A multi-environmental source approach to explore associations between metals exposure and olfactory identification among school-age children residing in northern Italy

Hoffman HJ, Ishii EK, MacTurk RH. Age-related changes in the prevalence of smell/taste problems among the United States adult population. Results of the 1994 disability supplement to the National Health Interview Survey (NHIS). Ann N Y Acad Sci. 1998;855:716–22.

Article  CAS  PubMed  Google Scholar 

Murphy C, Schubert CR, Cruickshanks KJ, Klein BE, Klein R, Nondahl DM. Prevalence of olfactory impairment in older adults. JAMA. 2002;288:2307–12.

Article  PubMed  Google Scholar 

Lafreniere D, Mann N. Anosmia: loss of smell in the elderly. Otolaryngol Clin North Am. 2009;42:123–31.

Article  PubMed  Google Scholar 

Hoffman HJ, Rawal S, Li CM, Duffy VB. New chemosensory component in the U.S. National Health and Nutrition Examination Survey (NHANES): first-year results for measured olfactory dysfunction. Rev Endocr Metab Disord. 2016;17:221–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Santos DV, Reiter ER, DiNardo LJ, Costanzo RM. Hazardous events associated with impaired olfactory function. Arch Otolaryngol Head Neck Surg. 2004;130:317–9.

Article  PubMed  Google Scholar 

Boesveldt S, Parma V. The importance of the olfactory system in human well-being, through nutrition and social behavior. Cell Tissue Res. 2021;383:559–67.

Article  PubMed  PubMed Central  Google Scholar 

Croy I, Nordin S, Hummel T. Olfactory disorders and quality of life – an updated review. Chem Senses. 2014;39:185–94.

Article  PubMed  Google Scholar 

Croy I, Negoias S, Novakova L, Landis BN, Hummel T. Learning about the functions of the olfactory system from people without a sense of smell. PLoS ONE. 2012;7:e33365.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bojanowski V, Hummel T, Croy I. [Isolated congenital anosmia-clinical and daily life aspects of a life without a sense of smell]. Laryngorhinootologie. 2013;92:30–3.

CAS  PubMed  Google Scholar 

Croy I, Hummel T. Olfaction as a marker for depression. J Neurol. 2017;264:631–8.

Article  CAS  PubMed  Google Scholar 

Ferdenzi C, Schaal B, Roberts SC. Family scents: developmental changes in the perception of kin body odor? J Chem Ecol. 2010;36:847–54.

Article  CAS  PubMed  Google Scholar 

Attems J, Walker L, Jellinger KA. Olfactory bulb involvement in neurodegenerative diseases. Acta Neuropathol. 2014;127:459–75.

Article  CAS  PubMed  Google Scholar 

Devanand DP. Olfactory identification deficits, cognitive decline, and dementia in older adults. Am J Geriatr Psychiatry. 2016;24:1151–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Doty RL. Olfactory dysfunction in neurodegenerative diseases: is there a common pathological substrate? Lancet Neurol. 2017;16:478–88.

Article  PubMed  Google Scholar 

Marin C, Vilas D, Langdon C, Alobid I, López-Chacón M, Haehner A, et al. Olfactory dysfunction in neurodegenerative diseases. Curr Allergy Asthma Rep. 2018;18:42.

Article  PubMed  Google Scholar 

Jung HJ, Shin IS, Lee JE. Olfactory function in mild cognitive impairment and Alzheimer’s disease: a meta-analysis. Laryngoscope. 2019;129:362–9.

Article  PubMed  Google Scholar 

Doty RL, Hawkes CH. Chemosensory dysfunction in neurodegenerative diseases. Handb Clin Neurol. 2019;164:325–60.

Article  PubMed  Google Scholar 

Waldmann S, Lübke KT, Pentzek M, Pause BM. [Olfactory dysfunctions: references to neuropsychiatric disorders and diagnostics]. Fortschr Neurol Psychiatr. 2020;88:184–93.

PubMed  Google Scholar 

Godoy MD, Voegels RL, Pinna FeR, Imamura R, Farfel JM. Olfaction in neurologic and neurodegenerative diseases: a literature review. Int Arch Otorhinolaryngol. 2015;19:176–9.

PubMed  Google Scholar 

Schriever VA, Gellrich J, von der Hagen M, Hummel T. Acquired olfactory dysfunction in children and adolescents: a systematic review of the literature. Chem Senses. 2018;43:571–81.

Article  PubMed  Google Scholar 

Guarneros M, Ortiz-Romo N, Alcaraz-Zubeldia M, Drucker-Colín R, Hudson R. Nonoccupational environmental exposure to manganese is linked to deficits in peripheral and central olfactory function. Chem Senses. 2013;38:783–91.

Article  CAS  PubMed  Google Scholar 

Casjens S, Pesch B, van Thriel C, Zschiesche W, Behrens T, Weiss T, et al. Associations between blood lead, olfaction and fine-motor skills in elderly men: results from the Heinz Nixdorf Recall Study. Neurotoxicology. 2018;68:66–72.

Article  CAS  PubMed  Google Scholar 

Genter MB, Doty RL. Toxic exposures and the senses of taste and smell. Handb Clin Neurol. 2019;164:389–408.

Article  PubMed  Google Scholar 

Mori I. The olfactory bulb: a link between environmental agents and narcolepsy, from the standpoint of autoimmune etiology. Med Hypotheses. 2019;131:109294.

Article  PubMed  Google Scholar 

Ajmani GS, Suh HH, Pinto JM. Effects of ambient air pollution exposure on olfaction: a review. Environ Health Perspect. 2016;124:1683–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grashow R, Sparrow D, Hu H, Weisskopf MG. Cumulative lead exposure is associated with reduced olfactory recognition performance in elderly men: the Normative Aging Study. Neurotoxicology. 2015;49:158–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Caruso A, Lucchini R, Toffoletto F, Porro S, Moroni P, Mascagni P. [Study of the olfactory function of a group of workers with significant lead exposure]. G Ital Med Lav Ergon. 2007;29:460–3.

CAS  PubMed  Google Scholar 

Gobba F. Olfactory toxicity: long-term effects of occupational exposures. Int Arch Occup Environ Health. 2006;79:322–31.

Article  CAS  PubMed  Google Scholar 

Rose CS, Heywood PG, Costanzo RM. Olfactory impairment after chronic occupational cadmium exposure. J Occup Med. 1992;34:600–5.

CAS  PubMed  Google Scholar 

Mascagni P, Consonni D, Bregante G, Chiappino G, Toffoletto F. Olfactory function in workers exposed to moderate airborne cadmium levels. Neurotoxicology. 2003;24:717–24.

Article  CAS  PubMed  Google Scholar 

Lucas EL, Bertrand P, Guazzetti S, Donna F, Peli M, Jursa TP, et al. Impact of ferromanganese alloy plants on household dust manganese levels: implications for childhood exposure. Environ Res. 2015;138:279–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lucchini RG, Guazzetti S, Zoni S, Donna F, Peter S, Zacco A, et al. Tremor, olfactory and motor changes in Italian adolescents exposed to historical ferro-manganese emission. Neurotoxicology. 2012;33:687–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bundy DAP, Silva ND, Horton S, Jamison DT, Patton GC. Child and Adolescent Health and Development. Washington (DC): The International Bank for Reconstruction and Development; The World Bank; 2017.

Werner S, Nies E. Olfactory dysfunction revisited: a reappraisal of work-related olfactory dysfunction caused by chemicals. J Occup Med Toxicol. 2018;13:28.

Article  PubMed  PubMed Central  Google Scholar 

Guo J, Zhou Y, Wang Y, Zhang B, Zhang J. Assessment of internal exposure to methylsiloxanes in children and associated non-dietary exposure risk. Environ Int. 2021;154:106672.

Article  CAS  PubMed  Google Scholar 

Khanam T, Eqani SAMA, Zhang J, Wang H, Zhang Y, Yang J, et al. Urinary profiles of selected metals and arsenic and their exposure pathway analysis in four large floodplains of Pakistan. Sci Total Environ. 2020;737:139586.

Article  CAS  PubMed  Google Scholar 

Zeng Y, Pan W, Ding N, Kang Y, Man YB, Zeng L, et al. Brominated flame retardants in home dust and its contribution to brominated flame retardants bioaccumulation in children hair. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2020;55:1528–33.

Article  CAS  PubMed  Google Scholar 

Teysseire R, Manangama G, Baldi I, Carles C, Brochard P, Bedos C, et al. Determinants of non-dietary exposure to agricultural pesticides in populations living close to fields: a systematic review. Sci Total Environ. 2021;761:143294.

Article  CAS  PubMed  Google Scholar 

Fan G, Xie J, Yoshino H, Zhang H, Li Z, Li N, et al. Common SVOCs in house dust from urban dwellings with schoolchildren in six typical cities of China and associated non-dietary exposure and health risk assessment. Environ Int. 2018;120:431–42.

Article  CAS  PubMed 

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