1007/s10103-020-03167-z

Article  PubMed  Google Scholar 

Simões A, Eduardo FP, Luiz AC et al (2009) Laser phototherapy as topical prophylaxis against head and neck cancer radiotherapy-induced oral mucositis: comparison between low and high/low power lasers. Lasers Surg Med 41(4):264–270. https://doi.org/10.1002/lsm.20758

Article  PubMed  Google Scholar 

Cronshaw M, Parker S, Anagnostaki E, Mylona V, Lynch E, Grootveld M (2020) Photobiomodulation and oral mucositis: a systematic review. Dent J 8(3):1–19. https://doi.org/10.3390/DJ8030087

Article