Karam O, Tucci M. Massive transfusion in children. Transfus Med Rev 2016; 30: 213–6. https://doi.org/10.1016/j.tmrv.2016.05.010

Article  PubMed  Google Scholar 

Bhananker SM, Ramamoorthy C, Geiduschek JM, et al. Anesthesia-related cardiac arrest in children: update from the pediatric perioperative cardiac arrest registry. Anesth Analg 2007; 105: 344–50. https://doi.org/10.1213/01.ane.0000268712.00756.dd

Article  PubMed  Google Scholar 

Livingston MH, Singh S, Merritt NH. Massive transfusion in paediatric and adolescent trauma patients: incidence, patient profile, and outcomes prior to a massive transfusion protocol. Injury 2014; 45: 1301–6. https://doi.org/10.1016/j.injury.2014.05.033

Article  PubMed  Google Scholar 

Como JJ, Dutton RP, Scalea TM, Edelman BB, Hess JR. Blood transfusion rates in the care of acute trauma. Transfusion 2004; 44: 809–13. https://doi.org/10.1111/j.1537-2995.2004.03409.x

Article  PubMed  Google Scholar 

Rossaint R, Afshari A, Bouillon B, et al. The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition. Crit Care 2023; 27: 80. https://doi.org/10.1186/s13054-023-04327-7

Article  PubMed  PubMed Central  Google Scholar 

Kamyszek RW, Leraas HJ, Reed C, et al. Massive transfusion in the pediatric population: a systematic review and summary of best-evidence practice strategies. J Trauma Acute Care Surg 2019; 86: 744–54. https://doi.org/10.1097/ta.0000000000002188

Article  PubMed  Google Scholar 

Callum JL, Yeh CH, Petrosoniak A, et al. A regional massive hemorrhage protocol developed through a modified Delphi technique. CMAJ Open 2019; 7: E546–61. https://doi.org/10.9778/cmajo.20190042

Article  PubMed  PubMed Central  Google Scholar 

Chin V, Cope S, Yeh CH, et al. Massive hemorrhage protocol survey: marked variability and absent in one-third of hospitals in Ontario, Canada. Injury 2019; 50: 46–53. https://doi.org/10.1016/j.injury.2018.11.026

Article  PubMed  Google Scholar 

Horst J, Leonard JC, Vogel A, Jacobs R, Spinella PC. A survey of US and Canadian hospitals’ paediatric massive transfusion protocol policies. Transfus Med 2016; 26: 49–56. https://doi.org/10.1111/tme.12277

Article  CAS  PubMed  Google Scholar 

Thomasson RR, Yazer MH, Gorham JD, et al. International assessment of massive transfusion protocol contents and indications for activation. Transfusion 2019; 59: 1637–43. https://doi.org/10.1111/trf.15149

Article  CAS  PubMed  Google Scholar 

Ontario Regional Blood Coordinating Network. Provincial MHP toolkit. Available from URL: https://transfusionontario.org/en/category/massive-hemorrhage-protocol/toolkit/ (accessed July 2023).

Maw G, Furyk C. Pediatric massive transfusion: a systematic review. Pediatr Emerg Care 2018; 34: 594–8. https://doi.org/10.1097/pec.0000000000001570

Article  PubMed  Google Scholar 

Evangelista ME, Gaffley M, Neff LP. Massive transfusion protocols for pediatric patients: current perspectives. J Blood Med 2020; 11: 163–72. https://doi.org/10.2147/jbm.s205132

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tan GM, Murto K, Downey LA, Wilder MS, Goobie SM. Error traps in Pediatric patient blood management in the perioperative period. Paediatr Anaesth 2023; 33: 609–19. https://doi.org/10.1111/pan.14683

Article  PubMed  Google Scholar 

Dillman DA. Mail and Internet Surveys: The Tailored Design Method, 2nd ed. Hoboken: John Wiley & Sons, Inc; 2000.

Google Scholar 

Leonard JC, Josephson CD, Luther JF, et al. Life-threatening bleeding in children: a prospective observational study. Crit Care Med 2021; 49: 1943–54. https://doi.org/10.1097/ccm.0000000000005075

Article  PubMed  PubMed Central  Google Scholar 

Cotton BA, Gunter OL, Isbell J, et al. Damage control hematology: the impact of a trauma exsanguination protocol on survival and blood product utilization. J Trauma 2008; 64: 1177–82. https://doi.org/10.1097/ta.0b013e31816c5c80

Article  PubMed  Google Scholar 

Cannon JW, Neff LP, Pidcoke HF, et al. The evolution of pediatric transfusion practice during combat operations 2001–2013. J Trauma Acute Care Surg 2018; 84: S69–76. https://doi.org/10.1097/ta.0000000000001869

Article  PubMed  Google Scholar 

Hardy JF, de Moerloose P, Samama CM, Members of the Group d'Intérêt en Hémostase Périopératoir. Massive transfusion and coagulopathy: pathophysiology and implications for clinical management. Can J Anesth 2004; 51: 293–310. https://doi.org/10.1007/bf03022251

Article  PubMed  Google Scholar 

Foster JC, Sappenfield JW, Smith RS, Kiley SP. Initiation and termination of massive transfusion protocols: current strategies and future prospects. Anesth Analg 2017; 125: 2045–55. https://doi.org/10.1213/ane.0000000000002436

Article  PubMed  Google Scholar 

Petrosoniak A, Pavenski K, da Luz LT, Callum J. Massive hemorrhage protocol: a practical approach to the bleeding trauma patient. Emerg Med Clin North Am 2023; 41: 51–69. https://doi.org/10.1016/j.emc.2022.09.010

Article  PubMed  Google Scholar 

Neff LP, Cannon JW, Morrison JJ, Edwards MJ, Spinella PC, Borgman MA. Clearly defining pediatric massive transfusion: cutting through the fog and friction with combat data. J Trauma Acute Care Surg 2015; 78: 22–9. https://doi.org/10.1097/ta.0000000000000488

Article  PubMed  Google Scholar 

Hanna K, Hamidi M, Anderson KT, et al. Pediatric resuscitation: weight-based packed red blood cell volume is a reliable predictor of mortality. J Trauma Acute Care Surg 2019; 87: 356–63. https://doi.org/10.1097/ta.0000000000002305

Article  PubMed  Google Scholar 

Rosenfeld E, Lau P, Zhang W, et al. Defining massive transfusion in civilian pediatric trauma. J Pediatr Surg 2019; 54: 975–9. https://doi.org/10.1016/j.jpedsurg.2019.01.029

Article  PubMed  Google Scholar 

Moren AM, Hamptom D, Diggs B, et al. Recursive partitioning identifies greater than 4 U of packed red blood cells per hour as an improved massive transfusion definition. J Trauma Acute Care Surg 2015; 79: 920–4. https://doi.org/10.1097/ta.0000000000000830

Article  PubMed  PubMed Central  Google Scholar 

Meyer DE, Cotton BA, Fox EE, et al. A comparison of resuscitation intensity and critical administration threshold in predicting early mortality among bleeding patients: a multicenter validation in 680 major transfusion patients. J Trauma Acute Care Surg 2018; 85: 691–6. https://doi.org/10.1097/ta.0000000000002020

Article  PubMed  PubMed Central  Google Scholar 

Avarello JT, Cantor RM. Pediatric major trauma: an approach to evaluation and management. Emerg Med Clin North Am 2007; 25: 803–36. https://doi.org/10.1016/j.emc.2007.06.013

Article  PubMed  Google Scholar 

Nystrup KB, Stensballe J, Bøttger M, Johansson PI, Ostrowski SR. Transfusion therapy in paediatric trauma patients: a review of the literature. Scand J Trauma Resusc Emerg Med 2015; 23: 21. https://doi.org/10.1186/s13049-015-0097-z

Article  PubMed  PubMed Central  Google Scholar 

Leeper CM, McKenna C, Gaines BA. Too little too late: hypotension and blood transfusion in the trauma bay are independent predictors of death in injured children. J Trauma Acute Care Surg 2018; 85: 674–8. https://doi.org/10.1097/ta.0000000000001823

Article  PubMed  Google Scholar 

Galvagno SM Jr, Nahmias JT, Young DA. Advanced Trauma Life Support® update 2019: management and applications for adults and special populations. Anesthesiol Clin 2019; 37: 13–32. https://doi.org/10.1016/j.anclin.2018.09.009

Article  PubMed  Google Scholar 

Phillips R, Acker SN, Shahi N, et al. The ABC-D score improves the sensitivity in predicting need for massive transfusion in pediatric trauma patients. J Pediatr Surg 2020; 55: 331–4. https://doi.org/10.1016/j.jpedsurg.2019.10.008

Article  PubMed  Google Scholar 

Borgman MA, Maegele M, Wade CE, Blackbourne LH, Spinella PC. Pediatric trauma BIG score: predicting mortality in children after military and civilian trauma. Pediatrics 2011; 127: e892–7. https://doi.org/10.1542/peds.2010-2439

Article  PubMed  Google Scholar 

Bjerkvig CK, Strandenes G, Eliassen HS, et al. “Blood failure” time to view blood as an organ: how oxygen debt contributes to blood failure and its implications for remote damage control resuscitation. Transfusion 2016; 56: S182–9. https://doi.org/10.1111/trf.13500

Article  CAS  PubMed  Google Scholar 

Valentine SL, Bembea MM, Muszynski JA, et al. Consensus recommendations for red blood cell transfusion practice in critically ill children from the pediatric critical care transfusion and anemia expertise initiative. Pediatr Crit Care Med 2018; 19: 884–98. https://doi.org/10.1097/pcc.0000000000001613

Article  PubMed  PubMed Central  Google Scholar 

Tucci M, Crighton G, Goobie SM, et al. Plasma and platelet transfusion strategies in critically ill children following noncardiac surgery and critically ill children undergoing invasive procedures outside the operating room: from the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med 2022; 23: E50–62. https://doi.org/10.1097/pcc.0000000000002858

Article  PubMed  PubMed Central  Google Scholar 

Russell R, Bauer DF, Goobie SM, et al. Plasma and platelet transfusion strategies in critically ill children following severe trauma, traumatic brain injury, and/or intracranial hemorrhage: from the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med 2022; 23: E14–24. https://doi.org/10.1097/pcc.0000000000002855

Article  PubMed  PubMed Central