Matzkin, E. G., DeMaio, M., Charles, J. F., & Franklin, C. C. (2019). Diagnosis and treatment of osteoporosis: What orthopaedic surgeons need to know. Journal of American Academy of Orthopaedic Surgeons, 27(20), e902–e912.

Article  Google Scholar 

Reid, I. R. (2015). Short-term and long-term effects of osteoporosis therapies. Nature Reviews. Endocrinology, 11(7), 418–428.

Article  CAS  PubMed  Google Scholar 

Coughlan, T., & Dockery, F. (2014). Osteoporosis and fracture risk in older people. Clinical Medicine (London)., 14(2), 187–191.

Article  PubMed Central  Google Scholar 

Burge, R., Dawson-Hughes, B., Solomon, D. H., Wong, J. B., King, A., & Tosteson, A. (2007). Incidence and economic burden of osteoporosis-related fractures in the United States, 2005–2025. Journal of Bone and Mineral Research, 22(3), 465–475.

Article  PubMed  Google Scholar 

Ström, O., Borgström, F., Kanis, J. A., Compston, J., Cooper, C., McCloskey, E. V., et al. (2011). Osteoporosis: Burden, health care provision and opportunities in the EU: A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Archives of Osteoporosis, 6, 59–155.

Article  PubMed  Google Scholar 

Osteoporosis on the rise in India among young adults [Internet]. https://www.deccanchronicle.com/lifestyle/health-and-wellbeing/011119/osteoporosis-on-the-rise-in-india-among-young-adults.html. Cited 24 Jun 2023.

Brown, C. (2017). Osteoporosis: staying strong. Nature, 550(7674), S15–S17.

Article  CAS  PubMed  Google Scholar 

Raggatt, L. J., & Partridge, N. C. (2010). Cellular and molecular mechanisms of bone remodeling. Journal of Biological Chemistry., 285(33), 25103–25108.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Canalis, E. (2013). Wnt signalling in osteoporosis: Mechanisms and novel therapeutic approaches. Nature Reviews. Endocrinology, 9(10), 575–583.

Article  CAS  PubMed  Google Scholar 

Alexandre, C., & Vico, L. (2011). Pathophysiology of bone loss in disuse osteoporosis. Joint, Bone, Spine, 78(6), 572–576.

Article  CAS  PubMed  Google Scholar 

Doty, S. B., & DiCarlo, E. F. (1995). Pathophysiology of immobilization osteoporosis. Current Opinion in Orthopaedics, 6(5), 45–49.

Article  CAS  PubMed  Google Scholar 

Sibonga, J., Matsumoto, T., Jones, J., Shapiro, J., Lang, T., Shackelford, L., et al. (2019). Resistive exercise in astronauts on prolonged spaceflights provides partial protection against spaceflight-induced bone loss. Bone, 128, 112037.

Article  CAS  PubMed  Google Scholar 

Mazziotti, G., Formenti, A. M., Adler, R. A., Bilezikian, J. P., Grossman, A., Sbardella, E., et al. (2016). Glucocorticoid-induced osteoporosis: Pathophysiological role of GH/IGF-I and PTH/VITAMIN D axes, treatment options and guidelines. Endocrine, 54(3), 603–611.

Article  CAS  PubMed  Google Scholar 

Whittier, X., & Saag, K. G. (2016). Glucocorticoid-induced Osteoporosis. Rheumatic Disease Clinics of North America., 42(1), 177–189.

Article  PubMed  Google Scholar 

Kim, H. Y., & Kim, Y. (2019). Associations of obesity with osteoporosis and metabolic syndrome in Korean postmenopausal women: A cross-sectional study using national survey data. Archives of Osteoporosis, 14(1), 64.

Article  PubMed  Google Scholar 

Xiao, W., Li, S., Pacios, S., Wang, Y., & Graves, D. T. (2016). Bone remodeling under pathological conditions. Frontiers of Oral Biology, 18, 17–27.

Article  PubMed  Google Scholar 

Yuan, F. L., Xu, R. S., Jiang, D. L., He, X. L., Su, Q., Jin, C., et al. (2015). Leonurine hydrochloride inhibits osteoclastogenesis and prevents osteoporosis associated with estrogen deficiency by inhibiting the NF-κB and PI3K/Akt signaling pathways. Bone, 75, 128–137.

Article  CAS  PubMed  Google Scholar 

Suchacki, K. J., Cawthorn, W. P., & Rosen, C. J. (2016). Bone marrow adipose tissue: formation, function and regulation. Current Opinion in Pharmacology, 28, 50–56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aspray, T. J., & Hill, T. R. (2019). Osteoporosis and the ageing skeleton. SubCellular Biochemistry, 91, 453–476.

Article  CAS  PubMed  Google Scholar 

Khosla, S., & Hofbauer, L. C. (2017). Osteoporosis treatment: recent developments and ongoing challenges. The Lancet Diabetes & Endocrinology, 5(11), 898–907.

Article  Google Scholar 

Sølling, A. S. K., Harsløf, T., & Langdahl, B. (2019). Current status of bone-forming therapies for the management of osteoporosis. Drugs and Aging, 36(7), 625–638.

Article  PubMed  Google Scholar 

Cano, A., Chedraui, P., Goulis, D. G., Lopes, P., Mishra, G., Mueck, A., et al. (2018). Calcium in the prevention of postmenopausal osteoporosis: EMAS clinical guide. Maturitas, 107, 7–12.

Article  CAS  PubMed  Google Scholar 

Paschalis, E. P., Gamsjaeger, S., Hassler, N., Fahrleitner-Pammer, A., Dobnig, H., Stepan, J. J., et al. (2017). Vitamin D and calcium supplementation for three years in postmenopausal osteoporosis significantly alters bone mineral and organic matrix quality. Bone, 95, 41–46.

Article  CAS  PubMed  Google Scholar 

Weaver, C. M., Alexander, D. D., Boushey, C. J., Dawson-Hughes, B., Lappe, J. M., LeBoff, M. S., et al. (2016). Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. Osteoporosis International, 27, 367–376.

Article  CAS  PubMed  Google Scholar 

Pagnotti, G. M., Styner, M., Uzer, G., Patel, V. S., Wright, L. E., Ness, K. K., et al. (2019). Combating osteoporosis and obesity with exercise: Leveraging cell mechanosensitivity. Nature Reviews. Endocrinology, 15(6), 339–355.

Article  PubMed  PubMed Central  Google Scholar 

Feng, X., & McDonald, J. M. (2011). Disorders of bone remodeling. Annual Review of Pathology, 6, 121–145.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Drake, M. T., Clarke, B. L., & Khosla, S. (2008). Bisphosphonates: Mechanism of action and role in clinical practice. Mayo Clinic Proceedings, 83(9), 1032–1045.

Article  CAS  PubMed  Google Scholar 

Levin, V. A., Jiang, X., & Kagan, R. (2018). Estrogen therapy for osteoporosis in the modern era. Osteoporosis International, 29(5), 1049–1055.

Article  CAS  PubMed  Google Scholar 

Ellis, A. J., Hendrick, V. M., Williams, R., & Komm, B. S. (2015). Selective estrogen receptor modulators in clinical practice: A safety overview. Expert Opinion on Drug Safety, 14(6), 921–934.

Article  CAS  PubMed  Google Scholar 

Guañabens, N., Moro-Álvarez, M. J., Casado, E., Blanch-Rubió, J., Gómez-Alonso, C., Díaz-Guerra, G. M., et al. (2019). The next step after anti-osteoporotic drug discontinuation: An up-to-date review of sequential treatment. Endocrine, 64(3), 441–455.

Article  PubMed  Google Scholar 

Xu, Z., Fan, C., Zhao, X., & Tao, H. (2016). Treatment of osteoporosis with eldecalcitol, a new vitamin D analog: A comprehensive review and meta-analysis of randomized clinical trials. Drug Design, Development and Therapy., 10, 509–517.

CAS  PubMed  PubMed Central  Google Scholar 

Noguchi, Y., Kawate, H., Nomura, M., & Takayanagi, R. (2013). Eldecalcitol for the treatment of osteoporosis. Clinical Interventions in Aging, 8, 1313–1321.

PubMed  PubMed Central  Google Scholar 

Iba, K., Sonoda, T., Takada, J., Dohke, T., & Yamashita, T. (2017). Further significant effects of eldecalcitol on bone resorption markers and bone mineral density in postmenopausal osteoporosis patients having undergone long-term bisphosphonate treatment. Journal of Bone and Mineral Metabolism, 35(2), 171–176.

Article  CAS  PubMed  Google Scholar 

Cosman, F., Crittenden, D. B., Adachi, J. D., Binkley, N., Czerwinski, E., Ferrari, S., et al. (2016). Romosozumab treatment in postmenopausal women with osteoporosis. The New England Journal of Medicine, 375(16), 1532–1543. https://doi.org/10.1056/NEJMoa1607948

Article  CAS  PubMed  Google Scholar 

Tsai, J., Uihlein, A., Burnett-Bowie, S., Neer, R., Zhu, Y., Derrico, N., et al. (2015). Comparative effects of teriparatide, denosumab, and combination therapy on peripheral compartmental bone density, microarchitecture, and estimated strength: The DATA-HRpQCT study. Journal of Bone and Mineral Research, 30(1), 39–45.

Article  CAS  PubMed  Google Scholar 

Hofbauer, L. C., & Schoppet, M. (2004). Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases. JAMA, 292(4), 490–495.

Article  CAS  PubMed  Google Scholar 

Shea, B., Wells, G., Cranney, A., Zytaruk, N., Robinson, V., Griffith, L., et al. (2002). Meta-analyses of therapies for postmenopausal osteoporosis. VII. Meta-analysis of calcium supplementation for the prevention of postmenopausal osteoporosis. Endocrine Reviews., 23(4), 552–559.

Article  CAS  PubMed  Google Scholar 

Je, R., G, A., R, P., Az, L., C, K., & M, S., et al. (2002). Risks and benefits of estrogen plus progestin in healthy postmenopausal