Liu, L. et al. Global, regional, and national causes of under-5 mortality in 2000–15: an updated systematic analysis with implications for the Sustainable Development Goals. Lancet 388, 3027–3035 (2016).
Article PubMed PubMed Central Google Scholar
Ku, L. C., Boggess, K. A. & Cohen-Wolkowiez, M. Bacterial meningitis in infants. Clin. Perinatol. 42, 29–45 (2015).
Furyk, J. S., Swann, O. & Molyneux, E. Systematic review: neonatal meningitis in the developing world. Trop. Med Int Health 16, 672–679 (2011).
Article CAS PubMed Google Scholar
Cantey, J. B. & Milstone, A. M. Bloodstream infections: epidemiology and resistance. Clin. Perinatol. 42, 1–16 (2015).
Anderson, V., Anderson, P., Grimwood, K. & Nolan, T. Cognitive and executive function 12 years after childhood bacterial meningitis: Effect of acute neurologic complications and age of onset. J. Pediatr. Psychol. 29, 67–81 (2004).
Evans-Roberts, K. M. et al. DNA gyrase is the target for the quinolone drug ciprofloxacin in Arabidopsis thaliana. J. Biol. Chem. 291, 3136–3144 (2016).
Article CAS PubMed Google Scholar
Sharma, D. et al. Interplay of the quality of ciprofloxacin and antibiotic resistance in developing countries. Front Pharm. 8, 546 (2017).
Tebano, G. et al. Essential and forgotten antibiotics: An inventory in low- and middle-income countries. Int. J. Antimicrob. Agents 54, 273–282 (2019).
Article CAS PubMed Google Scholar
Nau, R., Sorgel, F. & Eiffert, H. Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections. Clin. Microbiol Rev. 23, 858–883 (2010).
Article CAS PubMed PubMed Central Google Scholar
Nau, R. et al. Penetration of ciprofloxacin into the cerebrospinal fluid of patients with uninflamed meninges. J. Antimicrob. Chemother. 25, 965–973 (1990).
Article CAS PubMed Google Scholar
Wolff, M. et al. Penetration of ciprofloxacin into cerebrospinal fluid of patients with bacterial meningitis. Antimicrob. Agents Chemother. 31, 899–902 (1987).
Article CAS PubMed PubMed Central Google Scholar
Lipman, J. et al. Ciprofloxacin pharmacokinetic profiles in paediatric sepsis: how much ciprofloxacin is enough? Intensive Care Med. 28, 493–500 (2002).
Article CAS PubMed Google Scholar
Rubio, T. T. et al. Pharmacokinetic disposition of sequential intravenous/oral ciprofloxacin in pediatric cystic fibrosis patients with acute pulmonary exacerbation. Pediatr. Infect. Dis. J. 16, 112–117 (1997).
Article CAS PubMed Google Scholar
Dr Veronica Zanichelli, McMaster University. 2021 WHO Expert Committee on Selection and Use of Essential Medicines 2021. Available from: https://cdn.who.int/media/docs/default-source/essential-medicines/2021-eml-expert-committee/applications-for-new-indications-for-existing-listed-medicines/i.6_ab-neonatal-meningitis.pdf?sfvrsn=db6508d6_5.
Chaudhari, S., Suryawanshi, P., Ambardekar, S., Chinchwadkar, M. & Kinare, A. Safety profile of ciprofloxacin used for neonatal septicemia. Indian Pediatr. 41, 1246–1251 (2004).
Dutta, S., Chowdhary, G., Kumar, P., Mukhopadhay, K. & Narang, A. Ciprofloxacin administration to very low birth weight babies has no effect on linear growth in infancy. J. Trop. Pediatr. 52, 103–106 (2006).
National Institute for Health and Care Excellance. Neonatal infection: antibiotics for prevention and treatment (2021). [Available from: https://www.nice.org.uk/guidance/ng195.
Zimmermann, P. & Curtis, N. Normal values for cerebrospinal fluid in neonates: A systematic review. Neonatology 118, 629–638 (2021).
Muchohi, S. N. et al. Determination of ciprofloxacin in human plasma using high-performance liquid chromatography coupled with fluorescence detection: application to a population pharmacokinetics study in children with severe malnutrition. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 879, 146–152 (2011).
Zhao, W. et al. Population pharmacokinetics of ciprofloxacin in neonates and young infants less than three months of age. Antimicrob. Agents Chemother. 58, 6572–6580 (2014).
Article PubMed PubMed Central Google Scholar
Baudry-Simner, P. J. et al. Mechanisms of reduced susceptibility to ciprofloxacin in Escherichia coli isolates from Canadian hospitals. Can. J. Infect. Dis. Med Microbiol 23, e60–e64 (2012).
Article PubMed PubMed Central Google Scholar
Aggarwal, P., Dutta, S., Garg, S. K. & Narang, A. Multiple dose pharmacokinetics of ciprofloxacin in preterm babies. Indian Pediatr. 41, 1001–1007 (2004).
Kaguelidou, F., Turner, M. A., Choonara, I. & Jacqz-Aigrain, E. Ciprofloxacin use in neonates: a systematic review of the literature. Pediatr. Infect. Dis. J. 30, e29–e37 (2011).
Hirt, D. et al. Population pharmacokinetics of intravenous and oral ciprofloxacin in children to optimize dosing regimens. Eur. J. Clin. Pharm. 77, 1687–1695 (2021).
Pea, F., Viale, P., Pavan, F. & Furlanut, M. Pharmacokinetic considerations for antimicrobial therapy in patients receiving renal replacement therapy. Clin. Pharmacokinet. 46, 997–1038 (2007).
Article CAS PubMed Google Scholar
Facchin, A. et al. Variability of ciprofloxacin pharmacokinetics in children: impact on dose range in sickle cell patients. J. Antimicrob. Chemother. 73, 3423–3429 (2018).
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