A previously healthy, 19-year-old, female patient presented with a five-day history of progressive odynophagia, fever, and rash during the summer. She had contact with a 3-year-old child two days before symptom onset. A physical examination revealed vesicles and shallow ulcers surrounded by a thin, erythematous halo on her lips, tongue, buccal mucosa, and soft palate (Fig. 1A, B) and a maculopapular rash on her palms, forearms, soles, and buttocks (Fig. 2A–C). After laboratory tests ruled out