Vaginal Malignant Melanoma-Case Report and Comprehensive Review of Literature

Goldemberg DC, Thuler LCS, de Melo AC. An update on mucosal melanoma: future directions. Acta Dermatovenerol Croat ADC. 2019;27(1):11–5.

CAS  PubMed  Google Scholar 

Nigogosyan G, De Pava SL, Pickren JW. Melanoblasts in vaginal mucosa. Orig Prim Malig Melanoma Cancer. 1964;17(7):912–3.

CAS  Google Scholar 

Mikkelsen LH. Molecular biology in conjunctival melanoma and the relationship to mucosal melanoma. Acta Ophthalmol (Copenh). 2020;98(Suppl 115):1–27.

Article  Google Scholar 

Pandey M, Mathew A, Abraham EK, Ahamed IM, Nair KM. Primary malignant melanoma of the mucous membranes. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol. 1998;24(4):303–7.

CAS  Google Scholar 

Rema P, Suchetha S, Ahmed I. Primary malignant melanoma of vagina treated by total pelvic xenteration. Indian J Surg. 2016;78(1):65.

Article  CAS  PubMed  Google Scholar 

Kant RH, Iqbal S, Ahmad MM, Shafi J, Rashid S, Sharma P. A rare case of malignant melanoma of vagina. J Obstet Gynaecol India. 2018;68(4):323–5.

Article  PubMed  Google Scholar 

Chitrathara K, Subramanian A, Raj S, Sanam P, Kunheri B. Primary vaginal malignant melanoma with urethral involvement managed by bladder preservation. Indian J Gynecol Oncol. 2017;15(1):3.

Article  Google Scholar 

Frumovitz M, Etchepareborda M, Sun CC, Soliman PT, Eifel PJ, Levenback CF, et al. Primary malignant melanoma of the vagina. Obstet Gynecol. 2010;116(6):1358–65.

Article  PubMed  Google Scholar 

Pandey G, Dave P, Patel S, Patel B, Arora R, Parekh C, et al. Female genital tract melanoma: analysis from a regional cancer institute. Turk J Obstet Gynecol. 2020;17(1):46–51.

Article  PubMed  PubMed Central  Google Scholar 

Gökaslan H, Şişmanoğlu A, Pekin T, Kaya H, Ceyhan N. Primary malignant melanoma of the vagina: a case report and review of the current treatment options. Eur J Obstet Gynecol Reprod Biol. 2005;121(2):243–8.

Article  PubMed  Google Scholar 

Chaudhuri S, Das D, Chowdhury S, Gupta AD. Primary malignant melanoma of the vagina: a case report and review of literature. South Asian J Cancer. 2013;2(1):4.

Article  PubMed  PubMed Central  Google Scholar 

Androutsopoulos G, Terzakis E, Ioannidou G, Tsamandas A, Decavalas G. Vaginal primary malignant melanoma: a rare and aggressive tumor. Case Rep Obstet Gynecol. 2013;2013: 137908.

PubMed  PubMed Central  Google Scholar 

Oguri H, Izumiya C, Maeda N, Fukaya T, Moriki T. A primary amelanotic melanoma of the vagina, diagnosed by immunohistochemical staining with HMB-45, which recurred as a pigmented melanoma. J Clin Pathol. 2004;57(9):986–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takehara K, Nakamura H, Mizunoe T, Nogawa T. Primary malignant melanoma of the vagina with a survival of longer than 5 years after recurrence: case report and review of the literature. Gynecol Obstet. 2013;1:3.

Google Scholar 

Si L, Kong Y, Xu X, Flaherty KT, Sheng X, Cui C, et al. Prevalence of BRAF V600E mutation in Chinese melanoma patients: large scale analysis of BRAF and NRAS mutations in a 432-case cohort. Eur J Cancer Oxf Engl. 2012;48(1):94–100.

Article  CAS  Google Scholar 

Wang H, Wu X, Zhang X, Yang X, Long Y, Feng Y, et al. Prevalence of NRAS mutation, PD-L1 expression and amplification, and overall survival analysis in 36 primary vaginal melanomas. Oncologist. 2020;25(2):e291-301.

Article  CAS  PubMed  Google Scholar 

Parikh JH, Barton DPJ, Ind TEJ, Sohaib SA. MR imaging features of vaginal malignancies. Radiogr Rev Publ Radiol Soc. 2008;28(1):49–63.

Google Scholar 

Hacker NF, Eifel PJ, van der Velden J. Cancer of the vagina. Int J Gynecol Obstet. 2015;131(S2):S84–7.

Google Scholar 

Kalampokas E, Kalampokas T, Damaskos C. Primary vaginal melanoma, a rare and aggressive entity a case report and review of the literature. Vivo. 2017;31(1):133–40.

Article  Google Scholar 

Jamaer E, Liang Z, Stagg B. Primary malignant melanoma of the vagina. BMJ Case Rep CP. 2020;13(1): e232200.

Article  Google Scholar 

Garbe C, Peris K, Hauschild A, Saiag P, Middleton M, Spatz A, et al. Diagnosis and treatment of melanoma european consensus-based interdisciplinary guideline update. Eur J Cancer Oxf Engl. 2012;48(15):2375–90.

Article  Google Scholar 

Hieken TJ, Kreidieh F, Aedo-Lopez V, Block MS, McArthur GA, Amaria RN. Neoadjuvant immunotherapy in melanoma: the paradigm shift. Am Soc Clin Oncol Educ Book. 2023;43: e390614.

Article  PubMed  Google Scholar 

Rozeman EA, Menzies AM, van Akkooi ACJ, Adhikari C, Bierman C, van de Wiel BA, et al. Identification of the optimal combination dosing schedule of neoadjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma (OpACIN-neo): a multicentre, phase 2, randomised, controlled trial. Lancet Oncol. 2019;20(7):948–60.

Article  CAS  PubMed  Google Scholar 

Amaria RN, Postow M, Burton EM, Tetzlaff MT, Ross MI, Torres-Cabala C, et al. Neoadjuvant relatlimab and nivolumab in resectable melanoma. Nature. 2022;611(7934):155–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patel SP, Othus M, Chen Y, Wright GP, Yost KJ, Hyngstrom JR, et al. Neoadjuvant-adjuvant or adjuvant-only pembrolizumab in advanced melanoma. N Engl J Med. 2023;388(9):813–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schiavone MB, Broach V, Shoushtari AN, Carvajal RD, Alektiar K, Kollmeier MA, et al. Combined immunotherapy and radiation for treatment of mucosal melanomas of the lower genital tract. Gynecol Oncol Rep. 2016;16:42–6.

Article  PubMed  PubMed Central  Google Scholar 

Kirschner AN, Kidd EA, Dewees T, Perkins SM. Treatment approach and outcomes of vaginal melanoma. Int J Gynecol Cancer. 2013;23(8):1484–9.

Article  PubMed  Google Scholar 

Abramova L, Parekh J, Irvin WP, Rice LW, Taylor PT, Anderson WA, et al. Sentinel node biopsy in vulvar and vaginal melanoma: presentation of six cases and a literature review. Ann Surg Oncol. 2002;9(9):840–6.

Article  PubMed  Google Scholar 

Kirkwood JM, Strawderman MH, Ernstoff MS, Smith TJ, Borden EC, Blum RH. Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the eastern cooperative oncology group trial EST 1684. J Clin Oncol. 1996;14(1):7–17.

Article  CAS  PubMed  Google Scholar 

Tasaka R, Fukuda T, Wada T, Kawanishi M, Imai K, Kasai M, et al. A retrospective clinical analysis of 5 cases of vaginal melanoma. Mol Clin Oncol. 2017;6(3):373–6.

Article  PubMed  PubMed Central  Google Scholar 

Petru E, Nagele F, Czerwenka K, Graf AH, Lax S, Bauer M, et al. Primary malignant melanoma of the vagina: long-term remission following radiation therapy. Gynecol Oncol. 1998;70(1):23–6.

Article  CAS  PubMed  Google Scholar 

Irvin WP, Bliss SA, Rice LW, Taylor PT, Andersen WA. Malignant melanoma of the vagina and locoregional control: radical surgery revisited. Gynecol Oncol. 1998;71(3):476–80.

Article  PubMed  Google Scholar 

Rebegea L, Firescu D, Stoleriu G, Arbune M, Anghel R, Dumitru M, et al. Radiotherapy and immunotherapy, combined treatment for unresectable mucosal melanoma with vaginal origin. Appl Sci. 2022;12(15):7734.

Article  CAS  Google Scholar 

Schonewolf CA, Jaworski EM, Allen SG, McLean K, Lao CD, Schuchter LM, et al. Complete response after stereotactic body radiation therapy with concurrent immunotherapy for vaginal melanoma. Adv Radiat Oncol. 2021;7(2): 100839.

Article  PubMed  PubMed Central  Google Scholar 

Lian B, Si L, Cui C, Chi Z, Sheng X, Mao L, et al. Phase II randomized trial comparing high-dose IFN-α2b with temozolomide plus cisplatin as systemic adjuvant therapy for resected mucosal melanoma. Clin Cancer Res Off J Am Assoc Cancer Res. 2013;19(16):4488–98.

Article  CAS  Google Scholar 

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