Coppens SJR, Zawodny Z, Dewinter G, Neyrinck A, Balocco AL, Rex S. In search of the Holy Grail: poisons and extended release local anesthetics. Best Pract Res Clin Anaesthesiol. 2019;33(1):3–21.

Article  PubMed  Google Scholar 

Ayyanaar S, Kesavan MP. Magnetic iron oxide nanoparticles@lecithin/poly (l-lactic acid) microspheres for targeted drug release in cancer therapy [published online ahead of print, 2023 Oct 18]. Int J Biol Macromol. 2023;253(Pt 7):127480.

Ben-Akiva E, Karlsson J, Hemmati S, Yu H, Tzeng SY, Pardoll DM, Green JJ. Biodegradable lipophilic polymeric mRNA nanoparticles for ligand-free targeting of splenic dendritic cells for cancer vaccination. Proc Natl Acad Sci U S A. 2023;120(26):e2301606120.

Article  PubMed  PubMed Central  Google Scholar 

Li H, Zhang X, Zhao W, Cai F, Qin J, Tian J. Efficacy of CalliSpheres® microspheres versus conventional transarterial chemoembolization in the treatment of refractory colorectal cancer liver metastasis. BMC Cancer. 2023;23(1):970.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Korde BA, Mankar JS, Phule S, Krupadam RJ. Nanoporous imprinted polymers (nanoMIPs) for controlled release of cancer drug. Mater Sci Eng C Mater Biol Appl. 2019;99:222–30.

Article  CAS  PubMed  Google Scholar 

Wang C, Zeng Y, Chen KF, Lin J, Yuan Q, Jiang X, Wu G, Wang F, Jia YG, Li W. A self-monitoring microneedle patch for light-controlled synergistic treatment of melanoma. Bioact Mater. 2023;27:58–71.

CAS  PubMed  PubMed Central  Google Scholar 

Kumbhar PS, Manjappa AS, Shah RR, Nadaf SJ, Disouza JI. Nanostructured lipid carrier-based gel for repurposing simvastatin in localized treatment of breast cancer: formulation design, development, and in vitro and in vivo characterization. AAPS PharmSciTech. 2023;24(5):106.

Article  CAS  PubMed  Google Scholar 

Zhou L, Feng W, Mao Y, Chen Y, Zhang X. Nanoengineered sonosensitive platelets for synergistically augmented sonodynamic tumor therapy by glutamine deprivation and cascading thrombosis. Bioact Mater. 2022;24:26–36.

PubMed  PubMed Central  Google Scholar 

Xu X, Chang S, Zhang X, Hou T, Yao H, Zhang S, Zhu Y, Cui X, Wang X. Fabrication of a controlled-release delivery system for relieving sciatica nerve pain using an ultrasound-responsive microcapsule. Front Bioeng Biotechnol. 2022;10:1072205.

Article  PubMed  PubMed Central  Google Scholar 

Xu Q, Chin SE, Wang CH, Pack DW. Mechanism of drug release from double-walled PDLLA(PLGA) microspheres. Biomaterials. 2013;34(15):3902–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hsu YH, Chen DW, Li MJ, Yu YH, Chou YC, Liu SJ. Sustained delivery of analgesic and antimicrobial agents to knee joint by direct injections of electrosprayed multipharmaceutical-loaded nano/microparticles. Polymers (Basel). 2018;10(8):890.

Article  PubMed  Google Scholar 

Guo Y, Logan HL, Glueck DH, Muller KE. Selecting a sample size for studies with repeated measures. BMC Med Res Methodol. 2013;13:100.

Article  PubMed  PubMed Central  Google Scholar 

Lipengolts AA, Finogenova YA, Skribitsky VA, Shpakova KE, Anaki A, Motiei M, Semkina AS, Abakumov MA, Smirnova AV, Grigorieva EY, Popovtzer R. CT and MRI Imaging of Theranostic Bimodal Fe3O4@Au NanoParticles in Tumor Bearing Mice. Int J Mol Sci. 2022;24(1):70.

Article  PubMed  PubMed Central  Google Scholar 

Yamasaki T, Fujiwara H, Oda R, Mikami Y, Ikeda T, Nagae M, Shirai T, Morisaki S, Ikoma K, Masugi-Tokita M, Yamada K. In vivo evaluation of rabbit sciatic nerve regeneration with diffusion tensor imaging (DTI): correlations with histology and behavior. Magn Reson Imaging. 2015;33(1):95–101.

Article  PubMed  Google Scholar 

Chou AK, Chiu CC, Chen YW, Wang JJ, Hung CH. Phentolamine reverses epinephrine-enhanced skin antinociception of dibucaine in rats. Anesth Analg. 2019;128(6):1336–43.

Article  CAS  PubMed  Google Scholar 

Tzeng JI, Wang JN, Wang JJ, Chen YW, Hung CH. Cutaneous synergistic analgesia of bupivacaine in combination with dopamine in rats. Neurosci Lett. 2016;620:88–92.

Article  CAS  PubMed  Google Scholar 

Wang J, Helder L, Shao J, Jansen JA, Yang M, Yang F. Encapsulation and release of doxycycline from electrospray-generated PLGA microspheres: effect of polymer end groups. Int J Pharm. 2019;564:1–9.

Article  CAS  PubMed  Google Scholar 

Malpezzi-Marinho ELA, Zanoni CIS, Molska GR, Paraventi C, Wuo-Silva R, Berro LF, Parada CA, Tamura EK, Marinho EA. Antinociceptive Activity of the Skin Secretion of Phyllomedusa rohdei (Amphibia, Anura). Toxins (Basel). 2020;12(9):589.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kau YC, Liao CC, Chen YC, Liu SJ. Sustained release of lidocaine from solvent-free biodegradable poly[(d,l)-Lactide-co-Glycolide] (PLGA): in vitro and in vivo study. materials (Basel). 2014;7(9):6660–76.

Zhang X, Dang M, Zhang W, Lei Y, Zhou W. Sustained delivery of prilocaine and lidocaine using depot microemulsion system: in vitro, ex vivo and in vivo animal studies. Drug Dev Ind Pharm. 2020;46(2):264–71.

Article  PubMed  Google Scholar 

Svirskis D, Chandramouli K, Bhusal P, Wu Z, Alphonso J, Chow J, Patel D, Ramakrishna R, Yeo SJ, Stowers R, Hill A. Injectable thermosensitive gelling delivery system for the sustained release of lidocaine [published correction appears in Ther Deliv. 2016;7(7):511]. Ther Deliv. 2016;7(6):359–68.

Bnyan R, Khan I, Ehtezazi T, Saleem I, Gordon S, O’Neill F, Roberts M. Formulation and optimisation of novel transfersomes for sustained release of local anaesthetic. Pharm Pharmacol. 2019;71(10):1508–19.

Article  CAS  Google Scholar 

Wen K, Na X, Yuan M, Bazybek N, Li X, Wei Y, Ma G. Preparation of novel ropivacaine hydrochloride-loaded PLGA microspheres based on post-loading mode and efficacy evaluation. Colloids Surf B Biointerfaces. 2022;210:112215.

Article  CAS  PubMed  Google Scholar 

Essa D, Kondiah PPD, Choonara YE, Pillay V. The design of poly(lactide-co-glycolide) nanocarriers for medical applications. Front Bioeng Biotechnol. 2020;8:48.

Article  PubMed  PubMed Central  Google Scholar 

Su Y, Liu J, Tan S, Liu W, Wang R, Chen C. PLGA sustained-release microspheres loaded with an insoluble small-molecule drug: microfluidic-based preparation, optimization, characterization, and evaluation in vitro and in vivo. Drug Deliv. 2022;29(1):1437–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu W, Chen L, Wu Z, Li W, Liu X, Wang Y, Guo M, Ito Y, Wang L, Zhang P, Wang H. Bioorthogonal DOPA-NGF activated tissue engineering microunits for recovery from traumatic brain injury by microenvironment regulation. Acta Biomater. 2022;150:67–82.

Article  CAS  PubMed  Google Scholar 

Manto KM, Govindappa PK, Martinazzi B, Han A, Hegarty JP, Koroneos Z, Talukder MH, Elfar JC. Erythropoietin-PLGA-PEG as a local treatment to promote functional recovery and neurovascular regeneration after peripheral nerve injury. J Nanobiotechnol. 2022;20(1):461.

Article  CAS  Google Scholar 

Yu M, Yuan W, Xia Z, Liu Y, Wang Y, Xu X, Zheng J, Schwendeman A. Characterization of exparel bupivacaine multivesicular liposomes. Int J Pharm. 2023;639:122952.

Article  CAS  PubMed  Google Scholar 

Blair HA. Bupivacaine/meloxicam prolonged release: a review in postoperative pain. Drugs. 2021;81(10):1203–11.

Article  CAS  PubMed  Google Scholar 

Vangijzegem T, Stanicki D, Laurent S. Magnetic iron oxide nanoparticles for drug delivery: applications and characteristics. Expert Opin Drug Deliv. 2019;16(1):69–78.

Article  CAS  PubMed  Google Scholar 

Zhao S, Yu X, Qian Y, Chen W, Shen J. Multifunctional magnetic iron oxide nanoparticles: an advanced platform for cancer theranostics. Theranostics. 2020;10(14):6278–309.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wainwright TW, Gill M, Mcdonald DA, Middleton RG, Reed M, Sahota O, Yates P, Ljungqvist O. Consensus statement for perioperative care in total hip replacement and total knee replacement surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations. Acta Orthop. 2020;91(1):3–19.

Article  PubMed  Google Scholar 

Frassanito L, Vergari A, Nestorini R, Cerulli G, Placella G, Pace V. Enhanced recovery after surgery (ERAS) in hip and knee replacement surgery: description of a multidisciplinary program to improve management of the patients undergoing major orthopedic surgery. Musculoskelet Surg. 2020;104(1):87–92.

Article  CAS  PubMed  Google Scholar 

Chen Q, Ma X, Xie L, Chen W, Xu Z, Song E, Zhu X, Song Y. Iron-based nanoparticles for MR imaging-guided ferroptosis in combination with photodynamic therapy to enhance cancer treatment. Nanoscale. 2021;13(9):4855–70.

Article  CAS  PubMed  Google Scholar 

Tousi MS, Sepehri H, Khoee S, Farimani MM, Delphi L, Mansourizadeh F. Evaluation of apoptotic effects of mPEG-b-PLGA coated iron oxide nanoparticles as a eupatorin carrier on DU-145 and LNCaP human prostate cancer cell lines. J Pharm Anal. 2021;11(1):108–21.

Article  PubMed  Google Scholar 

Peng F, Liu J, Zhang Y, Fan J, Gong D, He L, Zhang W, Qiu F. Designer self-assembling peptide nanofibers induce biomineralization of lidocaine for slow-release and prolonged analgesia. Acta Biomater. 2022;146:66–79.

Article  CAS  PubMed  Google Scholar