The pretreatment of samples was vital for enhancing the sensitivity and accuracy of analytical methods. An efficient and sensitive method, based on modified QuEChERS with high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) for the simultaneous determination of 13 sulfonamides (SAs) in soil, was developed. After extraction by sonication with methanol, clean-up procedure was achieved by QuEChERS with primary secondary amine (PSA). Quantification of 13 SAs was performed by HPLC-MS/MS in electrospray ionization (ESI) and multi reaction monitor (MRM). Under optimized condition, the standard solution exhibited good linearity within the range of 0.01-0.5 μg/mL. The limits of detection and the limits of quantification of the developed method were 0.007-0.030 μg/kg and 0.022-0.101 μg/kg, respectively. The spiked recoveries for 13 SAs were in the range of 74.5-111.7% with RSD less than 15%. Furthermore, the developed method was successfully applied for the determination of SAs in real soil samples. The above results showed that the proposed method would be a choice analytical method for SAs in environmental ecological research.

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