Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72:7–33.

Article  PubMed  Google Scholar 

Dyba T, Randi G, Bray F, Martos C, Giusti F, Nicholson N, et al. The European cancer burden in 2020: incidence and mortality estimates for 40 countries and 25 major cancers. Eur J Cancer. 2021;157:308–47.

Article  PubMed  PubMed Central  Google Scholar 

Sher DJ. Neoadjuvant chemoradiotherapy for stage III non-small cell lung cancer. Front Oncol. 2017;7:281.

Article  PubMed  PubMed Central  Google Scholar 

NSCLC Meta-analysis Collaborative Group. Preoperative chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of individual participant data. Lancet. 2014;383:1561–71.

Article  PubMed Central  Google Scholar 

Albain KS, Swann RS, Rusch VW, Turrisi AT 3rd, Shepherd FA, Smith C, et al. Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial. Lancet. 2009;374:379–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Toyooka S, Kiura K, Shien K, Katsui K, Hotta K, Kanazawa S, et al. Induction chemoradiotherapy is superior to induction chemotherapy for the survival of non-small-cell lung cancer patients with pathological mediastinal lymph node metastasis. Interact Cardiovasc Thorac Surg. 2012;15:954–60.

Article  PubMed  PubMed Central  Google Scholar 

Toyooka S, Kiura K, Takemoto M, Oto T, Takigawa N, Fujiwara T, et al. Long-term outcome of induction chemoradiotherapy with docetaxel and cisplatin followed by surgery for non-small-cell lung cancer with mediastinal lymph node metastasis. Interact Cardiovasc Thorac Surg. 2012;14:565–9.

Article  PubMed  PubMed Central  Google Scholar 

Peng F, Hu D, Lin X, Chen G, Liang B, Li C, et al. The monocyte to red blood cell count ratio is a strong predictor of postoperative survival in colorectal cancer patients: the Fujian prospective investigation of cancer (FIESTA) study. J Cancer. 2017;8:967–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zou ZY, Liu HL, Ning N, Li SY, Du XH, Li R. Clinical significance of pre-operative neutrophil lymphocyte ratio and platelet lymphocyte ratio as prognostic factors for patients with colorectal cancer. Oncol Lett. 2016;11:2241–8.

Article  PubMed  PubMed Central  Google Scholar 

Gu XB, Tian T, Tian XJ, Zhang XJ. Prognostic significance of neutrophil-to-lymphocyte ratio in non-small cell lung cancer: a meta-analysis. Sci Rep. 2015;5:12493.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Templeton AJ, McNamara MG, Šeruga B, Vera-Badillo FE, Aneja P, Ocaña A, et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst. 2014;106:dju124.

Article  PubMed  Google Scholar 

Luo G, Guo M, Liu Z, Xiao Z, Jin K, Long J, et al. Blood neutrophil-lymphocyte ratio predicts survival in patients with advanced pancreatic cancer treated with chemotherapy. Ann Surg Oncol. 2015;22:670–6.

Article  PubMed  Google Scholar 

Yamamoto H, Namba K, Yamamoto H, Toji T, Soh J, Shien K, et al. The neutrophil-to-lymphocyte ratio as a novel independent prognostic factor for multiple metastatic lung tumors from various sarcomas. Surg Today. 2021;51:127–35.

Article  CAS  PubMed  Google Scholar 

Guo D, Han A, Jing W, Chen D, Jin F, Li M, et al. Preoperative to postoperative change in neutrophil-to-lymphocyte ratio predict survival in colorectal cancer patients. Future Oncol. 2018;14:1187–96.

Article  CAS  PubMed  Google Scholar 

Jin F, Han A, Shi F, Kong L, Yu J. The postoperative neutrophil-to-lymphocyte ratio and changes in this ratio predict survival after the complete resection of stage I non-small cell lung cancer. Onco Targets Ther. 2016;9:6529–37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsudaka S, Yamamoto H, Sato H, Katsui K, Suzawa K, Shien K, et al. Prognostic significance of neutrophil-to-lymphocyte ratio in locally advanced non-small-cell lung cancer treated with trimodality therapy. Ann Surg Oncol. 2021;28:4880–90.

Article  PubMed  Google Scholar 

Shan J, Xie X, Gu B, Sun X, Liu H. Inflammation index predicts radiation-induced lung injury and prognosis in lung tumors treated with stereotactic body radiation therapy. Jpn J Radiol. 2023;42:102–8.

Article  PubMed  Google Scholar 

Pan WY, Bian C, Zou GL, Zhang CY, Hai P, Zhao R, et al. Combing NLR, V20 and mean lung dose to predict radiation induced lung injury in patients with lung cancer treated with intensity modulated radiation therapy and chemotherapy. Oncotarget. 2017;8:81387–93.

Article  PubMed  PubMed Central  Google Scholar 

Lee YH, Choi HS, Jeong H, Kang KM, Song JH, Lee WS, et al. Neutrophil-lymphocyte ratio and a dosimetric factor for predicting symptomatic radiation pneumonitis in non-small-cell lung cancer patients treated with concurrent chemoradiotherapy. Clin Respir J. 2018;12:1264–73.

Article  CAS  PubMed  Google Scholar 

Eba J, Nakamura K. Overview of the ethical guidelines for medical and biological research involving human subjects in Japan. Jpn J Clin Oncol. 2022;52:539–44.

Article  PubMed  PubMed Central  Google Scholar 

Goldstraw P, Chansky K, Crowley J, Rami-Porta R, Asamura H, Eberhardt WE, et al. The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer. J Thorac Oncol. 2016;11:39–51.

Article  PubMed  Google Scholar 

Amin MB, Edge SB, Greene FL, Byrd DR, Brookland RK, Washington MK, et al. AJCC cancer staging manual. 8th ed. Cham: Springer; 2017.

Google Scholar 

Brierley JD, Gospodarowicz MK, Wittekind C. TNM classification of malignant tumours. 8th ed. Oxford: Wiley; 2017.

Google Scholar 

U.S. Department of Health and Human Services NIH, National Cancer Institute,. Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0. https://ctep.cancer.gov/protocolDevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_5x7.pdf. Accessed 25 Dec 2022.

Katayama H, Ueoka H, Kiura K, Tabata M, Kozuki T, Tanimoto M, et al. Preoperative concurrent chemoradiotherapy with cisplatin and docetaxel in patients with locally advanced non-small-cell lung cancer. Br J Cancer. 2004;90:979–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Torigoe H, Soh J, Tomida S, Namba K, Sato H, Katsui K, et al. Induction chemoradiotherapy using docetaxel and cisplatin with definitive-dose radiation followed by surgery for locally advanced non-small cell lung cancer. J Thorac Dis. 2017;9:3076–86.

Article  PubMed  PubMed Central  Google Scholar 

Katsui K, Ogata T, Watanabe K, Katayama N, Soh J, Kuroda M, et al. Dose-volume parameters predict radiation pneumonitis after induction chemoradiotherapy followed by surgery for non-small cell lung cancer: a retrospective analysis. BMC Cancer. 2019;19:1144.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yokomise H, Gotoh M, Okamoto T, Yamamoto Y, Ishikawa S, Nakashima T, et al. Induction chemoradiotherapy (carboplatin-taxane and concurrent 50-Gy radiation) for bulky cN2, N3 non-small cell lung cancer. J Thorac Cardiovasc Surg. 2007;133:1179–85.

Article  CAS  PubMed  Google Scholar 

Kanda Y. Investigation of the freely available easy-to-use software “EZR” for medical statistics. Bone Marrow Transpl. 2013;48:452–8.

Article  CAS  Google Scholar 

Soh J, Sugimoto S, Namba K, Miura A, Shiotani T, Yamamoto H, et al. Chronic lung injury after trimodality therapy for locally advanced non-small cell lung cancer. Ann Thorac Surg. 2021;112:279–88.

Article  PubMed  Google Scholar 

Sugimoto S, Soh J, Suzawa K, Miyoshi K, Otani S, Yamamoto H, et al. Pulmonary aspergillosis as a late complication after surgery for locally advanced non-small cell lung cancer treated with induction chemoradiotherapy. Surg Today. 2020;50:863–71.

Article  CAS  PubMed  Google Scholar 

Antonia SJ, Villegas A, Daniel D, Vicente D, Murakami S, Hui R, et al. Durvalumab after chemoradiotherapy in stage III non-small-cell lung cancer. N Engl J Med. 2017;377:1919–29.

Article  CAS  PubMed  Google Scholar 

Forde PM, Spicer J, Lu S, Provencio M, Mitsudomi T, Awad MM, et al. Neoadjuvant nivolumab plus chemotherapy in resectable lung cancer. N Engl J Med. 2022;386:1973–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rodrigues G, Lock M, D’Souza D, Yu E, Van Dyk J. Prediction of radiation pneumonitis by dose - volume histogram parameters in lung cancer–a systematic review. Radiother Oncol. 2004;71:127–38.

Article  PubMed  Google Scholar 

Palma DA, Senan S, Tsujino K, Barriger RB, Rengan R, Moreno M, et al. Predicting radiation pneumonitis after chemoradiation therapy for lung cancer: an international individual patient data meta-analysis. Int J Radiat Oncol Biol Phys. 2013;85:444–50.

Article  PubMed  Google Scholar 

Takahashi S, Go T, Kasai Y, Yokomise H, Shibata T. Relationship between dose–volume parameters and pulmonary complications after neoadjuvant chemoradiotherapy followed by surgery for lung cancer. Strahlenther Onkol. 2016;192:658–67.

Article  PubMed  Google Scholar 

Hanania AN, Mainwaring W, Ghebre YT, Hanania NA, Ludwig M. Radiation-induced lung injury: assessment and management. Chest. 2019;156:150–62.

Article  PubMed  PubMed Central