Bicuspid aortic valve (BAV) is the most common congenital heart malformation in adults but can also cause childhood-onset complications. In multicenter study, we found that adults who experience significant complications of BAV disease before age 30 are distinguished from the majority of BAV cases that manifest after age 50 by a relatively severe clinical course, with higher rates of surgical interventions, more frequent second interventions, and a greater burden of congenital heart malformations. These observations highlight the need for prompt recognition, regular lifelong surveillance, and targeted interventions to address the significant health burdens of patients with early onset BAV complications.

The authors have declared no competing interest.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549564/

This work was supported in part by R01HL137028 (S.K.P.) and R01HL114823 (S.C.B.).

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The study protocol was approved by the Committee for the Protection of Human Subjects at the University of Texas Health Science Center at Houston (HSC-MS-11-0185). All participants signed a written consent form, and study procedures were conducted in compliance with the ethical standards of the relevant national guidelines on human experimentation (HHS regulations 45 CFR part 46) and with the Helsinki Declaration of 1975, as revised in 2008. IRB of the University of Texas Health Science Center at Houston (HSC-MS-11-0185) gave ethical approval for this work.

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