Structure-guided identification and characterization of potent inhibitors targeting PhoP and MtrA to combat mycobacteria
AbbreviationsCADD
Computer-aided drug design
CADDD
Computer-aided drug discovery and development
FP
Fluorescence polarization
LB
Luria-Bertani, LBDD, Ligand-based drug design
LSPR
Localized surface plasmon resonance
MD
Molecular dynamics, MDR, Multi-drug-resistant
MIC
Minimum inhibitory concentration
RMSD
Root mean square deviation
RMSF
Root mean square fluctuation
SBDD
Structure-based drug design
Keywords
Tuberculosis
Drug-resistant tuberculosis
Two-component signal transduction systems
Pharmacophore-based inhibitor screening
Mycobacteria
© 2024 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.
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