Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, van Kerrebroeck P, Victor A, Wein A. The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn. 2002;21(2):167–78.
Berry SJ, Coffey DS, Walsh PC, Ewing LL. The development of human benign prostatic hyperplasia with age. J Urol. 1984;132(3):474–9.
Article CAS PubMed Google Scholar
Sanda MG, Beaty TH, Stutzman RE, Childs B, Walsh PC. Genetic susceptibility of benign prostatic hyperplasia. J Urol. 1994;152(1):115–9.
Article CAS PubMed Google Scholar
Chughtai B, Forde JC, Thomas DD, Laor L, Hossack T, Woo HH, Te AE, Kaplan SA. Benign prostatic hyperplasia. Nat Rev Dis Primers. 2016;2:16031.
Afari N, Gasperi M, Forsberg CW, Goldberg J, Buchwald D, Krieger JN. Heritability of lower urinary tract symptoms in men: a twin study. J Urol. 2016;196(5):1486–92.
Article PubMed PubMed Central Google Scholar
Hellwege JN, Stallings S, Torstenson ES, Carroll R, Borthwick KM, Brilliant MH, Crosslin D, Gordon A, Hripcsak G, Jarvik GP, et al. Heritability and genome-wide association study of benign prostatic hyperplasia (BPH) in the eMERGE network. Sci Rep. 2019;9(1):6077.
Article PubMed PubMed Central Google Scholar
Chen ZP, Yan Y, Chen CJ, Li M, Chen C, Zhao SC, Song T, Liu T, Zou CH, Xu Q, et al. The single nucleotide polymorphism rs700518 is an independent risk factor for metabolic syndrome and benign prostatic hyperplasia (MetS-BPH). Andrology. 2018;6(4):568–78.
Article CAS PubMed PubMed Central Google Scholar
Ruan L, Zhu JG, Pan C, Hua X, Yuan DB, Li ZM, Zhong WD. Association between single nucleotide polymorphism of vitamin D receptor gene FokI polymorphism and clinical progress of benign prostatic hyperplasia. ScientificWorldJournal 2015, 2015:235895.
Tang J, Yang J. Etiopathogenesis of benign prostatic hypeprlasia. Indian J Urol. 2009;25(3):312–7.
Article PubMed PubMed Central Google Scholar
Jiao Y, Wang L, Gu X, Tao S, Tian L, Na R, Chen Z, Kang J, Zheng SL, Xu J, et al. LILRA3 is associated with benign prostatic hyperplasia risk in a Chinese Population. Int J Mol Sci. 2013;14(5):8832–40.
Article PubMed PubMed Central Google Scholar
Oh JJ, Byun SS, Lee SE, Hong SK, Jeong CW, Kim D, Kim HJ, Myung SC. Genetic variations in VDR associated with prostate cancer risk and progression in a Korean population. Gene. 2014;533(1):86–93.
Article CAS PubMed Google Scholar
Tanigawa Y, Qian J, Venkataraman G, Justesen JM, Li R, Tibshirani R, Hastie T, Rivas MA. Significant sparse polygenic risk scores across 813 traits in UK Biobank. PLoS Genet. 2022;18(3):e1010105.
Article CAS PubMed PubMed Central Google Scholar
Privé F, Aschard H, Carmi S, Folkersen L, Hoggart C, O’Reilly PF, Vilhjálmsson BJ. Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort. Am J Hum Genet. 2022;109(1):12–23.
Article PubMed PubMed Central Google Scholar
Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, Downey P, Elliott P, Green J, Landray M, et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 2015;12(3):e1001779.
Article PubMed PubMed Central Google Scholar
Michel MC, Vrydag W. Alpha1-, alpha2- and beta-adrenoceptors in the urinary bladder, urethra and prostate. Br J Pharmacol. 2006;147(Suppl 2):S88–119.
CAS PubMed PubMed Central Google Scholar
McConnell JD, Roehrborn CG, Bautista OM, Andriole GL Jr., Dixon CM, Kusek JW, Lepor H, McVary KT, Nyberg LM Jr., Clarke HS, et al. The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia. N Engl J Med. 2003;349(25):2387–98.
Article CAS PubMed Google Scholar
Roehrborn CG, Siami P, Barkin J, Damião R, Major-Walker K, Morrill B, Montorsi F. The effects of dutasteride, tamsulosin and combination therapy on lower urinary tract symptoms in men with benign prostatic hyperplasia and prostatic enlargement: 2-year results from the CombAT study. J Urol. 2008;179(2):616–21. discussion 621.
Article CAS PubMed Google Scholar
Roehrborn CG, Siami P, Barkin J, Damião R, Major-Walker K, Nandy I, Morrill BB, Gagnier RP, Montorsi F. The effects of combination therapy with dutasteride and tamsulosin on clinical outcomes in men with symptomatic benign prostatic hyperplasia: 4-year results from the CombAT study. Eur Urol. 2010;57(1):123–31.
Article CAS PubMed Google Scholar
Bruce A, Krishan A, Sadiq S, Ehsanullah SA, Khashaba S. Safety and Efficacy of Bipolar Transurethral Resection of the prostate vs monopolar transurethral resection of prostate in the treatment of moderate-large volume Prostatic Hyperplasia: a systematic review and Meta-analysis. J Endourol. 2021;35(5):663–73.
Torkamani A, Wineinger NE, Topol EJ. The personal and clinical utility of polygenic risk scores. Nat Rev Genet. 2018;19(9):581–90.
Article CAS PubMed Google Scholar
Lewis CM, Vassos E. Polygenic risk scores: from research tools to clinical instruments. Genome Med. 2020;12(1):44.
Article PubMed PubMed Central Google Scholar
Tamlander M, Mars N, Pirinen M, Widén E, Ripatti S. Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes. Commun Biol. 2022;5(1):158.
Article CAS PubMed PubMed Central Google Scholar
Xin J, Jiang X, Li H, Chen S, Zhang Z, Wang M, Gu D, Du M, Christiani DC. Prognostic evaluation of polygenic risk score underlying pan-cancer analysis: evidence from two large-scale cohorts. EBioMedicine. 2023;89:104454.
Article CAS PubMed PubMed Central Google Scholar
Gudmundsson J, Sigurdsson JK, Stefansdottir L, Agnarsson BA, Isaksson HJ, Stefansson OA, Gudjonsson SA, Gudbjartsson DF, Masson G, Frigge ML, et al. Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA. Nat Commun. 2018;9(1):4568.
Article PubMed PubMed Central Google Scholar
Fan CT, Lin JC, Lee CH. Taiwan Biobank: a project aiming to aid Taiwan’s transition into a biomedical island. Pharmacogenomics. 2008;9(2):235–46.
Wei CY, Yang JH, Yeh EC, Tsai MF, Kao HJ, Lo CZ, Chang LP, Lin WJ, Hsieh FJ, Belsare S, et al. Genetic profiles of 103,106 individuals in the Taiwan Biobank provide insights into the health and history of Han Chinese. NPJ Genom Med. 2021;6(1):10.
Article CAS PubMed PubMed Central Google Scholar
Das S, Forer L, Schönherr S, Sidore C, Locke AE, Kwong A, Vrieze SI, Chew EY, Levy S, McGue M, et al. Next-generation genotype imputation service and methods. Nat Genet. 2016;48(10):1284–7.
Article CAS PubMed PubMed Central Google Scholar
Auton A, Brooks LD, Durbin RM, Garrison EP, Kang HM, Korbel JO, Marchini JL, McCarthy S, McVean GA, Abecasis GR. A global reference for human genetic variation. Nature. 2015;526(7571):68–74.
Bycroft C, Freeman C, Petkova D, Band G, Elliott LT, Sharp K, Motyer A, Vukcevic D, Delaneau O, O’Connell J, et al. The UK Biobank resource with deep phenotyping and genomic data. Nature. 2018;562(7726):203–9.
Article CAS PubMed PubMed Central Google Scholar
Chang CC, Chow CC, Tellier LC, Vattikuti S, Purcell SM, Lee JJ. Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience. 2015;4:7.
Article PubMed PubMed Central Google Scholar
Prive F, Vilhjalmsson BJ, Aschard H, Blum MGB. Making the most of clumping and thresholding for polygenic scores. Am J Hum Genet. 2019;105(6):1213–21.
Article CAS PubMed PubMed Central Google Scholar
Marees AT, de Kluiver H, Stringer S, Vorspan F, Curis E, Marie-Claire C, Derks EM. A tutorial on conducting genome-wide association studies: quality control and statistical analysis. Int J Methods Psychiatr Res. 2018;27(2):e1608.
Article PubMed PubMed Central Google Scholar
Lambert SA, Gil L, Jupp S, Ritchie SC, Xu Y, Buniello A, McMahon A, Abraham G, Chapman M, Parkinson H, et al. The polygenic score catalog as an open database for reproducibility and systematic evaluation. Nat Genet. 2021;53(4):420–5.
Article CAS PubMed Google Scholar
Collister JA, Liu X, Clifton L. Calculating polygenic risk scores (PRS) in UK Biobank: a practical guide for epidemiologists. Front Genet. 2022;13:818574.
Article CAS PubMed PubMed Central Google Scholar
Partin AW, Page WF, Lee BR, Sanda MG, Miller RN, Walsh PC. Concordance rates for benign prostatic disease among twins suggest hereditary influence. Urology. 1994;44(5):646–50.
Comments (0)