Richters A, Aben KKH, Kiemeney L. The global burden of urinary bladder cancer: an update. World J Urol. 2020;38(8):1895–904. https://doi.org/10.1007/s00345-019-02984-4.

Article  PubMed  Google Scholar 

Sanli O, Dobruch J, Knowles MA, Burger M, Alemozaffar M, Nielsen ME, et al. Bladder cancer. Nat Rev Dis Primers. 2017;3:17022. https://doi.org/10.1038/nrdp.2017.22.

Article  PubMed  Google Scholar 

Cambier S, Sylvester RJ, Collette L, Gontero P, Brausi MA, van Andel G, et al. EORTC nomograms and risk groups for predicting recurrence, progression, and disease-specific and overall survival in non-muscle-invasive stage Ta-T1 urothelial bladder cancer patients treated with 1–3 years of maintenance bacillus calmette-guerin. Eur Urol. 2016;69(1):60–9. https://doi.org/10.1016/j.eururo.2015.06.045.

Article  PubMed  Google Scholar 

Wilson F, Joseph N, Choudhury A. Biomarkers in muscle invasive bladder cancer. Adv Clin Chem. 2022;107:265–97. https://doi.org/10.1016/bs.acc.2021.07.005.

Article  PubMed  Google Scholar 

Chen S, Gu J, Zhang Q, Hu Y, Ge Y. Development of biomarker signatures associated with anoikis to predict prognosis in endometrial carcinoma patients. J Oncol. 2021;2021:3375297. https://doi.org/10.1155/2021/3375297.

Article  PubMed  PubMed Central  Google Scholar 

Adeshakin FO, Adeshakin AO, Afolabi LO, Yan D, Zhang G, Wan X. Mechanisms for modulating anoikis resistance in cancer and the relevance of metabolic reprogramming. Front Oncol. 2021;11:626577. https://doi.org/10.3389/fonc.2021.626577.

Article  PubMed  PubMed Central  Google Scholar 

Du S, Yang Z, Lu X, Yousuf S, Zhao M, Li W, et al. Anoikis resistant gastric cancer cells promote angiogenesis and peritoneal metastasis through C/EBPbeta-mediated PDGFB autocrine and paracrine signaling. Oncogene. 2021;40(38):5764–79. https://doi.org/10.1038/s41388-021-01988-y.

Article  PubMed  Google Scholar 

Zhu Z, Fang C, Xu H, Yuan L, Du Y, Ni Y, et al. Anoikis resistance in diffuse glioma: the potential therapeutic targets in the future. Front Oncol. 2022;12:976557. https://doi.org/10.3389/fonc.2022.976557.

Article  PubMed  PubMed Central  Google Scholar 

Lee HY, Son SW, Moeng S, Choi SY, Park JK. The role of noncoding RNAs in the regulation of anoikis and anchorage-independent growth in cancer. Int J Mol Sci. 2021;22(2). https://doi.org/10.3390/ijms22020627.

Ziegenhain C, Vieth B, Parekh S, Reinius B, Guillaumet-Adkins A, Smets M, et al. Comparative analysis of single-cell RNA sequencing methods. Mol Cell. 2017;65(4):631-643 e634. https://doi.org/10.1016/j.molcel.2017.01.023.

Article  PubMed  Google Scholar 

Kolodziejczyk AA, Kim JK, Svensson V, Marioni JC, Teichmann SA. The technology and biology of single-cell RNA sequencing. Mol Cell. 2015;58(4):610–20. https://doi.org/10.1016/j.molcel.2015.04.005.

Article  PubMed  Google Scholar 

Jovic D, Liang X, Zeng H, Lin L, Xu F, Luo Y. Single-cell RNA sequencing technologies and applications: a brief overview. Clin Transl Med. 2022;12(3):e694. https://doi.org/10.1002/ctm2.694.

Article  PubMed  PubMed Central  Google Scholar 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, et al. Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47. https://doi.org/10.1093/nar/gkv007.

Article  PubMed  PubMed Central  Google Scholar 

Leek JT, Johnson WE, Parker HS, Jaffe AE, Storey JD. The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics. 2012;28(6):882–3. https://doi.org/10.1093/bioinformatics/bts034.

Article  PubMed  PubMed Central  Google Scholar 

Zhang H, Meltzer P, Davis S. RCircos: an R package for Circos 2D track plots. BMC Bioinformatics. 2013;14:244. https://doi.org/10.1186/1471-2105-14-244.

Article  PubMed  PubMed Central  Google Scholar 

Jolliffe IT, Cadima J. Principal component analysis: a review and recent developments. Philos Trans A Math Phys Eng Sci. 2016;374(2065):20150202. https://doi.org/10.1098/rsta.2015.0202.

Article  PubMed  PubMed Central  Google Scholar 

Pezzotti N, Lelieveldt BPF, Van Der Maaten L, Hollt T, Eisemann E, Vilanova A. Approximated and user steerable tSNE for progressive visual analytics. IEEE Trans Vis Comput Graph. 2017;23(7):1739–52. https://doi.org/10.1109/TVCG.2016.2570755.

Article  PubMed  Google Scholar 

Armstrong G, Martino C, Rahman G, Gonzalez A, Vazquez-Baeza Y, Mishne G, et al. Uniform manifold approximation and projection (UMAP) reveals composite patterns and resolves visualization artifacts in microbiome data. mSystems. 2021;6(5):e0069121. https://doi.org/10.1128/mSystems.00691-21.

Article  PubMed  Google Scholar 

Zhao Z, Liu H, Zhou X, Fang D, Ou X, Ye J, et al. Necroptosis-related lncRNAs: predicting prognosis and the distinction between the cold and hot tumors in gastric cancer. J Oncol. 2021;2021:6718443. https://doi.org/10.1155/2021/6718443.

Article  PubMed  PubMed Central  Google Scholar 

Meng T, Huang R, Zeng Z, Huang Z, Yin H, Jiao C, et al. Identification of prognostic and metastatic alternative splicing signatures in kidney renal clear cell carcinoma. Front Bioeng Biotechnol. 2019;7:270. https://doi.org/10.3389/fbioe.2019.00270.

Article  PubMed  PubMed Central  Google Scholar 

Yoshihara K, Shahmoradgoli M, Martinez E, Vegesna R, Kim H, Torres-Garcia W, et al. Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun. 2013;4:2612. https://doi.org/10.1038/ncomms3612.

Article  PubMed  Google Scholar 

Newman AM, Liu CL, Green MR, Gentles AJ, Feng W, Xu Y, et al. Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 2015;12(5):453–7. https://doi.org/10.1038/nmeth.3337.

Article  PubMed  PubMed Central  Google Scholar 

Han Y, Wang Y, Dong X, Sun D, Liu Z, Yue J, et al. TISCH2: expanded datasets and new tools for single-cell transcriptome analyses of the tumor microenvironment. Nucleic Acids Res. 2023;51(D1):D1425–31. https://doi.org/10.1093/nar/gkac959.

Article  PubMed  Google Scholar 

Paoli P, Giannoni E, Chiarugi P. Anoikis molecular pathways and its role in cancer progression. Biochim Biophys Acta. 2013;1833(12):3481–98. https://doi.org/10.1016/j.bbamcr.2013.06.026.

Article  PubMed  Google Scholar 

Taddei ML, Giannoni E, Fiaschi T, Chiarugi P. Anoikis: an emerging hallmark in health and diseases. J Pathol. 2012;226(2):380–93. https://doi.org/10.1002/path.3000.

Article  PubMed  Google Scholar 

Zhang H, Wang G, Zhou R, Li X, Sun Y, Li Y, et al. SPIB promotes anoikis resistance via elevated autolysosomal process in lung cancer cells. FEBS J. 2020;287(21):4696–709. https://doi.org/10.1111/febs.15272.

Article  PubMed  Google Scholar 

Valentijn AJ, Zouq N, Gilmore AP. Anoikis. Biochem Soc Trans. 2004;32(Pt3):421–5. https://doi.org/10.1042/BST0320421.

Article  PubMed  Google Scholar 

Zhi Z, Ouyang Z, Ren Y, Cheng Y, Liu P, Wen Y, et al. Non-canonical phosphorylation of Bmf by p38 MAPK promotes its apoptotic activity in anoikis. Cell Death Differ. 2022;29(2):323–36. https://doi.org/10.1038/s41418-021-00855-3.

Article  PubMed  Google Scholar 

Jin L, Chun J, Pan C, Alesi GN, Li D, Magliocca KR, et al. Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis. Oncogene. 2017;36(27):3797–806. https://doi.org/10.1038/onc.2017.6.

Article  PubMed  PubMed Central  Google Scholar 

Xu R, Yan Y, Zheng X, Zhang H, Chen W, Li H, et al. Aspirin suppresses breast cancer metastasis to lung by targeting anoikis resistance. Carcinogenesis. 2022;43(2):104–14. https://doi.org/10.1093/carcin/bgab117.

Article  PubMed  Google Scholar 

Frankel A, Rosen K, Filmus J, Kerbel RS. Induction of anoikis and suppression of human ovarian tumor growth in vivo by down-regulation of Bcl-X(L). Cancer Res. 2001;61(12):4837–41.

PubMed  Google Scholar 

Toricelli M, Melo FH, Peres GB, Silva DC, Jasiulionis MG. Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation. Mol Cancer. 2013;12:22. https://doi.org/10.1186/1476-4598-12-22.

Article  PubMed  PubMed Central  Google Scholar 

Markouli M, Strepkos D, Basdra EK, Papavassiliou AG, Piperi C. Prominent Role of Histone Modifications in the Regulation of Tumor Metastasis. Int J Mol Sci. 2021;22(5). https://doi.org/10.3390/ijms22052778.

Lu Q, Wang L, Gao Y, Zhu P, Li L, Wang X, et al. lncRNA APOC1P1–3 promoting anoikis-resistance of breast cancer cells. Cancer Cell Int. 2021;21(1):232. https://doi.org/10.1186/s12935-021-01916-w.

Article  PubMed  PubMed Central  Google Scholar 

Egan CE, Stefanova D, Ahmed A, Raja VJ, Thiesmeyer JW, Chen KJ, et al. CSPG4 is a potential therapeutic target in anaplastic thyroid cancer. Thyroid. 2021;31(10):1481–93. https://doi.org/10.1089/thy.2021.0067.

Article  PubMed  PubMed Central  Google Scholar 

Kim HY, Han Y, Jang JH, Jung CW, Kim SH, Kim HJ. Effects of CALR-Mutant type and burden on the phenotype of myeloproliferative neoplasms. Diagnostics (Basel).2022;12(11). https://doi.org/10.3390/diagnostics12112570.

Olschok K, Han L, de Toledo MAS, Bohnke J, Grasshoff M, Costa IG, et al. CALR frameshift mutations in MPN patient-derived iPSCs accelerate maturation of megakaryocytes. Stem Cell Rep. 2021;16(11):2768–83. https://doi.org/10.1016/j.stemcr.2021.09.019.

Article  Google Scholar 

Liu R, Li R, Yu H, Liu J, Zheng S, Li Y, et al. NTF3 correlates with prognosis and immune infiltration in hepatocellular carcinoma. Front Med (Lausanne). 2021;8:795849. https://doi.org/10.3389/fmed.2021.795849.