Association between serum lipoprotein(a) and mildly reduced eGFR: a cross-sectional study

Kalantar-Zadeh K, Jafar TH, Nitsch D, Neuen BL, Perkovic V. Chronic Kidney Disease. Lancet. 2021;398(10302):786–802.

Article  CAS  PubMed  Google Scholar 

Global R. National burden of chronic Kidney Disease, 1990–2017: a systematic analysis for the global burden of Disease Study 2017. Lancet. 2020;395(10225):709–33.

Article  Google Scholar 

Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, et al. Chronic Kidney Disease: global dimension and perspectives. Lancet. 2013;382(9888):260–72.

Article  PubMed  Google Scholar 

Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm LL, et al. Kidney Disease as a risk factor for development of Cardiovascular Disease: a statement from the American Heart Association Councils on kidney in Cardiovascular Disease, High Blood Pressure research, clinical cardiology, and Epidemiology and Prevention. Circulation. 2003;108(17):2154–69.

Article  PubMed  Google Scholar 

Grams ME, Yang W, Rebholz CM, Wang X, Porter AC, Inker LA, et al. Risks of adverse events in Advanced CKD: the chronic renal insufficiency cohort (CRIC) study. Am J Kidney Dis. 2017;70(3):337–46.

Article  PubMed  PubMed Central  Google Scholar 

Levin A, Stevens PE, Bilous RW, Coresh J, De Francisco AL, De Jong PE, et al. Kidney Disease: improving global outcomes (KDIGO) CKD Work Group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic Kidney Disease. Kidney Int Supplements. 2013;3(1):1–150.

Google Scholar 

Wernisch S, Pennathur S. Application of differential mobility-mass spectrometry for untargeted human plasma metabolomic analysis. Anal Bioanal Chem. 2019;411(24):6297–308.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong X, Wu D, Jia C, Ruan Y, Feng X, Wang G, et al. Low ankle-brachial index is associated with early-stage chronic Kidney Disease in type 2 diabetic patients Independent of albuminuria. PLoS ONE. 2014;9(10): e109641.

Article  PubMed  PubMed Central  Google Scholar 

Fox CS, Larson MG, Leip EP, Culleton B, Wilson PW, Levy D. Predictors of new-onset Kidney Disease in a community-based population. JAMA. 2004;291(7):844–50.

Article  CAS  PubMed  Google Scholar 

O’Seaghdha CM, Lyass A, Massaro JM, Meigs JB, Coresh J, D’Agostino RB Sr, et al. A risk score for chronic Kidney Disease in the general population. Am J Med. 2012;125(3):270–7.

Article  PubMed  PubMed Central  Google Scholar 

Ataklte F, Song RJ, Upadhyay A, Musa Yola I, Vasan RS, Xanthakis V. Association of mildly reduced kidney function with Cardiovascular Disease: the Framingham Heart Study. J Am Heart Assoc. 2021;10(16): e020301.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schmidt K, Noureen A, Kronenberg F, Utermann G. Structure, function, and genetics of lipoprotein (a). J Lipid Res. 2016;57(8):1339–59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yeang C, Gordts PL, Tsimikas S. Novel lipoprotein(a) catabolism pathway via apolipoprotein(a) recycling: adding the plasminogen receptor PlgR(KT) to the list. Circ Res. 2017;120(7):1050–2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eckardstein AV. Lipoprotein(a). Eur Heart J. 2017;38(20):1530–2.

Article  PubMed  Google Scholar 

Reith C, Armitage J. Management of residual risk after statin therapy. Atherosclerosis. 2016;245:161–70.

Article  CAS  PubMed  Google Scholar 

Verbeek R, Sandhu MS, Hovingh GK, Sjouke B, Wareham NJ, Zwinderman AH, et al. Lipoprotein(a) improves Cardiovascular Risk Prediction based on established risk algorithms. J Am Coll Cardiol. 2017;69(11):1513–5.

Article  CAS  PubMed  Google Scholar 

Erqou S, Kaptoge S, Perry PL, Di Angelantonio E, Thompson A, White IR, et al. Lipoprotein(a) concentration and the risk of coronary Heart Disease, stroke, and nonvascular mortality. JAMA. 2009;302(4):412–23.

Article  CAS  PubMed  Google Scholar 

Forbes CA, Quek RG, Deshpande S, Worthy G, Wolff R, Stirk L, et al. The relationship between Lp(a) and CVD outcomes: a systematic review. Lipids Health Dis. 2016;15:95.

Article  PubMed  PubMed Central  Google Scholar 

Xuan L, Wang T, Dai H, Wang B, Xiang J, Wang S, et al. Serum lipoprotein (a) associates with a higher risk of reduced renal function: a prospective investigation. J Lipid Res. 2020;61(10):1320–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang Z, Yang Y, Lu J, Liang J, He Y, Yu Y, et al. Association of Lipoprotein(a)-Associated Mortality and the estimated glomerular filtration rate level in patients undergoing coronary angiography: a 51,500 Cohort Study. Front Cardiovasc Med. 2021;8: 747120.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin J, Reilly MP, Terembula K, Wilson FP. Plasma lipoprotein(a) levels are associated with mild renal impairment in type 2 diabetics Independent of albuminuria. PLoS ONE. 2014;9(12): e114397.

Article  PubMed  PubMed Central  Google Scholar 

Kovesdy CP, Astor BC, Longenecker JC, Coresh J. Association of kidney function with serum lipoprotein(a) level: the third National Health and Nutrition Examination Survey (1991–1994). Am J Kidney Dis. 2002;40(5):899–908.

Article  CAS  PubMed  Google Scholar 

Zhang H, Chen R, Xu X, Yang M, Xu W, Xiang S, et al. Metabolically healthy obesity is associated with higher risk of both hyperfiltration and mildly reduced estimated glomerular filtration rate: the role of serum uric acid in a cross-sectional study. J Transl Med. 2023;21(1):216.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang X, Jiang X, Wang L, Chen L, Wu Y, Gao P, et al. Visceral adipose accumulation increased the risk of hyperuricemia among middle-aged and elderly adults: a population-based study. J Transl Med. 2019;17(1):341.

Article  PubMed  PubMed Central  Google Scholar 

Inker LA, Schmid CH, Tighiouart H, Eckfeldt JH, Feldman HI, Greene T, et al. Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med. 2012;367(1):20–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen C, Lu FC. The guidelines for prevention and control of overweight and obesity in Chinese adults. Biomed Environ Sci. 2004;17 Suppl:1–36.

PubMed  Google Scholar 

Sechi LA, Zingaro L, De Carli S, Sechi G, Catena C, Falleti E, et al. Increased serum lipoprotein(a) levels in patients with early Renal Failure. Ann Intern Med. 1998;129(6):457–61.

Article  CAS  PubMed  Google Scholar 

Hopewell JC, Haynes R, Baigent C. The role of lipoprotein (a) in chronic Kidney Disease. J Lipid Res. 2018;59(4):577–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Emdin CA, Khera AV, Natarajan P, Klarin D, Won HH, Peloso GM, et al. Phenotypic characterization of genetically lowered human lipoprotein(a) levels. J Am Coll Cardiol. 2016;68(25):2761–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yun JS, Ahn YB, Song KH, Yoo KD, Park YM, Kim HW, et al. Lipoprotein(a) predicts a new onset of chronic Kidney Disease in people with type 2 Diabetes Mellitus. Diabet Med. 2016;33(5):639–43.

Article  CAS  PubMed  Google Scholar 

Provenzano M, Andreucci M, De Nicola L, Garofalo C, Battaglia Y, Borrelli S, et al. The role of prognostic and predictive biomarkers for assessing Cardiovascular risk in chronic Kidney Disease patients. Biomed Res Int. 2020;2020:2314128.

Article  PubMed  PubMed Central  Google Scholar 

Gencer B, Kronenberg F, Stroes ES, Mach F. Lipoprotein(a): the revenant. Eur Heart J. 2017;38(20):1553–60.

Article  CAS  PubMed  Google Scholar 

Obisesan OH, Kou M, Wang FM, Boakye E, Honda Y, Uddin SMI, et al. Lipoprotein(a) and subclinical vascular and valvular calcification on Cardiac Computed Tomography: the Atherosclerosis risk in communities Study. J Am Heart Assoc. 2022;11(11): e024870.

Article  PubMed  PubMed Central  Google Scholar 

Yeang C, Cotter B, Tsimikas S. Experimental animal models evaluating the Causal Role of Lipoprotein(a) in Atherosclerosis and aortic stenosis. Cardiovasc Drugs Ther. 2016;30(1):75–85.

Article  CAS  PubMed  Google Scholar 

Gloviczki ML, Keddis MT, Garovic VD, Friedman H, Herrmann S, McKusick MA, et al. TGF expression and macrophage accumulation in atherosclerotic renal artery stenosis. Clin J Am Soc Nephrol. 2013;8(4):546–53.

Article  PubMed  Google Scholar 

Schachinger V, Halle M, Minners J, Berg A, Zeiher AM. Lipoprotein(a) selectively impairs receptor-mediated endothelial vasodilator function of the human coronary circulation. J Am Coll Cardiol. 1997;30(4):927–34.

Comments (0)

No login
gif