Harnessing the Potential of CD40 Agonism in Cancer Therapy

Dr. Chi Yan is an Assistant Professor in the Department of Pharmacology at Vanderbilt University School of Medicine, Nashville, TN, USA. He obtained his Ph.D. in Cancer Immunology from Dalhousie University, Canada, and his M.Sc. in Molecular Biology and Bioinformatics from Saint Mary’s University, Canada. Dr. Yan is a recipient of the prestigious Graduate Fellowship from CRTP-BHCRI in Cancer Research at CIHR, Canada, and the Graduate Fellowship from IWK Health Center, Canada. The goal of Dr. Yan’s research program is to better understand the interaction between tumor cells and immune cells so that one can improve current therapeutic strategies for the treatment of melanoma and breast cancer patients. Dr. Yan’s ongoing research at Vanderbilt University aims to enhance antitumor immune responses by combining personalized targeted and immune therapies. As an accomplished young scientist, Dr. Yan’s work has resulted in investigator-initiated clinical trial NCT05764395 and over 30 publications, including 24 first- or senior-authored articles, in highly-ranked journals that are considered among the top in the field, e.g., Cytokine & Growth Factor Reviews (2024), Molecular Cancer (June 2021, Nov 2021, and 2023), Cancers (2023), npj Precision Oncology (2022), Cancer Immunology Research (2021), and Journal of Clinical Investigation (2020) etc. In addition, Dr. Yan has peer-reviewed over 60 manuscripts for biomedical science journals, including but not limited to the prestigious Nature, Molecular Cancer, Journal of Clinical Investigation, Clinical Cancer Research, and Cancer Research etc. Dr. Yan has also served as Review Editor for Frontiers in Immunology, Frontiers in Oncology, Frontiers in Cell and Developmental Biology, and Frontiers in Pharmacology. Dr. Yan was invited to present his research work at local, national, and international conferences, including Innovation in Breast Cancer Symposium 2022 (Madrid, Spain & Virtual) and the AAI Annual Meeting - IMMUNOLOGY2022 with the awarded AAI Early Career Faculty Travel Grant, etc. Dr. Yan has recently been selected as the Vanderbilt University Early-Career Scientist nominee for the global 2024 Takeda Innovators in Science Award - Cancer Immunology. Dr. Yan received a Henry J Lloyd Foundation Melanoma Research Career Development Grant (PI), Vanderbilt-Ingram Cancer Center Support Grant (Co-PI), and is actively managing and serving as the Co-PI of two ongoing NIH R01 grants (CA116021 and CA243326). Dr. Yan served as the direct mentor of Yang Zhou (first author), and is the corresponding author of the published review in Cytokine & Growth Factor Reviews (2024).

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