Dweck MR, Boon NA, Newby DE (2012) Calcific aortic stenosis: a disease of the valve and the myocardium. J Am Coll Cardiol 60(19):1854–1863

Article  PubMed  Google Scholar 

Coffey S, Cox B, Williams MJA (2014) The prevalence, incidence, progression, and risks of aortic valve sclerosis: a systematic review and meta-analysis. J Am Coll Cardiol 63(25):2852–2861

Article  PubMed  Google Scholar 

Osnabrugge RLJ, Mylotte D, Head SJ, Mieghem NMV, Nkomo VT, LeReum CM, Bogers AJJC, Piazza N, Kappetein AP (2013) Aortic stenosis in the elderly: disease prevalence and number of candidates for transcatheter aortic valve replacement: a meta-analysis and modeling study. J Am Coll Cardiol 62(11):1002–1012

Article  PubMed  Google Scholar 

Ross J, Braunwald E (1968) Aortic stenosis. Circulation 38(1):61–67

PubMed  Google Scholar 

Chan KL, Teo K, Dumesnil JG, Ni A, Tam J (2010) Effect of lipid lowering with rosuvastatin on progression of aortic stenosis. Circulation 121(2):306–314

Article  CAS  PubMed  Google Scholar 

Cowell SJ, Newby DE, Prescott RJ, Bloomfield P, Reid J, Northridge DB, Boon NA (2005) A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis. N Engl J Med 352(23):2389–2397

Article  CAS  PubMed  Google Scholar 

Rossebø AB, Pedersen TR, Boman K, Brudi P, Chambers JB, Egstrup K, Gerdts E, Gohlke-Bärwolf C, Holme I, Kesäniemi YA, Malbecq W, Nienaber CA, Ray S, Skjaerpe T, Wachtell K, Willenheimer R (2008) Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med 359(13):1343–2135

Article  PubMed  Google Scholar 

Kaiser Y, van der Toorn JE, Singh SS, Zheng KH, Kavousi M, Sijbrands EJG, Stroes ESG, Vernooij MW, de Rijke YB, Boekholdt SM, Bos D (2022) Lipoprotein(a) is associated with the onset but not the progression of aortic valve calcification. Eur Heart J 43(39):3960–3967

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kronenberg F (2022) Lipoprotein(a) and aortic valve stenosis: work in progress. Eur Heart J 43(39):3968–3970

Article  PubMed  Google Scholar 

Zheng KH, Tsimikas S, Pawade T, Kroon J, Jenkins WSA, Doris M, White AC, Timmers NKLM, Hjortnaes J, Rogers MA, Aikawa E, Arsenault BJ, Witztum J, Newby DE, Koschinsky ML, Fayad ZA, Stroes ESG, Boekholdt SM, Dweck MR (2019) Lipoprotein(a) and oxidized phospholipids promote valve calcification in patients with aortic stenosis. J Am Coll Cardiol 73(17):2150–2162

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thanassoulis G, Campbell CY, Owens DS, Smith JG, Smith AV, Peloso GM, Kerr KF, Pechlivanis S, Budoff MJ, Harris TB, Malhotra R, O’Brien KD, Kamstrup PR, Nordestgaard BG, Tybjaerg-Hansen A, Allison MA, Aspelund T, Criqui MH, Heckbert SR, Hwang SJ, Liu Y, Sjogren M, van der Pals J, Kälsch H, Mühleisen TW, Nöthen MM, Cupples LA, Caslake M, Di Angelantonio E, Danesh J, Rotter JI, Sigurdsson S, Wong Q, Erbel R, Kathiresan S, Melander O, Gudnason V, O’Donnell CJ, Post WS (2013) Genetic associations with valvular calcification and aortic stenosis. N Engl J Med 368(6):503–512

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kiyosue A, Honarpour N, Kurtz C, Xue A, Wasserman SM, Hirayama A (2016) A phase 3 study of evolocumab (AMG 145) in statin-treated Japanese patients at high cardiovascular risk. Am J Cardiol 117(1):40–47

Article  CAS  PubMed  Google Scholar 

Tsimikas S, Gordts PLSM, Nora C, Yeang C, Witztum JL (2020) Statin therapy increases lipoprotein(a) levels. Eur Heart J41(24):2275–2284

Article  Google Scholar 

O’Donoghue ML, Fazio S, Giugliano RP, Stroes ESG, Kanevsky E, Gouni-Berthold I, Im KA, Pineda AL, Wasserman SM, Češka R, Ezhov MV, Jukema JW, Jensen HK, Tokgözoğlu SL, Mach F, Huber K, Sever PS, Keech AC, Pedersen TR, Sabatine MS (2019) Lipoprotein(a), PCSK9 inhibition, and cardiovascular risk. Circulation 139(12):1483–1492

Article  PubMed  Google Scholar 

Bergmark BA, O’Donoghue ML, Murphy SA, Kuder JF, Ezhov MV, Češka R, Gouni-Berthold I, Jensen HK, Tokgozoglu SL, MacH F, Huber K, Gaciong Z, Lewis BS, Schiele F, Jukema JW, Pedersen TR, Giugliano RP, Sabatine MS (2020) An exploratory analysis of proprotein convertase subtilisin/kexin type 9 inhibition and aortic stenosis in the FOURIER Trial. JAMA Cardio 5(6):709–713

Article  Google Scholar 

Vahanian A, Beyersdorf F, Praz F, Milojevic M, Baldus S, Bauersachs J, Capodanno D, Conradi L, De Bonis M, De Paulis R, Delgado V, Freemantle N, Gilard M, Haugaa KH, Jeppsson A, Jüni P, Pierard L, Prendergast BD, Sadaba JR, Tribouilloy C, Wojakowski W, Neumann FJ, Myers P, Abdelhamid M, Achenbach S, Asteggiano R, Barili F, Borger MA, Carrel T, Collet JP, Foldager D, Habib G, Hassager C, Irs A, Iung B, Jahangiri M, Katus HA, Koskinas KC, Massberg S, Mueller CE, Nielsen JC, Pibarot P, Rakisheva A, Roffi M, Rubboli A, Shlyakhto E, Siepe M, Sitges M, Sondergaard L, Sousa-Uva M, Tarantini G, Zamorano JL, Benchabi Y, Chilingaryan A, Metzler B, Rustamova Y, Shumavets V, Lancellotti P, Smajic E, Trendafilova-Lazarova D, Samardzic J, Karakyriou M, Palecek T, Dahl JS, Meshaal MS, Palm K, Virtanen M, Bouleti C, Bakhutashvili Z, Boutsikou M, Kertész AB, Danielsen R, Topilsky Y, Golino P, Tuleutayev R, Elezi S, Kerimkulova A, Rudzitis A, Glaveckaite S, Sow R, Demarco DC, Bulatovic N, Aouad A, Van Den Brink R, Antova E, Beitnes JO, Ochala A, Ribeiras R, Vinereanu D, Irtyuga O, Ivanovic B, Simkova I, Gomez AG, Sarno G, Pedrazzini GB, Bsata W, Zakhama L, Korkmaz L, Cherniuk S, Khanji MY, Sharipov I, Baigent C, Aboyans V, Antoniou S, Arbelo E, Baumbach A, Čelutkiene J, Cikes M, Falk V, Fauchier L, Gale CP, Halvorsen S, Jaarsma T, Konradi A, Kotecha D, Landmesser U, Lewis BS, Linhart A, Løchen ML, Neubeck L, Petersen SE, Prescott E, Touyz RM, Galletti L, Hazekamp M, Licht P, Perier P, Prager R, Roessner E, Tsagakis K, Zientara A (2022) 2021 ESC/EACTS guidelines for the management of valvular heart disease developed by the task force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J 43(7):561–632

Article  PubMed  Google Scholar 

Baumgartner H, Hung J, Bermejo J, Chambers JB, Edvardsen T, Goldstein S, Lancellotti P, LeFevre M, Miller F, Otto CM (2017) Recommendations on the echocardiographic assessment of aortic valve stenosis: a focused update from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. J Am Soc Echocardiogr 30(4):372–392

Article  PubMed  Google Scholar 

Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD, Mickley H, Crea F, Van De Werf F, Bucciarelli-Ducci C, Katus HA, Pinto FJ, Antman EM, Hamm CW, De Caterina R, Januzzi JL, Apple FS, Garcia MAA, Underwood SR, Canty JM, Lyon AR, Devereaux PJ, Zamorano JL, Lindahl B, Weintraub WS, Newby LK, Virmani R, Vranckx P, Cutlip D, Gibbons RJ, Smith SC, Atar D, Luepker RV, Robertson RM, Bonow RO, Steg PG, O’Gara PT, Fox KAA, Hasdai D, Aboyans V, Achenbach S, Agewall S, Alexander T, Avezum A, Barbato E, Bassand JP, Bates E, Bittl JA, Breithardt G, Bueno H, Bugiardini R, Cohen MG, Dangas G, De Lemos JA, Delgado V, Filippatos G, Fry E, Granger CB, Halvorsen S, Hlatky MA, Ibanez B, James S, Kastrati A, Leclercq C, Mahaffey KW, Mehta L, Müller C, Patrono C, Piepoli MF, Piñeiro D, Roffi M, Rubboli A, Sharma S, Simpson IA, Tendera M, Valgimigli M, Van Der Wal AC, Windecker S (2019) Fourth universal definition of myocardial infarction (2018). Eur Heart J 40(3):237–269

Article  PubMed  Google Scholar 

Stewart BF, Siscovick D, Lind BK, Gardin JM, Gottdiener JS, Smith VE, Kitzman DW, Otto CM (1997) Clinical factors associated with calcific aortic valve disease. J Am Coll Cardiol 29(3):630–634

Article  CAS  PubMed  Google Scholar 

Rajamannan NM, Bonow RO, Rahimtoola SH (2007) Calcific aortic stenosis: an update. Nat Clin Pract Cardiovasc Med 4(5):254–262

Article  CAS  PubMed  Google Scholar 

Luis MM, Sandra FR, José LZ, Isabel MB, Luis FA, Francisco RG, Nalini MR (2007) Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis. J Am Coll Cardiol 49(5):554–561

Article  Google Scholar 

Zhao Y, Nicoll R, He YH, Henein MY (2016) The effect of statins on valve function and calcification in aortic stenosis: a meta-analysis. Atherosclerosis 246:318–324

Article  CAS  PubMed  Google Scholar 

Kensuke M, Olivier M, Patrick O (2023) Contemporary issues and lifetime management in patients underwent transcatheter aortic valve replacement. Cardiovasc Interv Ther 38(3):275–286

Article  Google Scholar 

Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O’Brien KD, Schoen FJ, Towler DA, Yoganathan AP, Otto CM (2011) Calcific aortic valve disease: not simply a degenerative process. Circulation 124(16):1783–1791

Article  PubMed  PubMed Central  Google Scholar 

Mazière C, Louvet L, Gomila C, Kamel S, Massy Z, Mazière JC (2009) Oxidized low density lipoprotein decreases Rankl-induced differentiation of osteoclasts by inhibition of Rankl signaling. J Cell Physiol 221(3):572–578

Article  PubMed  Google Scholar 

Derwall M, Malhotra R, Lai CS, Beppu Y, Aikawa E, Seehra JS, Zapol WM, Bloch KD, Yu PB (2012) Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arterioscler Thromb Vasc Biol 32(3):613–662

Article  CAS  PubMed  Google Scholar 

Demer L, Tintut Y (2011) The roles of lipid oxidation products and receptor activator of nuclear factor-kappa B signaling in atherosclerotic calcification. Circ Res 108(12):1482

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hung MY, Witztum JL, Tsimikas S (2014) New therapeutic targets for calcific aortic valve stenosis: the lipoprotein(a)-lipoprotein-associated phospholipase A2-oxidized phospholipid axis. J Am Coll Cardiol 63(5):478–480

Article  PubMed  Google Scholar 

Bittner VA, Szarek M, Aylward PE, Bhatt DL, Diaz R, Edelberg JM, Fras Z, Goodman SG, Halvorsen S, Hanotin C, Harrington RA, Jukema JW, Loizeau V, Moriarty PM, Moryusef A, Pordy R, Roe MT, Sinnaeve P, Tsimikas S, Vogel R, White HD, Zahger D, Zeiher AM, Steg PG, Schwartz GG (2020) Effect of alirocumab on lipoprotein(a) and cardiovascular risk after acute coronary syndrome. J Am Coll Cardiol 75(2):133–144

Article  CAS  PubMed  Google Scholar 

Willner N, Prosperi-Porta G, Lau L, Nam Fu AY, Boczar K, Poulin A, Di Santo P, Unni RR, Visintini S, Ronksley PE, Chan KL, Beauchesne L, Burwash IG, Messika-Zeitoun D (2023) Aortic stenosis progression: a systematic review and meta-analysis. JACC Cardiovasc Imaging 16(3):314–328

Article  PubMed  Google Scholar