CC BY-NC-ND 4.0 · Semin Respir Crit Care Med 2024; 45(01): 003-020
DOI: 10.1055/s-0043-1777259
Iris Janssens
1
Department of Internal Medicine and Paediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
2
Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
3
VIB Center for Inflammation Research, Ghent, Belgium
,
Bart N. Lambrecht
1
Department of Internal Medicine and Paediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
2
Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
3
VIB Center for Inflammation Research, Ghent, Belgium
4
Department of Pulmonary Medicine, ErasmusMC; Rotterdam, The Netherlands
,
Eva Van Braeckel
1
Department of Internal Medicine and Paediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
2
Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
› Author Affiliations
Funding I.J., B.N.L., and E.V.B. receive funding from an EOS consortium grant (G0H1222N) and the Forton Fund and Belgian Cystic Fibrosis Association through the King Baudouin Foundation.
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Abstract
The filamentous fungus Aspergillus causes a wide spectrum of diseases in the human lung, with Aspergillus fumigatus being the most pathogenic and allergenic subspecies. The broad range of clinical syndromes that can develop from the presence of Aspergillus in the respiratory tract is determined by the interaction between host and pathogen. In this review, an oversight of the different clinical entities of pulmonary aspergillosis is given, categorized by their main pathophysiological mechanisms. The underlying immune processes are discussed, and the main clinical, radiological, biochemical, microbiological, and histopathological findings are summarized.
Keywords
Aspergillus
-
Aspergillus fumigatus
-
immunology -
pathophysiology
Publication History
Article published online:
29 January 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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