This study was funded by Chi Mei Medical Center (grant No. 111CM-KMU-09), Kaohsiung Medical University Research Foundation (NCTUKMU108-BIO-02), Kaohsiung Medical University Chung-Ho Memorial Hospital (KMUH SI11010) and the National Science and Technology Council (grant No. MOST 110-2314-B-037-055 and MOST 111-2314-B-037-034-MY2).