Paik JM, Golabi P, Younossi Y, Mishra A, Younossi ZM. Changes in the global burden of chronic liver diseases from 2012 to 2017: the growing impact of NAFLD. Hepatol Baltim Md 2020;72:1605–1616. https://doi.org/10.1002/hep.31173.

Article  Google Scholar 

Moon AM, Singal AG, Tapper EB. Contemporary epidemiology of chronic liver disease and cirrhosis. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc 2020;18:2650–2666. https://doi.org/10.1016/j.cgh.2019.07.060.

Article  Google Scholar 

Singh AD, Mucha SR, Lindenmeyer CC. Cirrhotic coagulopathy: a rebalanced hemostasis. Cleve Clin J Med 2022;89:523–533. https://doi.org/10.3949/ccjm.89a.21018.

Article  PubMed  Google Scholar 

Ambrosino P, Tarantino L, Di Minno G et al. The risk of venous thromboembolism in patients with cirrhosis. A systematic review and meta-analysis. Thromb Haemost 2017;117:139–148. https://doi.org/10.1160/TH16-06-0450.

Article  PubMed  Google Scholar 

Subhani M, Sheth A, Ahmed J et al. Incidence and prevalence of venous thromboembolism in chronic liver disease: a systematic review and meta-analysis. Thromb Res 2022;215:19–29. https://doi.org/10.1016/j.thromres.2022.05.004.

Article  CAS  PubMed  Google Scholar 

Wu H, Nguyen GC. Liver cirrhosis is associated with venous thromboembolism among hospitalized patients in a nationwide US study. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc 2010;8:800–805. https://doi.org/10.1016/j.cgh.2010.05.014.

Article  Google Scholar 

Wijarnpreecha K, Thongprayoon C, Panjawatanan P, Ungprasert P. Hepatitis C virus infection and risk of venous thromboembolism: a systematic review and meta-analysis. Ann Hepatol 2017;16:514–520. https://doi.org/10.5604/01.3001.0010.0279.

Article  CAS  PubMed  Google Scholar 

Stine JG, Niccum BA, Zimmet AN et al. Increased risk of venous thromboembolism in hospitalized patients with cirrhosis due to nonalcoholic steatohepatitis. Clin Transl Gastroenterol 2018;9:140. https://doi.org/10.1038/s41424-018-0002-y.

Article  PubMed  PubMed Central  Google Scholar 

Ng KJ, Lee YK, Huang MY, Hsu CY, Su YC. Risks of venous thromboembolism in patients with liver cirrhosis: a nationwide cohort study in Taiwan. J Thromb Haemost 2015;13:206–213. https://doi.org/10.1111/jth.12805.

Article  PubMed  Google Scholar 

Jepsen P, Tapper EB, Deleuran T et al. Risk and outcome of venous and arterial thrombosis in patients with cirrhosis: a danish nation-wide cohort study. Hepatol Baltim Md 2021;74:2725–2734. https://doi.org/10.1002/hep.32019.

Article  CAS  Google Scholar 

Bikdeli B, Jiménez D, Garcia-Tsao G et al. Venous Thromboembolism in patients with liver cirrhosis: findings from the RIETE (Registro Informatizado de la Enfermedad TromboEmbolica) Registry. Semin Thromb Hemost 2019;45:793–801. https://doi.org/10.1055/s-0039-1697682.

Article  PubMed  Google Scholar 

Søgaard KK, Horváth-Puhó E, Grønbaek H, Jepsen P, Vilstrup H, Sørensen HT. Risk of venous thromboembolism in patients with liver disease: a nationwide population-based case-control study. Am J Gastroenterol 2009;104:96–101. https://doi.org/10.1038/ajg.2008.34.

Article  PubMed  Google Scholar 

Molinari M, Fernandez-Carrillo C, Dai D et al. Portal vein thrombosis and renal dysfunction: a national comparative study of liver transplant recipients for NAFLD versus alcoholic cirrhosis. Transpl Int Off J Eur Soc Organ Transplant 2021;34:1105–1122. https://doi.org/10.1111/tri.13873.

Article  Google Scholar 

Stine JG, Shah NL, Argo CK, Pelletier SJ, Caldwell SH, Northup PG. Increased risk of portal vein thrombosis in patients with cirrhosis due to nonalcoholic steatohepatitis. Liver Transplant Off Publ Am Assoc Study Liver Dis Int Liver Transplant Soc 2015;21:1016–1021. https://doi.org/10.1002/lt.24134.

Article  Google Scholar 

Ambrosino P, Tarantino L, Criscuolo L, Nasto A, Celentano A, Di Minno MND. The risk of venous thromboembolism in patients with hepatitis C. A systematic review and meta-analysis. Thromb Haemost 2016;116:958–966. https://doi.org/10.1160/TH16-03-0185.

Article  PubMed  Google Scholar 

NRD Overview. Accessed March 21, 2019. https://www.hcup-us.ahrq.gov/nrdoverview.jsp

Hirode G, Saab S, Wong RJ. Trends in the burden of chronic liver disease among hospitalized US adults. JAMA Netw Open 2020;3:e201997. https://doi.org/10.1001/jamanetworkopen.2020.1997.

Article  PubMed  PubMed Central  Google Scholar 

Bengtsson B, Askling J, Ludvigsson JF, Hagström H. Validity of administrative codes associated with cirrhosis in Sweden. Scand J Gastroenterol 2020;55:1205–1210. https://doi.org/10.1080/00365521.2020.1820566.

Article  PubMed  Google Scholar 

Hayward KL, Johnson AL, Mckillen BJ et al. ICD-10-AM codes for cirrhosis and related complications: key performance considerations for population and healthcare studies. BMJ Open Gastroenterol 2020;7:e000485. https://doi.org/10.1136/bmjgast-2020-000485.

Article  PubMed  PubMed Central  Google Scholar 

Mapakshi S, Kramer JR, Richardson P, El-Serag HB, Kanwal F. Positive predictive value of international classification of diseases, 10th revision, codes for cirrhosis and its related complications. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc 2018;16:1677–1678. https://doi.org/10.1016/j.cgh.2018.01.042.

Article  Google Scholar 

Shearer JE, Gonzalez JJ, Min T et al. Systematic review: development of a consensus code set to identify cirrhosis in electronic health records. Aliment Pharmacol Ther 2022;55:645–657. https://doi.org/10.1111/apt.16806.

Article  PubMed  PubMed Central  Google Scholar 

Heit JA. Epidemiology of venous thromboembolism. Nat Rev Cardiol 2015;12:464–474. https://doi.org/10.1038/nrcardio.2015.83.

Article  PubMed  PubMed Central  Google Scholar 

Raskob GE, Angchaisuksiri P, Blanco AN et al. Thrombosis: a major contributor to the global disease burden. J Thromb Haemost 2014;12:1580–1590. https://doi.org/10.1111/jth.12698.

Article  Google Scholar 

Roberts LN, Hernandez-Gea V, Magnusson M et al. Thromboprophylaxis for venous thromboembolism prevention in hospitalized patients with cirrhosis: guidance from the SSC of the ISTH. J Thromb Haemost 2022;20:2237–2245. https://doi.org/10.1111/jth.15829.

Article  CAS  PubMed  Google Scholar 

Pant A, Kopec AK, Luyendyk JP. Role of the blood coagulation cascade in hepatic fibrosis. Am J Physiol Gastrointest Liver Physiol 2018;315:G171–G176. https://doi.org/10.1152/ajpgi.00402.2017.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Noureddin M, Vipani A, Bresee C et al. NASH leading cause of liver transplant in women: updated analysis of indications for liver transplant and ethnic and gender variances. Am J Gastroenterol 2018;113:1649–1659. https://doi.org/10.1038/s41395-018-0088-6.

Article  PubMed  PubMed Central  Google Scholar 

Ciavarella A, Gnocchi D, Custodero C et al. Translational insight into prothrombotic state and hypercoagulation in nonalcoholic fatty liver disease. Thromb Res 2021;198:139–150. https://doi.org/10.1016/j.thromres.2020.12.002.

Article  CAS  PubMed  Google Scholar 

Tripodi A, Lombardi R, Primignani M, La Mura V, Peyvandi F, Fracanzani AL. Hypercoagulability in patients with Nonalcoholic Fatty Liver Disease (NAFLD): causes and consequences. Biomedicines 2022;10:249. https://doi.org/10.3390/biomedicines10020249.

Article  CAS  PubMed  PubMed Central  Google Scholar 

van der Windt DJ, Sud V, Zhang H et al. Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis. Hepatology 2018;68:1347–1360. https://doi.org/10.1002/hep.29914.

Article  CAS  PubMed  Google Scholar 

Luci C, Bourinet M, Leclère PS, Anty R, Gual P. Chronic inflammation in nonalcoholic steatohepatitis: molecular mechanisms and therapeutic strategies. Front Endocrinol 2020;11:597648. https://doi.org/10.3389/fendo.2020.597648.

Article  Google Scholar 

Rivas G, Hummer-Bair B, Bezinover D, Kadry Z, Stine J. Plasminogen activator inhibitor is significantly elevated in liver transplant recipients with decompensated NASH cirrhosis. BMJ Open Gastroenterol 2021;8:e000683. https://doi.org/10.1136/bmjgast-2021-000683.

Article  PubMed  PubMed Central  Google Scholar 

Ogresta D, Mrzljak A, Cigrovski Berkovic M, Bilic-Curcic I, Stojsavljevic-Shapeski S, Virovic-Jukic L. Coagulation and endothelial dysfunction associated with NAFLD: current status and therapeutic implications. J Clin Transl Hepatol 2022;10:339–355. https://doi.org/10.14218/JCTH.2021.00268.

Article  PubMed  PubMed Central  Google Scholar