Contact leukoderma, also known as contact vitiligo, chemical leukoderma, or chemical or contact depigmentation, is an acquired cutaneous pigment loss resulting from repeated exposure to specific chemical compounds, particularly certain phenol and catechol derivatives. Another common cause is an allergy to nickel. As suggested by previous reports, upregulation of reactive oxygen species, melanocyte defects, and individual genetic predisposition jointly play a role in contact leukoderma.1 Kim