Ashburn, T. T., & Thor, K. B. (2004). Drug repositioning: Identifying and developing new uses for existing drugs. Nature Reviews Drug Discovery, 3(8), 673–683. https://doi.org/10.1038/nrd1468

Article  CAS  PubMed  Google Scholar 

Nosengo, N. (2016). Can you teach old drugs new tricks? Nature, 534(7607), 7607. https://doi.org/10.1038/534314a

Article  Google Scholar 

Smith, S. B., Dampier, W., Tozeren, A., Brown, J. R., & Magid-Slav, M. (2012). Identification of common biological pathways and drug targets across multiple respiratory viruses based on human host gene expression analysis. PLoS ONE, 7(3), e33174. https://doi.org/10.1371/journal.pone.0033174

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim, Y., & He, Y.-Y. (2014). Ultraviolet radiation-induced non-melanoma skin cancer: Regulation of DNA damage repair and inflammation. Genes & Diseases, 1(2), 188–198. https://doi.org/10.1016/j.gendis.2014.08.005

Article  Google Scholar 

Birch-Johansen, F., Jensen, A., Mortensen, L., Olesen, A. B., & Kjær, S. K. (2010). Trends in the incidence of nonmelanoma skin cancer in Denmark 1978–2007: Rapid incidence increase among young Danish women. International Journal of Cancer, 127(9), 2190–2198. https://doi.org/10.1002/ijc.25411

Article  CAS  PubMed  Google Scholar 

Tokez, S., Hollestein, L., Louwman, M., Nijsten, T., & Wakkee, M. (2020). Incidence of multiple vs first cutaneous squamous cell carcinoma on a nationwide scale and estimation of future incidences of cutaneous squamous cell carcinoma. JAMA Dermatology, 156(12), 1–7. https://doi.org/10.1001/jamadermatol.2020.3677

Article  PubMed Central  Google Scholar 

Guo, A., Liu, X., Li, H., Cheng, W., & Song, Y. (2023). The global, regional, national burden of cutaneous squamous cell carcinoma (1990–2019) and predictions to 2035. European Journal of Cancer Care, 2023, e5484597. https://doi.org/10.1155/2023/5484597

Article  Google Scholar 

Holman, D. M., Berkowitz, Z., Guy, G. P. J., Hawkins, N. A., Saraiya, M., & Watson, M. (2015). Patterns of sunscreen use on the face and other exposed skin among US adults. Journal of the American Academy of Dermatology, 73(1), 83-92.e1. https://doi.org/10.1016/j.jaad.2015.02.1112

Article  PubMed  PubMed Central  Google Scholar 

Pihl, C., Togsverd-Bo, K., Andersen, F., Haedersdal, M., Bjerring, P., & Lerche, C. M. (2021). Keratinocyte carcinoma and photoprevention: The protective actions of repurposed pharmaceuticals, phytochemicals and vitamins. Cancers, 13(15), 3684. https://doi.org/10.3390/cancers13153684

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu, C., Qiang, L., Han, W., Ming, M., Viollet, B., & He, Y.-Y. (2013). Role of AMPK in UVB-induced DNA damage repair and growth control. Oncogene, 32(21), 2682–2689. https://doi.org/10.1038/onc.2012.279

Article  CAS  PubMed  Google Scholar 

Zhou, Q., Kim, S. H., Pérez-Lorenzo, R., Liu, C., Huang, M., Dotto, G. P., Zheng, B., & Wu, X. (2021). Phenformin promotes keratinocyte differentiation via the calcineurin/NFAT pathway. The Journal of Investigative Dermatology, 141(1), 152–163. https://doi.org/10.1016/j.jid.2020.05.114

Article  CAS  PubMed  Google Scholar 

Huang, K. M., Liang, S., Yeung, S., Oiyemhonlan, E., Cleveland, K. H., Parsa, C., Orlando, R., Meyskens, F. L., Jr., Andresen, B. T., & Huang, Y. (2017). Topically applied carvedilol attenuates solar ultraviolet radiation induced skin carcinogenesis. Cancer Prevention Research, 10(10), 598–606. https://doi.org/10.1158/1940-6207.CAPR-17-0132

Article  CAS  PubMed  Google Scholar 

Abdullah Shamim, M., Yeung, S., Shahid, A., Chen, M., Wang, J., Desai, P., Parsa, C., Orlando, R., Meyskens, F. L., Jr., Kelly, K. M., Andresen, B. T., & Huang, Y. (2022). Topical carvedilol delivery prevents UV-induced skin cancer with negligible systemic absorption. International Journal of Pharmaceutics, 611, 121302. https://doi.org/10.1016/j.ijpharm.2021.121302

Article  CAS  PubMed  Google Scholar 

Revive Therapeutics, Ltd. (2023). Multi-center, randomized, double-blind, placebo-controlled study of bucillamine in patients with mild-moderate COVID-19 (clinical trial registration NCT04504734). clinicaltrials.gov. https://clinicaltrials.gov/study/NCT04504734

Anwar, A., Gu, M., Brady, S., Qamar, L., Behbakht, K., Shellman, Y. G., Agarwal, R., Norris, D. A., Horwitz, L. D., & Fujita, M. (2008). Photoprotective effects of bucillamine against UV-induced damage in an SKH-1 hairless mouse model†. Photochemistry and Photobiology, 84(2), 477–483. https://doi.org/10.1111/j.1751-1097.2007.00288.x

Article  CAS  PubMed  Google Scholar 

Anwar, A., Anwar, H., Yamauchi, T., Tseng, R., Agarwal, R., Horwitz, L. D., Zhai, Z., & Fujita, M. (2020). Bucillamine inhibits UVB-induced MAPK activation and apoptosis in human HaCaT keratinocytes and SKH-1 hairless mouse skin. Photochemistry and Photobiology, 96(4), 870–876. https://doi.org/10.1111/php.13228

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pihl, C., Bendtsen, K. M. S., Jensen, H. E., Andersen, F., Bjerring, P., Haedersdal, M., & Lerche, C. M. (2023). Oral phytochemicals as photoprotectants in UVR exposed hairless mice: A study of hesperidin methyl chalcone, phloroglucinol, and syringic acid. Journal of Photochemistry and Photobiology B: Biology, 246, 112760. https://doi.org/10.1016/j.jphotobiol.2023.112760

Article  CAS  PubMed  Google Scholar 

Nair, A. B., & Jacob, S. (2016). A simple practice guide for dose conversion between animals and human. Journal of Basic and Clinical Pharmacy, 7(2), 27–31. https://doi.org/10.4103/0976-0105.177703

Article  PubMed  PubMed Central  Google Scholar 

R Core Team. (2021). R: A language and environment for statistical computing. (3.6.0) [Software]. https://www.R-project.org/

Kassambara, A., Kosinski, M., Biecek, P., Marcin, K., & Przemyslaw, B. (2021). survminer: Drawing survival curves using “ggplot2”. (0.4.9) [Software]. https://CRAN.R-project.org/package=survminer

Siddiqui, S., Deshmukh, A. J., Mudaliar, P., Nalawade, A. J., Iyer, D., & Aich, J. (2022). Drug repurposing: Re-inventing therapies for cancer without re-entering the development pipeline—A review. Journal of the Egyptian National Cancer Institute, 34(1), 33. https://doi.org/10.1186/s43046-022-00137-0

Article  PubMed  PubMed Central  Google Scholar 

Kapetanovic, I. M., Krishnaraj, R., Martin-Jimenez, T., Yuan, L., van Breemen, R. B., & Lyubimov, A. (2006). Effects of oral dosing paradigms (gavage versus diet) on pharmacokinetics and pharmacodynamics. Chemico-Biological Interactions, 164(1), 68–75. https://doi.org/10.1016/j.cbi.2006.08.019

Article  CAS  PubMed  Google Scholar 

Farmer, R. E., Ford, D., Mathur, R., Chaturvedi, N., Kaplan, R., Smeeth, L., & Bhaskaran, K. (2019). Metformin use and risk of cancer in patients with type 2 diabetes: A cohort study of primary care records using inverse probability weighting of marginal structural models. International Journal of Epidemiology, 48(2), 527–537. https://doi.org/10.1093/ije/dyz005

Article  PubMed  PubMed Central  Google Scholar 

Ravishankar, A., Zhang, T., Lindgren, B. R., Farah, R. S., Dong, Z., & Goldfarb, N. I. (2020). The effect of metformin on the risk of recurrent nonmelanoma skin cancers. International Journal of Dermatology, 59(8), e303–e305. https://doi.org/10.1111/ijd.14829

Article  PubMed  PubMed Central  Google Scholar 

von Möllendorff, E., Reiff, K., & Neugebauer, G. (1987). Pharmacokinetics and bioavailability of carvedilol, a vasodilating beta-blocker. European Journal of Clinical Pharmacology, 33(5), 511–513. https://doi.org/10.1007/BF00544245

Article  Google Scholar 

Bailey, C. J. (2017). Metformin: Historical overview. Diabetologia, 60(9), 1566–1576. https://doi.org/10.1007/s00125-017-4318-z

Article  CAS  PubMed  Google Scholar 

Appleyard, M. V. C. L., Murray, K. E., Coates, P. J., Wullschleger, S., Bray, S. E., Kernohan, N. M., Fleming, S., Alessi, D. R., & Thompson, A. M. (2012). Phenformin as prophylaxis and therapy in breast cancer xenografts. British Journal of Cancer, 106(6), 1117–1122. https://doi.org/10.1038/bjc.2012.56

Article  CAS  PubMed  PubMed Central  Google Scholar 

Di Magno, L., Manni, S., Di Pastena, F., Coni, S., Macone, A., Cairoli, S., Sambucci, M., Infante, P., Moretti, M., Petroni, M., Nicoletti, C., Capalbo, C., De Smaele, E., Di Marcotullio, L., Giannini, G., Battistini, L., Goffredo, B. M., Iorio, E., Agostinelli, E., … Canettieri, G. (2020). Phenformin inhibits Hedgehog-dependent tumor growth through a complex I—Independent redox/corepressor module. Cell Reports, 30(6), 1735-1752.e7. https://doi.org/10.1016/j.celrep.2020.01.024

Article  CAS  PubMed  Google Scholar 

D’Agostini, F., Balansky, R. M., Camoirano, A., & De Flora, S. (2005). Modulation of light-induced skin tumors by N-acetylcysteine and/or ascorbic acid in hairless mice. Carcinogenesis, 26(3), 657–664. https://doi.org/10.1093/carcin/bgi008

Article  PubMed  Google Scholar 

Yan, M., Liu, Z., Yang, H., Li, C., Chen, H., Liu, Y., Zhao, M., & Zhu, Y. (2016). Luteolin decreases the UVA-induced autophagy of human skin fibroblasts by scavenging ROS. Molecular Medicine Reports, 14(3), 1986–1992. https://doi.org/10.3892/mmr.2016.5517

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oh, M. C., Piao, M. J., Fernando, P. M. D. J., Han, X., Hewage, S. R. K. M., Park, J. E., Ko, M. S., Jung, U., Kim, I. G., & Hyun, J. W. (2016). Baicalein protects human skin cells against ultraviolet B-induced oxidative stress. Biomolecules & Therapeutics, 24(6), 616. https://doi.org/10.4062/biomolther.2016.022

Article  CAS  Google Scholar