Impacts of a 12-week aerobic, resistance, and combined exercise training on serum FAM19A5, glucose homeostasis, and novel cardiovascular risk factors among adults with obesity

World Health Organization. Obesity and overweight. Available online: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. Accessed on 25 January 2022.

Abdelaal M, le Roux CW, Docherty NG. Morbidity and mortality associated with obesity. Ann Transl Med. 2017;5(7):161.

Article  PubMed  PubMed Central  Google Scholar 

Nakamura K, Fuster JJ, Walsh K. Adipokines: a link between obesity and cardiovascular disease. J Cardiol. 2014;63(4):250–9.

Article  PubMed  Google Scholar 

Matsuzawa Y. Therapy insight: adipocytokines in metabolic syndrome and related cardiovascular disease. Nat Clin Pract Cardiovasc Med. 2006;3(1):35–42.

Article  CAS  PubMed  Google Scholar 

Wang Y, Chen D, Zhang Y, Wang P, Zheng C, et al. Novel adipokine, FAM19A5, inhibits neointima formation after injury through sphingosine-1-phosphate receptor 2. Circulation. 2018;138(1):48–63.

Article  CAS  PubMed  Google Scholar 

Lee Y-B, Hwang H-J, Kim JA, Hwang SY, Roh E, et al. Association of serum FAM19A5 with metabolic and vascular risk factors in human subjects with or without type 2 diabetes. Diab Vasc Dis Res. 2019;16(6):530–8.

Article  CAS  PubMed  Google Scholar 

Ali Yari F, Shabani P, Karami S, Sarmadi N, Poustchi H, et al. Circulating levels of FAM19A5 are inversely associated with subclinical atherosclerosis in non-alcoholic fatty liver disease. BMC Endocr Disord. 2021;21(1):153.

Article  Google Scholar 

Wang W, Li T, Wang X, Yuan W, Cheng Y, et al. FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and is able to promote the migration and phagocytosis of macrophages. Cell Mol Immunol. 2015;12(5):615–24.

Article  PubMed  Google Scholar 

Chen L, Chen R, Wang H, Liang F. Mechanisms linking inflammation to insulin resistance. Int J Endocrinol. 2015;2015:508409.

Cefalu WT. Inflammation, insulin resistance, and type 2 diabetes: back to the future? Diabetes. 2009;58(2):307–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khan UI, Wang D, Sowers MR, Mancuso P, Everson-Rose SA, et al. Race–ethnic differences in adipokine levels: the Study of Women’s Health Across the Nation (SWAN). Metabolism. 2012;61(9):1261–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hosseinpanah F, Barzin M, Mirbolouk M, Abtahi H, Cheraghi L, et al. Lipid accumulation product and incident cardiovascular events in a normal weight population: Tehran Lipid and Glucose Study. Eur J Prev Cardiol. 2016;23(2):187–93.

Article  PubMed  Google Scholar 

Han L, Fu K-L, Zhao J, Wang Z-H, Tang M-X, et al. Visceral adiposity index score indicated the severity of coronary heart disease in Chinese adults. Diabetol Metab Syndr. 2014;6(1):1–6.

Article  Google Scholar 

Lee EY, Yang HK, Lee J, Kang B, Yang Y, et al. Triglyceride glucose index, a marker of insulin resistance, is associated with coronary artery stenosis in asymptomatic subjects with type 2 diabetes. Lipids Health Dis. 2016;15(1):1–7.

Article  Google Scholar 

Amato MC, Giordano C, Galia M, Criscimanna A, Vitabile S, et al. Visceral adiposity index: a reliable indicator of visceral fat function associated with cardiometabolic risk. Diabetes Care. 2010;33(4):920–2.

Article  PubMed  PubMed Central  Google Scholar 

Xia C, Li R, Zhang S, Gong L, Ren W, et al. Lipid accumulation product is a powerful index for recognizing insulin resistance in non-diabetic individuals. Eur J Clin Nutr. 2012;66(9):1035–8.

Article  CAS  PubMed  Google Scholar 

Kim TJ, Kim HJ, Kim YB, Lee JY, Lee HS, et al. Comparison of surrogate markers as measures of uncomplicated insulin resistance in Korean adults. Korean J Fam Med. 2016;37(3):188–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McAuley KA, Williams SM, Mann JI, Walker RJ, Lewis-Barned NJ, et al. Diagnosing insulin resistance in the general population. Diabetes Care. 2001;24(3):460–4.

Article  CAS  PubMed  Google Scholar 

Straczkowski M, Stepien A, Kowalska I, Kinalska I. Comparison of simple indices of insulin sensitivity using the euglycemic hyperinsulinemic clamp technique. Medical science monitor. Int Med J Exp Clin Res. 2004;10(8):CR480-4.

CAS  Google Scholar 

Semlitsch T, Stigler FL, Jeitler K, Horvath K, Siebenhofer A. Management of overweight and obesity in primary care—a systematic overview of international evidence-based guidelines. Obes Rev. 2019;20(9):1218–30.

Article  PubMed  PubMed Central  Google Scholar 

Donnelly JE, Blair SN, Jakicic JM, Manore MM, Rankin JW, American College of Sports Medicine Position Stand, et al. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc. 2009;41(2):459–71.

Article  PubMed  Google Scholar 

Oppert JM, Bellicha A, van Baak MA, Battista F, Beaulieu K, et al. Exercise training in the management of overweight and obesity in adults: synthesis of the evidence and recommendations from the European Association for the Study of Obesity Physical Activity Working Group. Obes Rev. 2021;22:e13273.

Article  PubMed  PubMed Central  Google Scholar 

Morze J, Rücker G, Danielewicz A, Przybyłowicz K, Neuenschwander M, et al. Impact of different training modalities on anthropometric outcomes in patients with obesity: a systematic review and network meta-analysis. Obes Rev. 2021;22(7): e13218.

Article  PubMed  PubMed Central  Google Scholar 

Codella R, Ialacqua M, Terruzzi I, Luzi L. May the force be with you: why resistance training is essential for subjects with type 2 diabetes mellitus without complications. Endocrine. 2018;62(1):14–25.

Article  CAS  PubMed  Google Scholar 

Shaw BS, Shaw I. Effect of resistance training on cardiorespiratory endurance and coronary artery disease risk: cardiovascular topics. Cardiovasc J S Afr. 2005;16(5):256–9.

CAS  PubMed  Google Scholar 

Racil G, Zouhal H, Elmontassar W, Abderrahmane AB, De Sousa MV, et al. Plyometric exercise combined with high-intensity interval training improves metabolic abnormalities in young obese females more so than interval training alone. Appl Physiol Nutr Metab. 2016;41(1):103–9.

Article  CAS  PubMed  Google Scholar 

Mohammad Rahimi GR, Bijeh N, Rashidlamir A. Effects of exercise training on serum preptin, undercarboxylated osteocalcin and high molecular weight adiponectin in adults with metabolic syndrome. Exp Physiol. 2020;105(3):449–59.

Article  CAS  PubMed  Google Scholar 

Mancia G, Laurent S, Agabiti-Rosei E, Ambrosioni E, Burnier M, et al. Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. Blood Press. 2009;18(6):308–47.

Article  CAS  PubMed  Google Scholar 

Bruce R. Exercise testing of patients with coronary artery disease. Ann Clin Res. 1971;3:323–32.

CAS  PubMed  Google Scholar 

Balady GJ. ACSM’s guidelines for exercise testing and prescription. Am College Sports Med. 2000.

Brzycki M. Strength testing—predicting a one-rep max from reps-to-fatigue. J Phys Educ Recreat Dance. 1993;64(1):88–90.

Article  Google Scholar 

Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18(6):499–502.

Article  CAS  PubMed  Google Scholar 

Mirmiran P, Bahadoran Z, Azizi F. Lipid accumulation product is associated with insulin resistance, lipid peroxidation, and systemic inflammation in type 2 diabetic patients. Endocrinol Metab (Seoul, Korea). 2014;29(4):443–9.

Article  Google Scholar 

Wakabayashi I, Daimon T. A strong association between lipid accumulation product and diabetes mellitus in Japanese women and men. J Atheroscler Thromb. 2014;21(3):282–8.

Article  PubMed  Google Scholar 

Nascimento-Ferreira MV, Rendo-Urteaga T, Vilanova-Campelo RC, Carvalho HB, de Paz Oliveira G, et al. The lipid accumulation product is a powerful tool to predict metabolic syndrome in undiagnosed Brazilian adults. Clin Nutr. 2017;36(6):1693–700.

Article  CAS  PubMed  Google Scholar 

Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412–9.

Article  CAS  PubMed  Google Scholar 

Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 2000;85(7):2402–10.

Article  CAS  PubMed  Google Scholar 

Lopes WA, Oliveira GHD, Locateli JC, Simões CF. TyG in insulin resistance prediction. Jornal de Pediatria. 2020;96(1):132–3.

Article  PubMed  Google Scholar 

Hopkins W, Marshall S, Batterham A, Hanin J. Progressive statistics for studies in sports medicine and exercise science. Med Sci Sports Exerc. 2009;41(1):3.

Article  PubMed  Google Scholar 

Zarzour A, Kim HW, Weintraub NL. Understanding obesity-related cardiovascular disease: it’s all about balance. Am Heart Assoc. 2018;138:64–6.

Google Scholar 

Mohammad Rahimi GR, AlizaeiYousefabadi H, Niyazi A, Mohammad Rahimi N, Alikhajeh Y. Effects of lifestyle intervention on inflammatory markers and waist circumference in overweight/obese adults with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials. Biol Res Nurs. 2022;24(1):94–105.

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