Document Type : Short Communication

Authors

1 Saiful Anwar Hospital, Malang, Indonesia

2 Department of Clinical Pathology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia

Abstract

Introduction: Lymphoma is the third most common neoplasm, especially in the head and neck area. Malignant lymphoma is divided into Hodgkin's (HL) and non-Hodgkin's Lymphoma (NHL). Lymphoma, especially NHL, can occur in extra nodes, especially gastrointestinal (GI) lymphoma. Although gastrointestinal lymphoma is the most common extranodal NHL, primary colonic NHL has a very low incidence. Hepatitis C virus (HCV) can cause disturbances in the liver and the extra liver, and the most common extra liver is NHL. Secondary Autoimmune Hemolytic Anemia (AIHA) may occur in patients with lymphoproliferative disorders. Case: A 47-year-old man presented with abdominal pain, jaundice, and weight loss. Laboratory examinations showed anemia, hyperbilirubinemia (direct and indirect), elevated aspartate transaminase (AST), alanine transaminase (ALT), and lactate dehydrogenase (LDH), reactive anti-HCV, and positive HCV RNA. The biopsy results support a B-cell NHL. In addition, imaging showed multiple intra-abdominal lymphadenopathies. Conclusion: The patient, was diagnosed with B-cell colon NHL, possibly primarily based on clinical symptoms and biopsy. NHL in this patient can be caused by HCV infection. In addition, AIHA experienced in these patients can be caused by lymphoproliferative disorders, namely NHL.

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