Authors Y Huang, CC Wang and AI Rosenbaum performed work within this manuscript while employed by AstraZeneca. The authors' employment and stock investments in AstraZeneca do not affect the authenticity and objectivity of the experimental result detailed in this manuscript. Authors MS Woolf, SM Naser, AM Wheeler, WR Mylott and E Ma performed work within this manuscript while employed by PPD, a part of Thermo Fisher Scientific. The authors' employment and stock investments in Thermo Fisher Scientific do not affect the authenticity and objectivity of the experimental result detailed in this manuscript. Responsibility for opinions, conclusions and data interpretation lies with the authors and should not be interpreted as representing the official views or policies of the Department of Defense or the US government. The authors have no other competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript apart from those disclosed.