Posner J, Polanczyk GV, Sonuga-Barke E (2020) Attention-deficit hyperactivity disorder. The Lancet 395(10222):450–462

Article  Google Scholar 

Brondum J (2007) Environmental exposures and ADHD. Environ Health Perspect 115(8):A398–A398

Article  PubMed  PubMed Central  Google Scholar 

Froehlich TE, Anixt JS, Loe IM, Chirdkiatgumchai V, Kuan L, Gilman RC (2011) Update on environmental risk factors for attention-deficit/hyperactivity disorder. Curr Psychiatr Rep 13(5):333–344

Danielson ML, Bitsko RH, Ghandour RM, Holbrook JR, Kogan MD, Blumberg SJ (2018) Prevalence of parent-reported ADHD diagnosis and associated treatment among U.S. Children and adolescents, 2016. J Clin Child Adolesc Psychol 47(2):199–212

Lozano R, Fullman N, Mumford JE, Knight M, Barthelemy CM, Abbafati C, Abbastabar H, Abd-Allah F, Abdollahi M, Abedi A, Abolhassani H, Abosetugn AE, Abreu LG, Abrigo MRM, Abu Haimed AK, Abushouk AI, Adabi M, Adebayo OM, Adekanmbi V et al (2020) Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet 396(10258):1250–1284

Article  Google Scholar 

Franke B, Michelini G, Asherson P, Banaschewski T, Bilbow A, Buitelaar JK, Cormand B, Faraone SV, Ginsberg Y, Haavik J, Kuntsi J, Larsson H, Lesch K-P, Ramos-Quiroga JA, Réthelyi JM, Ribases M, Reif A (2018) Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan. Eur Neuropsychopharmacol 28(10):1059–1088

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dórea JG (2020) Neurotoxic effects of combined exposures to aluminum and mercury in early life (infancy). Environ Res 188:109734

Article  PubMed  Google Scholar 

Gade M, Comfort N, Re DB (2021) Sex-specific neurotoxic effects of heavy metal pollutants: epidemiological, experimental evidence and candidate mechanisms. Environ Res 201:111558

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kothapalli CR (2021) Differential impact of heavy metals on neurotoxicity during development and in aging central nervous system. Current Opinion in Toxicology 26:33–38

Article  CAS  Google Scholar 

Rocha A, Trujillo KA (2019) Neurotoxicity of low-level lead exposure: History, mechanisms of action, and behavioral effects in humans and preclinical models. Neurotoxicology 73:58–80

Article  CAS  PubMed  PubMed Central  Google Scholar 

Santos-Lima C, de Carvalho CF, Farréol Bah HA, Menezes-Filho JA (2022) The implications of exposure to neurotoxic metals for cognitive development of children and adolescents. In Alves MV, Ekuni R, Hermida MJ, Valle-Lisboa J (eds) Cognitive sciences and education in non-WEIRD populations: a Latin American perspective. Springer, pp 135–150

Attar T (2020) A mini-review on importance and role of trace elements in the human organism. Chem Rev Lett 3(3):117–130

CAS  Google Scholar 

Daneshparvar M, Mostafavi S-A, Zare Jeddi M, Yunesian M, Mesdaghinia A, Mahvi AH, Akhondzadeh S (2016) The role of lead exposure on attention-deficit/ hyperactivity disorder in children: a systematic review. Iran J Psychiatr 11(1):1–14

Nayak S, Sahu S, Patra S, John J (2021) Assessment of copper and zinc levels in hair and urine of children with attention deficit hyperactivity disorder: a case-control study in eastern India. Cureus 13(12):e20692

PubMed  PubMed Central  Google Scholar 

Skalny AV, Mazaletskaya AL, Ajsuvakova OP, Bjørklund G, Skalnaya MG, Chao JC-J, Chernova LN, Shakieva RA, Kopylov PYu, Skalny AA, Tinkov AA (2020) Serum zinc, copper, zinc-to-copper ratio, and other essential elements and minerals in children with attention deficit/hyperactivity disorder (ADHD). J Trace Elem Med Biol 58:126445

Article  CAS  PubMed  Google Scholar 

Viktorinova A, Ursinyova M, Trebaticka J, Uhnakova I, Durackova Z, Masanova V (2016) Changed plasma levels of zinc and copper to zinc ratio and their possible associations with parent- and teacher-rated symptoms in children with attention-deficit hyperactivity disorder. Biol Trace Elem Res 169(1):1–7

Article  CAS  PubMed  Google Scholar 

Villagomez A, Ramtekkar U (2014) Iron, Magnesium, vitamin D, and zinc deficiencies in children presenting with symptoms of attention-deficit/hyperactivity disorder. Children (Basel, Switzerland) 1(3):261–279

PubMed  Google Scholar 

Yang R, Zhang Y, Gao W, Lin N, Li R, Zhao Z (2019) Blood levels of trace elements in children with attention-deficit hyperactivity disorder: results from a case-control study. Biol Trace Elem Res 187(2):376–382

Article  CAS  PubMed  Google Scholar 

Bales CW, Freeland-Graves JH, Askey S, Behmardi F, Pobocik RS, Fickel JJ, Greenlee P (1990) Zinc, magnesium, copper, and protein concentrations in human saliva: age- and sex-related differences. Am J Clin Nutr 51(3):462–469

Article  CAS  PubMed  Google Scholar 

Barbosa F, Corrêa Rodrigues MH, Buzalaf MR, Krug FJ, Gerlach RF, Tanus-Santos JE (2006) Evaluation of the use of salivary lead levels as a surrogate of blood lead or plasma lead levels in lead exposed subjects. Arch Toxicol 80(10):633–637

Article  CAS  PubMed  Google Scholar 

Wang D, Du X, Zheng W (2008) Alteration of saliva and serum concentrations of manganese, copper, zinc, cadmium and lead among career welders. Toxicol Lett 176(1):40–47

Article  CAS  PubMed  Google Scholar 

Barry MJ, Almotawah F, Pani SC, Ingle NA (2020) A comparison of salivary mercury levels in children with attention deficit/hyperactivity disorder when compared to age-matched controls: a case-control observational study. J Contemp Dent Pract 21(2):129–132

Article  PubMed  Google Scholar 

Davis E, Bakulski KM, Goodrich JM, Peterson KE, Marazita ML, Foxman B (2020) Low levels of salivary metals, oral microbiome composition and dental decay. Sci Rep 10(1):14640

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vernon-Feagans L, Cox M. Family Life Project Key Investigators (2013) The family life project: an epidemiological and developmental study of young children living in poor rural communities. Monogr Soc Res Child Dev 78(5):vii–vii

Granger DA, Fortunato CK, Beltzer EK, Virag M, Bright MA, Out D (2012) Focus on methodology: salivary bioscience and research on adolescence: an integrated perspective. J Adolesc 35(4):1081–1095

Article  PubMed  Google Scholar 

Nowak S, Künnemeyer J, Terborg L, Trümpler S, Günsel A, Wiesmüller GA, Karst U, Buscher W (2015) Analysis of whole blood samples with low gas flow inductively coupled plasma-optical emission spectrometry. Anal Bioanal Chem 407(3):1023–1026

Article  CAS  PubMed  Google Scholar 

Li Y, Cha C, Lv X, Liu J, He J, Pang Q, Meng L, Kuang H, Fan R (2020) Association between 10 urinary heavy metal exposure and attention deficit hyperactivity disorder for children. Environ Sci Pollut Res 27(25):31233–31242

Article  CAS  Google Scholar 

Elbaz F, Zahra S, Hanafy H (2017) Magnesium, zinc and copper estimation in children with attention deficit hyperactivity disorder (ADHD). Egypt J Med Hum Genet 18(2):153–163

Article  Google Scholar 

Yu WR, Jiang H, Wang J, Xie JX (2008) Copper (Cu2+) induces degeneration of dopaminergic neurons in the nigrostriatal system of rats. Neurosci Bull 24(2):73–78

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yousef S, Adem A, Zoubeidi T, Kosanovic M, Mabrouk AA, Eapen V (2011) Attention deficit hyperactivity disorder and environmental toxic metal exposure in the United Arab Emirates. J Trop Pediatr 57(6):457–460

Article  PubMed  Google Scholar 

Bouchard M, Laforest F, Vandelac L, Bellinger D, Mergler D (2007) Hair manganese and hyperactive behaviors: pilot study of school-age children exposed through Tap Water. Environ Health Perspect 115(1):122–127

Article  CAS  PubMed  Google Scholar 

Shih J-H, Zeng B-Y, Lin P-Y, Chen T-Y, Chen Y-W, Wu C-K, Tseng P-T, Wu M-K (2018) Association between peripheral manganese levels and attention-deficit/hyperactivity disorder: a preliminary meta-analysis. Neuropsychiatr Dis Treat 14:1831–1842

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schullehner J, Thygesen M, Kristiansen SM, Hansen B, Pedersen CB, Dalsgaard S (2019) Exposure to manganese in drinking water during childhood and association with attention-deficit hyperactivity disorder: a nationwide cohort study. Environ Health Perspect 128(9):097004

Oulhote Y, Mergler D, Bouchard MF (2014) Sex- and age-differences in blood manganese levels in the U.S. general population: national health and nutrition examination survey 2011–2012. Environ Health 13(1):87

Geron M, Cowell W, Amarasiriwardena C, Andra SS, Carroll K, Kloog I, Wright RO, Wright RJ (2022) Racial/ethnic and neighborhood disparities in metals exposure during pregnancy in the Northeastern United States. Sci Total Environ 820:153249

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bouchard MF, Surette C, Cormier P, Foucher D (2018) Low level exposure to manganese from drinking water and cognition in school-age children. Neurotoxicology 64:110–117

Article  CAS  PubMed  Google Scholar 

Ntihabose R, Surette C, Foucher D, Clarisse O, Bouchard MF (2018) Assessment of saliva, hair and toenails as biomarkers of low level exposure to manganese from drinking water in children. Neurotoxicology 64:126–133

Article  CAS  PubMed  Google Scholar 

Hong S-B, Kim J-W, Choi B-S, Hong Y-C, Park E-J, Shin M-S, Kim B-N, Yoo H-J, Cho I-H, Bhang S-Y, Cho S-C (2014) Blood manganese levels in relation to comorbid behavioral and emotional problems in children with attention-deficit/hyperactivity disorder. Psychiatry Res 220(1–2):418–425

Article  CAS  PubMed  Google Scholar 

Kocyigit A, Erel O, Gur S (2001) Effects of tobacco smoking on plasma selenium, zinc, copper and iron concentrations and related antioxidative enzyme activities. Clin Biochem 34(8):629–633

Article  CAS  PubMed  Google Scholar 

Omar S, Abdennebi M, Ben Mami F, Ghanem A, Azzabi S, Hedhili A, Zouari B, Achour A, Guemira F (2001) Serum copper levels in obesity: a study of 32 cases. Tunis Med 79(6–7):370–373

CAS  PubMed  Google Scholar 

Gatzke-Kopp LM, Riis JL, Ahmadi H, Piccerillo HL, Granger DA, Blair CB, Thomas EA (2023) Environmental tobacco smoke exposure is associated with increased levels of metals in children’s saliva. J Eposure Sci Environ Epidemiol 33(6):903–910

Article  CAS  Google Scholar 

Beery SH, Quay HC, Pelham WE (2017) Differential response to methylphenidate in inattentive and combined subtype ADHD. J Att