The level of energy and its delivery mode give ultrasound a variety of physical effects that can interact with biological tissue. From diagnosis using low intensity linear transducers to therapy using high-intensity pulsed or continuous focused ultrasound, the possibilities are vast. The anatomical characteristics of the eye require the use of fine focal spots, the minimization of heating and the consideration of eye movements in the design of devices. Ultrasound is the daily routine of the ophthalmologist with the use of ultrasonography which can be complementary to the optical clinical examination when the optical transparency of the media is lacking. Ultrasound imaging can also provide quantitative information on tissue composition (attenuation, elasticity, density...) or blood flow (Doppler effect). Ultrasound can micro-fragment the lens tissue, making cataract surgery less invasive, and performed in an outpatient basis worldwide. The selective and controlled burning of the ciliary bodies to lower the intraocular pressure of glaucoma has gained in safety, reproducibility and predictability thanks to the action of high intensity focused ultrasound (HIFU) independent of tissue pigmentation. The mechanisms of action at the origin of the biological effects are not always elucidated because they are complex and multiple. The creation of mechanical cavitations by the pulsed delivery of ultrasound opens the way to the transient rupture of biological barriers, thus increasing the penetrability of drugs. However, it remains at the stage of preclinical studies. The objective of this article is to review the diversity of ultrasound applications in ophthalmology today and tomorrow.
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