Inverted papillomas are benign epithelial tumors with an incidence of 0.5 to 1.5 cases per 100,000 inhabitants per year [1,2]. The latest edition of the WHO classification of head and neck tumors confirmed the existence of the three previously described types of sinonasal papillomas, the inverted papilloma (IP), the exophytic papilloma (EP) and the oncocytic papilloma (OP), removing the eponym of Schneiderian for the IP [3]. IP and OP originate mostly from the lateral wall of the nasal fossa while EP originates more frequently from the anterior areas of the nasal septum. IPs are the most frequent, representing approximately 60 % of all papillomas. They are more frequent in males (3:1) and are usually diagnosed between the 5th and 6th decade of life. >95 % of cases are unilateral and have their origin preferentially in the ethmoid and/or lateral wall of the nasal fossa [4,5]. Their etiology is unknown, although for years the possible relationship with human papillomavirus (HPV) has been suggested in their pathogenesis. It is not clear whether the presence of HPV is a colonization or is actually an etiologic factor present in both recurrences and possible malignant transformations [6]. The current treatment for most IP is the endoscopic endonasal approach (EEA) with a recurrence rate according to the largest series ranging from 6 % to 25% [[7], [8], [9]]. The aim of our study was to present the results after treatment of IPs, considering pathological, immunohistochemical and molecular features of recurrence.