United Nations Department of Economic and Social Affairs, Population Division (2022). World Population Prospects 2022: Summary of Results. UN DESA/POP/2022/TR/NO. 3. https://www.un.org/development/desa/pd/content/World-Population-Prospects-2022

GBD 2016 Dementia Collaborators (2019) Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet. Neurology 18(1):88–106. https://doi.org/10.1016/S1474-4422(18)30403-4

Article  Google Scholar 

Scheltens P, De Strooper B, Kivipelto M, Holstege H, Chételat G, Teunissen CE, Cummings J, van der Flier WM (2021) Alzheimer’s disease. Lancet (London, England) 397(10284):1577–1590. https://doi.org/10.1016/S0140-6736(20)32205-4

Article  CAS  PubMed  Google Scholar 

Gonzales MM, Garbarino VR, Pollet E, Palavicini JP, Kellogg DL Jr, Kraig E, Orr ME (2022) Biological aging processes underlying cognitive decline and neurodegenerative disease. J Clin Investig 132(10):e158453. https://doi.org/10.1172/JCI158453

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang X, Zhao X, Li B, Cai Y, Zhang S, Wan Q, Yu F (2022) Comparative efficacy of various exercise interventions on cognitive function in patients with mild cognitive impairment or dementia: A systematic review and network meta-analysis. J Sport Health Sci 11(2):212–223. https://doi.org/10.1016/j.jshs.2021.05.003

Article  PubMed  Google Scholar 

Valenzuela PL, Castillo-García A, Morales JS, de la Villa P, Hampel H, Emanuele E, Lista S, Lucia A (2020) Exercise benefits on Alzheimer’s disease: State-of-the-science. Ageing Res Rev 62:101108. https://doi.org/10.1016/j.arr.2020.101108

Article  CAS  PubMed  Google Scholar 

Erickson KI, Donofry SD, Sewell KR, Brown BM, Stillman CM (2022) Cognitive aging and the promise of physical activity. Annu Rev Clin Psychol 18:417–442. https://doi.org/10.1146/annurev-clinpsy-072720-014213

Article  PubMed  Google Scholar 

GBD 2017 Disease and Injury Incidence and Prevalence Collaborators (2018) Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet (London, England) 392(10159):1789–1858. https://doi.org/10.1016/S0140-6736(18)32279-7

Article  Google Scholar 

Ahn J, Kim M (2023) Effects of exercise therapy on global cognitive function and depression in older adults with mild cognitive impairment: a systematic review and meta-analysis. Arch Gerontol Geriatr 106:104855. https://doi.org/10.1016/j.archger.2022.104855]

Article  PubMed  Google Scholar 

Shahnawaz Z, Reppermund S, Brodaty H, Crawford JD, Draper B, Trollor JN, Sachdev PS (2013) Prevalence and characteristics of depression in mild cognitive impairment: the Sydney Memory and Ageing Study. Acta Psychiatr Scand 127(5):394–402. https://doi.org/10.1111/acps.12008

Article  CAS  PubMed  Google Scholar 

Huang IC, Chang TS, Chen C, Sung JY (2022) Effect of vortioxetine on cognitive impairment in patients with major depressive disorder: a systematic review and meta-analysis of randomized controlled trials. Int J Neuropsychopharmacol 25(12):969–978. https://doi.org/10.1093/ijnp/pyac054

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beckett CW, Niklison-Chirou MV (2022) The role of immunomodulators in treatment-resistant depression: case studies. Cell death discovery 8(1):367. https://doi.org/10.1038/s41420-022-01147-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferri F, Deschênes SS, Power N, Schmitz N (2021) Associations between cognitive function, metabolic factors and depression: a prospective study in Quebec, Canada. J Affect Disord 283:77–83. https://doi.org/10.1016/j.jad.2021.01.039

Article  PubMed  Google Scholar 

Zipf G, Chiappa M, Porter KS, Ostchega Y, Lewis BG, Dostal J (2013) National health and nutrition examination survey: plan and operations, 1999–2010. Vital Health Stat 1(56):1–37. https://pubmed.ncbi.nlm.nih.gov/25078429/

Keating XD, Zhou K, Liu X, Hodges M, Liu J, Guan J, Phelps A, Castro-Piñero J (2019) Reliability and concurrent validity of global physical activity questionnaire (GPAQ): a systematic review. Int J Environ Res Public Health 16(21):4128. https://doi.org/10.3390/ijerph16214128

Article  PubMed  PubMed Central  Google Scholar 

US Department of Health and Human Services. Physical Activity Guidelines for Americans. https://health.gov/sites/default/files/2019-09/paguide.pdf (August 2020, date last accessed)

Levis B, Benedetti A, Thombs BD, DEPRESsion Screening Data (DEPRESSD) Collaboration (2019) Accuracy of Patient Health Questionnaire-9 (PHQ-9) for screening to detect major depression: individual participant data meta-analysis. BMJ (Clin Res ed) 365:l1476. https://doi.org/10.1136/bmj.l1476

Article  Google Scholar 

Lafont S, Marin-Lamellet C, Paire-Ficout L, Thomas-Anterion C, Laurent B, Fabrigoule C (2010) The wechsler digit symbol substitution test as the best indicator of the risk of impaired driving in Alzheimer disease and normal aging. Dement Geriatr Cogn Disord 29(2):154–163. https://doi.org/10.1159/000264631

Article  PubMed  Google Scholar 

Jaeger J (2018) Digit symbol substitution test: the case for sensitivity over specificity in neuropsychological testing. J Clin Psychopharmacol 38(5):513–519. https://doi.org/10.1097/JCP.0000000000000941

Article  PubMed  PubMed Central  Google Scholar 

Morris JC, Heyman A, Mohs RC, Hughes JP, van Belle G, Fillenbaum G, Mellits ED, Clark C (1989) The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer’s disease. Neurology 39(9):1159–1165. https://doi.org/10.1212/wnl.39.9.1159

Article  CAS  PubMed  Google Scholar 

Canning SJ, Leach L, Stuss D, Ngo L, Black SE (2004) Diagnostic utility of abbreviated fluency measures in Alzheimer disease and vascular dementia. Neurology 62(4):556–562. https://doi.org/10.1212/wnl.62.4.556

Article  PubMed  Google Scholar 

Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ, Heart N, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, & National High Blood Pressure Education Program Coordinating Committee (2003) The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 289(19):2560–2572. https://doi.org/10.1001/jama.289.19.2560

Article  CAS  PubMed  Google Scholar 

Hirshkowitz M, Whiton K, Albert SM, Alessi C, Bruni O, DonCarlos L, Hazen N, Herman J, Katz ES, Kheirandish-Gozal L, Neubauer DN, O’Donnell AE, Ohayon M, Peever J, Rawding R, Sachdeva RC, Setters B, Vitiello MV, Ware JC, Adams Hillard PJ (2015) National Sleep Foundation’s sleep time duration recommendations: methodology and results summary. Sleep Health 1(1):40–43. https://doi.org/10.1016/j.sleh.2014.12.010

Article  PubMed  Google Scholar 

Morley JE (2018) An overview of cognitive impairment. Clin Geriatr Med 34(4):505–513. https://doi.org/10.1016/j.cger.2018.06.003

Article  PubMed  Google Scholar 

Salthouse TA (2019) Trajectories of normal cognitive aging. Psychol Aging 34(1):17–24. https://doi.org/10.1037/pag0000288

Article  PubMed  Google Scholar 

Ungvari Z, Toth P, Tarantini S, Prodan CI, Sorond F, Merkely B, Csiszar A (2021) Hypertension-induced cognitive impairment: from pathophysiology to public health. Nat Rev Nephrol 17(10):639–654. https://doi.org/10.1038/s41581-021-00430-6

Article  PubMed  PubMed Central  Google Scholar 

Rost NS, Brodtmann A, Pase MP, van Veluw SJ, Biffi A, Duering M, Hinman JD, Dichgans M (2022) Post-stroke cognitive impairment and dementia. Circ Res 130(8):1252–1271. https://doi.org/10.1161/CIRCRESAHA.122.319951

Article  CAS  PubMed  Google Scholar 

Sanders LMJ, Hortobágyi T, Karssemeijer EGA, Van der Zee EA, Scherder EJA, van Heuvelen MJG (2020) Effects of low- and high-intensity physical exercise on physical and cognitive function in older persons with dementia: a randomized controlled trial. Alzheimer’s Res Ther 12(1):28. https://doi.org/10.1186/s13195-020-00597-3

Article  CAS  Google Scholar 

Casas-Herrero Á, Sáez de Asteasu ML, Antón-Rodrigo I, Sánchez-Sánchez JL, Montero-Odasso M, Marín-Epelde I, Ramón-Espinoza F, Zambom-Ferraresi F, Petidier-Torregrosa R, Elexpuru-Estomba J, Álvarez-Bustos A, Galbete A, Martínez-Velilla N, Izquierdo M (2022) Effects of Vivifrail multicomponent intervention on functional capacity: a multicentre, randomized controlled trial. J Cachexia Sarcopenia Muscle 13(2):884–893. https://doi.org/10.1002/jcsm.12925

Article  PubMed  PubMed Central  Google Scholar 

Zotcheva E, Håberg AK, Wisløff U, Salvesen Ø, Selbæk G, Stensvold D, Ernstsen L (2022) Effects of 5 years aerobic exercise on cognition in older adults: the generation 100 study: a randomized controlled trial. Sports Med (Auckland, N.Z.) 52(7):1689–1699. https://doi.org/10.1007/s40279-021-01608-5

Article  Google Scholar 

Wei J, Hou R, Xie L, Chandrasekar EK, Lu H, Wang T, Li C, Xu H (2021) Sleep, sedentary activity, physical activity, and cognitive function among older adults: the national health and nutrition examination survey, 2011–2014. J Sci Med Sport 24(2):189–194. https://doi.org/10.1016/j.jsams.2020.09.013

Article  PubMed  Google Scholar 

Venegas-Sanabria LC, Cavero-Redondo I, Martínez-Vizcaino V, Cano-Gutierrez CA, Álvarez-Bueno C (2022) Effect of multicomponent exercise in cognitive impairment: a systematic review and meta-analysis. BMC Geriatr 22(1):617. https://doi.org/10.1186/s12877-022-03302-1

Article  PubMed  PubMed Central  Google Scholar 

de Oliveira Silva F, Ferreira JV, Plácido J, Sant’Anna P, Araújo J, Marinho V, Laks J, Camaz Deslandes A (2019) Three months of multimodal training contributes to mobility and executive function in elderly individuals with mild cognitive impairment, but not in those with Alzheimer’s disease: A randomized controlled trial. Maturitas 126:28–33. https://doi.org/10.1016/j.maturitas.2019.04.217

Article  PubMed  Google Scholar 

Bennett S, Thomas AJ (2014) Depression and dementia: cause, consequence or coincidence? Maturitas 79(2):184–190. https://doi.org/10.1016/j.maturitas.2014.05.009

Article  PubMed  Google Scholar 

Hayley S, Hakim AM, Albert PR (2021) Depression, dementia and immune dysregulation. Brain : J Neurol 144(3):746–760. https://doi.org/10.1093/brain/awaa405

Article