Harnessing ferroptosis for enhanced sarcoma treatment: mechanisms, progress and prospects

Beird HC, Bielack SS, Flanagan AM, Gill J, Heymann D, Janeway KA, Livingston JA, Roberts RD, Strauss SJ, Gorlick R. Osteosarcoma. Nat Rev Dis Primers. 2022;8:77.

Article  PubMed  Google Scholar 

Fathizadeh H, Mirzaei H, Asemi Z. Melatonin: an anti-tumor agent for osteosarcoma. Cancer Cell Int. 2019;19:319.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gamboa AC, Gronchi A, Cardona K. Soft-tissue sarcoma in adults: an update on the current state of histiotype-specific management in an era of personalized medicine. CA Cancer J Clin. 2020;70:200–29.

Article  PubMed  Google Scholar 

Meyer M, Seetharam M. First-line therapy for metastatic soft tissue sarcoma. Curr Treat Options Oncol. 2019;20:6.

Article  PubMed  Google Scholar 

Meltzer PS, Helman LJ. New Horizons in the Treatment of osteosarcoma. N Engl J Med. 2021;385:2066–76.

Article  CAS  PubMed  Google Scholar 

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hirschhorn T, Stockwell BR. The development of the concept of ferroptosis. Free Radic Biol Med. 2019;133:130–43.

Article  CAS  PubMed  Google Scholar 

Li J, Cao F, Yin HL, Huang ZJ, Lin ZT, Mao N, Sun B, Wang G. Ferroptosis: past, present and future. Cell Death Dis. 2020;11:88.

Article  PubMed  PubMed Central  Google Scholar 

Lei T, Qian H, Lei P, Hu Y. Ferroptosis-related gene signature associates with immunity and predicts prognosis accurately in patients with osteosarcoma. Cancer Sci. 2021;112:4785–98.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo J, Xu B, Han Q, Zhou H, Xia Y, Gong C, Dai X, Li Z, Wu G. Ferroptosis: A Novel Anti-tumor Action for Cisplatin. Cancer Res Treat. 2018;50:445–60.

Article  CAS  PubMed  Google Scholar 

Lin H, Chen X, Zhang C, Yang T, Deng Z, Song Y, Huang L, Li F, Li Q, Lin S, Jin D. EF24 induces ferroptosis in osteosarcoma cells through HMOX1. Biomed Pharmacother. 2021;136: 111202.

Article  CAS  PubMed  Google Scholar 

Tang D, Chen X, Kang R, Kroemer G. Ferroptosis: molecular mechanisms and health implications. Cell Res. 2021;31:107–25.

Article  CAS  PubMed  Google Scholar 

Morales M, Xue X. Targeting iron metabolism in cancer therapy. Theranostics. 2021;11:8412–29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Egyed A, Saltman P. Iron is maintained as Fe(II) under aerobic conditions in erythroid cells. Biol Trace Elem Res. 1984;6:357–64.

Article  CAS  PubMed  Google Scholar 

Breuer W, Epsztejn S, Cabantchik ZI. Iron acquired from transferrin by K562 cells is delivered into a cytoplasmic pool of chelatable iron(II). J Biol Chem. 1995;270:24209–15.

Article  CAS  PubMed  Google Scholar 

García-Yébenes I, Sobrado M, Moraga A, Zarruk JG, Romera VG, Pradillo JM. Perez de la Ossa N, Moro MA, Dávalos A, Lizasoain I: iron overload, measured as serum ferritin, increases brain damage induced by focal ischemia and early reperfusion. Neurochem Int. 2012;61:1364–9.

Article  PubMed  Google Scholar 

Stoyanovsky DA, Tyurina YY, Shrivastava I, Bahar I, Tyurin VA, Protchenko O, Jadhav S, Bolevich SB, Kozlov AV, Vladimirov YA, et al. Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction? Free Radic Biol Med. 2019;133:153–61.

Article  CAS  PubMed  Google Scholar 

Hassannia B, Vandenabeele P, Vanden Berghe T. Targeting ferroptosis to iron out cancer. Cancer Cell. 2019;35:830–49.

Article  CAS  PubMed  Google Scholar 

Gaschler MM, Stockwell BR. Lipid peroxidation in cell death. Biochem Biophys Res Commun. 2017;482:419–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shah R, Shchepinov MS, Pratt DA. Resolving the role of lipoxygenases in the initiation and execution of ferroptosis. ACS Cent Sci. 2018;4:387–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol. 2017;13:81–90.

Article  CAS  PubMed  Google Scholar 

Li QQ, Li Q, Jia JN, Liu ZQ, Zhou HH, Mao XY. 12/15 lipoxygenase: a crucial enzyme in diverse types of cell death. Neurochem Int. 2018;118:34–41.

Article  CAS  PubMed  Google Scholar 

NaveenKumar SK, Hemshekhar M, Kemparaju K, Girish KS. Hemin-induced platelet activation and ferroptosis is mediated through ROS-driven proteasomal activity and inflammasome activation: Protection by Melatonin. Biochim Biophys Acta Mol Basis Dis. 2019;1865:2303–16.

Article  CAS  PubMed  Google Scholar 

Zou Y, Li H, Graham ET, Deik AA, Eaton JK, Wang W, Sandoval-Gomez G, Clish CB, Doench JG, Schreiber SL. Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis. Nat Chem Biol. 2020;16:302–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma S, Henson ES, Chen Y, Gibson SB. Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells. Cell Death Dis. 2016;7: e2307.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao M, Monian P, Quadri N, Ramasamy R, Jiang X. Glutaminolysis and Transferrin Regulate Ferroptosis. Mol Cell. 2015;59:298–308.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang WS, Stockwell BR. Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem Biol. 2008;15:234–45.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Manz DH, Blanchette NL, Paul BT, Torti FM, Torti SV. Iron and cancer: recent insights. Ann N Y Acad Sci. 2016;1368:149–61.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Wang YQ, Chang SY, Wu Q, Gou YJ, Jia L, Cui YM, Yu P, Shi ZH, Wu WS, Gao G, Chang YZ. The protective role of mitochondrial ferritin on erastin-induced ferroptosis. Front Aging Neurosci. 2016;8:308.

Article  PubMed  PubMed Central  Google Scholar 

Hou W, Xie Y, Song X, Sun X, Lotze MT, Zeh HJ 3rd, Kang R, Tang D. Autophagy promotes ferroptosis by degradation of ferritin. Autophagy. 2016;12:1425–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao M, Monian P, Pan Q, Zhang W, Xiang J, Jiang X. Ferroptosis is an autophagic cell death process. Cell Res. 2016;26:1021–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brown CW, Amante JJ, Chhoy P, Elaimy AL, Liu H, Zhu LJ, Baer CE, Dixon SJ, Mercurio AM. Prominin2 drives ferroptosis resistance by stimulating iron export. Dev Cell. 2019;51:575-586.e574.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Geng N, Shi BJ, Li SL, Zhong ZY, Li YC, Xua WL, Zhou H, Cai JH. Knockdown of ferroportin accelerates erastin-induced ferroptosis in neuroblastoma cells. Eur Rev Med Pharmacol Sci. 2018;22:3826–36.

CAS  PubMed  Google Scholar 

Chen X, Li J, Kang R, Klionsky DJ, Tang D. Ferroptosis: machinery and regulation. Autophagy. 2021;17:2054–81.

Article  CAS  PubMed  Google Scholar 

Seibt TM, Proneth B, Conrad M. Role of GPX4 in ferroptosis and its pharmacological implication. Free Radic Biol Med. 2019;133:144–52.

Article  CAS  PubMed  Google Scholar 

Comments (0)

No login
gif