Gupta R, Woo K, Yi JA. Epidemiology of end-stage kidney disease. Semin Vasc Surg. 2021;34:71–8.

Article  PubMed  PubMed Central  Google Scholar 

United States Renal Data System. 2021 USRDS annual data report: epidemiology of kidney disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. 2021.

Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm LL, et al. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American heart association councils on kidney in cardiovascular disease, high blood pressure research, clinical cardiology, and epidemiology and prevention. Circulation. 2003;108:2154–69.

Article  Google Scholar 

Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl. 2013;3:1–150.

Masson P, Webster AC, Hong M, Turner R, Lindley RI, Craig JC. Chronic kidney disease and the risk of stroke: a systematic review and meta-analysis. Nephrol Dial Transpl. 2015;30:1162–9.

Article  CAS  Google Scholar 

Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, de Jong PE, et al. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet. 2010;375:2073–81.

Article  PubMed  PubMed Central  Google Scholar 

GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2020;395:709–33.

Article  Google Scholar 

Koye DN, Magliano DJ, Nelson RG, Pavkov ME. The global epidemiology of diabetes and kidney disease. Adv Chronic Kidney Dis. 2018;25:121–32.

Article  Google Scholar 

Lunyera J, Mohottige D, Von Isenburg M, Jeuland M, Patel UD, Stanifer JW. CKD of uncertain etiology: a systematic review. Clin J Am Soc Nephrol. 2016;11:379–85.

Article  CAS  PubMed  Google Scholar 

Correa-Rotter R, Wesseling C, Johnson RJ. CKD of unknown origin in Central America: the case for a Mesoamerican nephropathy. Am J Kidney Dis. 2014;63:506–20.

Article  PubMed Central  Google Scholar 

Abraham G, Varughese S, Thandavan T, Iyengar A, Fernando E, Naqvi SA, et al. Chronic kidney disease hotspots in developing countries in South Asia. Clin Kidney J. 2016;9:135–41.

Article  PubMed  Google Scholar 

Anand S, Staniec A, Montez-Rath M, Vlahos P. Using GIS mapping to track hot spots of kidney disease in California. N Engl J Med. 2020;382:2265–7.

Article  PubMed  Google Scholar 

Ransom KM, Nolan BT, Stackelberg PE, Belitz K, Fram MS. Machine learning predictions of nitrate in groundwater used for drinking supply in the conterminous United States. Sci Total Environ. 2022;807:151065.

Article  CAS  PubMed  Google Scholar 

Jeffries-Stokes CA, Stokes AM, McDonald L, Evans S, Anderson Deceased L, Robinson PM. Risk factors for renal disease and diabetes in remote Australia - findings from The Western Desert Kidney Health Project. Rural Remote Health. 2020;20:5440.

PubMed  Google Scholar 

Indika S, Wei Y, Cooray T, Ritigala T, Jinadasa KBSN, Weragoda SK, et al. Groundwater-based drinking water supply in Sri Lanka: status and perspectives. Water. 2022;14:1428.

Article  CAS  Google Scholar 

Mirmiran P, Bahadoran Z, Golzarand M, Asghari G, Azizi F. Consumption of nitrate containing vegetables and the risk of chronic kidney disease: tehran lipid and glucose study. Ren Fail. 2016;38:937–44.

Article  CAS  PubMed  Google Scholar 

Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for nitrate and nitrite. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service. 2017.

IARC. IARC monographs on the evaluation of carcinogenic risks to humans. Ingested nitrate and nitrite, and cyanobacterial peptide toxins. IARC Monogr Eval Carcinog Risks Hum. 2010;94:1–412.

Google Scholar 

Picetti R, Deeney M, Pastorino S, Miller MR, Shah A, Leon DA, et al. Nitrate and nitrite contamination in drinking water and cancer risk: a systematic review with meta-analysis. Environ Res. 2022;210:112988.

Article  CAS  PubMed  Google Scholar 

Ward MH, Jones RR, Brender JD, de Kok TM, Weyer PJ, Nolan BT, et al. Drinking water nitrate and human health: an updated review. Int J Environ Res Public Health. 2018;15:1557.

Article  PubMed Central  Google Scholar 

Robbiano L, Mereto E, Corbu C, Brambilla G. DNA damage induced by seven N-nitroso compounds in primary cultures of human and rat kidney cells. Mutat Res. 1996;368:41–7.

Article  CAS  Google Scholar 

Jalili C, Moradi D, Roshankhah S, Salahshoor MR. Effect of pentoxifylline on kidney damage induced by nitrosamine in male rats. Res Pharm Sci. 2019;14:64–73.

Article  PubMed  PubMed Central  Google Scholar 

Verma A, Ahmed B, Anwar F, Rahman M, Patel DK, Kaithwas G, et al. Novel glycoside from Wedelia calendulacea inhibits diethyl nitrosamine-induced renal cancer via downregulating the COX-2 and PEG(2) through nuclear factor-κB pathway. Inflammopharmacology. 2017;25:159–75.

Article  CAS  PubMed  Google Scholar 

Alavanja MC, Sandler DP, McMaster SB, Zahm SH, McDonnell CJ, Lynch CF, et al. The agricultural health study. Environ Health Perspect. 1996;104:362–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

National Cancer Institute. Diet history questionnaire, version 1.0. Bethesda, MD: National Institutes of Health, Applied Research Program. 2007. https://epi.grants.cancer.gov/dhq/forms/. Accessed December 13, 2023.

Manley CK, Spaur M, Madrigal JM, Fisher JA, Jones RR, Parks CG, et al. Drinking water sources and water quality in a prospective agricultural cohort. Environ Epidemiol. 2022;6:e210.

Article  PubMed  PubMed Central  Google Scholar 

Messier KP, Wheeler DC, Flory AR, Jones RR, Patel D, Nolan BT, et al. Modeling groundwater nitrate exposure in private wells of North Carolina for the Agricultural Health Study. Sci Total Environ. 2019;655:512–9.

Article  CAS  PubMed  Google Scholar 

Wheeler DC, Nolan BT, Flory AR, DellaValle CT, Ward MH. Modeling groundwater nitrate concentrations in private wells in Iowa. Sci Total Environ. 2015;536:481–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Inoue-Choi M, Virk-Baker MK, Aschebrook-Kilfoy B, Cross AJ, Subar AF, Thompson FE, et al. Development and calibration of a dietary nitrate and nitrite database in the NIH-AARP Diet and Health Study. Public Health Nutr. 2016;19:1934–43.

Article  Google Scholar 

National Cancer Institute. DHQ Nutrient Database. Bethesda, MD: National Institutes of Health, Applied Research Program. https://epi.grants.cancer.gov/dhq/database/. Accessed December 13, 2023.

Cross AJ, Harnly JM, Ferrucci LM, Risch A, Mayne ST, Sinha R. Developing a heme iron database for meats according to meat type, cooking method and doneness level. Food Nutr Sci. 2012;3:905–13.

CAS  PubMed  PubMed Central  Google Scholar 

U.S. Renal Data System. 2021 Researcher’s Guide to the USRDS Database. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. 2021.

Cross AJ, Pollock JR, Bingham SA. Haem, not protein or inorganic iron, is responsible for endogenous intestinal N-nitrosation arising from red meat. Cancer Res. 2003;63:2358–60.

CAS  PubMed  Google Scholar 

Mirvish SS. Effects of vitamins C and E on N-nitroso compound formation, carcinogenesis, and cancer. Cancer. 1986;58:1842–50.

Article  CAS  Google Scholar 

Bahadoran Z, Ghasemi A, Mirmiran P, Azizi F, Hadaegh F. Beneficial effects of inorganic nitrate/nitrite in type 2 diabetes and its complications. Nutr Metab. 2015;12:16.

Article  Google Scholar 

Lebov JF, Engel LS, Richardson D, Hogan SL, Hoppin JA, Sandler DP. Pesticide use and risk of end-stage renal disease among licensed pesticide applicators in the Agricultural Health Study. Occup Environ Med. 2016;73:3–12.

Article  Google Scholar 

Lebov JF, Engel LS, Richardson D, Hogan SL, Sandler DP, Hoppin JA. Pesticide exposure and end-stage renal disease risk among wives of pesticide applicators in the Agricultural Health Study. Environ Res. 2015;143:198–210.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Willett WC, Howe GR, Kushi LH. Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr. 1997;65:1220S–8S.

Article  CAS  PubMed  Google Scholar 

Xia J, Wang L, Ma Z, Zhong L, Wang Y, Gao Y, et al. Cigarette smoking and chronic kidney disease in the general population: a systematic review and meta-analysis of prospective cohort studies. Nephrol Dial Transpl. 2017;32:475–87.

Article  CAS  Google Scholar 

Dharma-Wardana MW, Amarasiri SL, Dharmawardene N, Panabokke CR. Chronic kidney disease of unknown aetiology and ground-water ionicity: study based on Sri Lanka. Environ Geochem Health. 2015;37:221–31.

Article  CAS  PubMed  Google Scholar 

Gobalarajah K, Subramaniam P, Jayawardena UA, Rasiah G, Rajendra S, Prabagar J. Impact of water quality on Chronic Kidney Disease of unknown etiology (CKDu) in Thunukkai Division in Mullaitivu District, Sri Lanka. BMC Nephrol. 2020;21:507.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Volkmer BG, Ernst B, Simon J, Kuefer R, Bartsch G Jr., Bach D, et al. Influence of nitrate levels in drinking water on urological malignancies: a community-based cohort study. BJU Int. 2005;95:972–6.

Article  CAS  PubMed  Google Scholar 

Weyer PJ, Cerhan JR, Kross BC, Hallberg GR, Kantamneni J, Breuer G, et al. Municipal drinking water nitrate level and cancer risk in older women: the Iowa Women’s Health Study. Epidemiology. 2001;12:327–38.

Article  CAS  PubMed  Google Scholar 

Jones RR, Weyer PJ, DellaValle CT, Robien