Dual RNase activity of IRE1 as a target for anticancer therapies

Allagnat F, Christulia F, Ortis F, Pirot P, Lortz S, Lenzen S et al (2010) Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis. Diabetologia 53(6):1120–1130

Article  CAS  PubMed  Google Scholar 

Almanza A, Carlesso A, Chintha C, Creedican S, Doultsinos D, Leuzzi B et al (2019) Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications. Febs J 286(2):241–278

Article  CAS  PubMed  Google Scholar 

Alrasheed M, Alsuhibani A, Hincapie AL, Guo JF (2021) Safety evaluation of panobinostat, ixazomib, elotuzumab, and daratumumab using FDA adverse event reporting system (FAERS) database 2015–2020. Pharmacoepidem Dr S 30:333

Google Scholar 

Alves-Fernandes DK, Oliveira EA, Faiao-Flores F, Alicea-Rebecca G, Weeraratna AT, Smalley KSM et al (2019) ER stress promotes antitumor effects in BRAFi/MEKi resistant human melanoma induced by natural compound 4-nerolidylcathecol (4-NC). Pharmacol Res 141:63–72

Article  CAS  PubMed  Google Scholar 

Atkins C, Liu Q, Minthorn E, Zhang SY, Figueroa DJ, Moss K et al (2013) Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res 73(6):1993–2002

Article  CAS  PubMed  Google Scholar 

Auner HW, Moody AM, Ward TH, Kraus M, Milan E, May P et al (2013) Combined inhibition of p97 and the proteasome causes lethal disruption of the secretory apparatus in multiple myeloma cells. PLoS ONE 8(9):e74415

Article  CAS  PubMed  PubMed Central  Google Scholar 

Avril T, Chevet E (2020) IRE1-mediated miRNA maturation in macrophage phosphoinositide signaling. Embo Rep 21(12):e51929

Article  CAS  PubMed  PubMed Central  Google Scholar 

Babour A, Bicknell AA, Tourtellotte J, Niwa M (2010) A surveillance pathway monitors the fitness of the endoplasmic reticulum to control its inheritance. Cell 142(2):256–269

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baird TD, Wek RC (2012) Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism. Adv Nutr 3(3):307–321

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baker BM, Nargund AM, Sun T, Haynes CM (2012) Protective coupling of mitochondrial function and protein synthesis via the eIF2alpha kinase GCN-2. Plos Genet 8(6):e1002760

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balkwill FR, Capasso M, Hagemann T (2012) The tumor microenvironment at a glance. J Cell Sci 125(Pt 23):5591–5596

Article  CAS  PubMed  Google Scholar 

Balsas P, Galan-Malo P, Marzo I, Naval J (2012) Bortezomib resistance in a myeloma cell line is associated to PSMbeta5 overexpression and polyploidy. Leuk Res 36(2):212–218

Article  CAS  PubMed  Google Scholar 

Bartoszewska S, Kochan K, Madanecki P, Piotrowski A, Ochocka R, Collawn JF et al (2013) Regulation of the unfolded protein response by microRNAs. Cell Mol Biol Lett 18(4):555–578

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bartoszewska S, Kamysz W, Jakiela B, Sanak M, Kroliczewski J, Bebok Z et al (2017) miR-200b downregulates CFTR during hypoxia in human lung epithelial cells. Cell Mol Biol Lett 22:23

Article  PubMed  PubMed Central  Google Scholar 

Bartoszewska S, Cabaj A, Dabrowski M, Collawn JF, Bartoszewski R (2019) miR-34c-5p modulates X-box-binding protein 1 (XBP1) expression during the adaptive phase of the unfolded protein response. Faseb J 33(10):11541–11554

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bartoszewska S, Kroliczewski J, Crossman DK, Pogorzelska A, Baginski M, Collawn JF et al (2021) Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1alpha endoribonuclease inhibitor. Cell Mol Biol Lett 26(1):11

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bartoszewska S, Collawn JF, Bartoszewski R (2022) The role of the hypoxia-related unfolded protein response (UPR) in the tumor microenvironment. Cancers 14(19):4870

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bartoszewski R, Brewer JW, Rab A, Crossman DK, Bartoszewska S, Kapoor N et al (2011) The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes. J Biol Chem 286(48):41862–41870

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bartoszewski R, Kroliczewski J, Piotrowski A, Jasiecka AJ, Bartoszewska S, Vecchio-Pagan B et al (2016) Codon bias and the folding dynamics of the cystic fibrosis transmembrane conductance regulator. Cell Mol Biol Lett 21:23

Article  PubMed  PubMed Central  Google Scholar 

Bertolotti A, Wang X, Novoa I, Jungreis R, Schlessinger K, Cho JH et al (2001) Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice. J Clin Invest 107(5):585–593

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bi M, Naczki C, Koritzinsky M, Fels D, Blais J, Hu N et al (2005) ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. Embo J 24(19):3470–3481

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blais J, Bell JC (2006) Novel therapeutic target: the PERKs of inhibiting the integrated stress response. Cell Cycle 5(24):2874–2877

Article  CAS  PubMed  Google Scholar 

Bottcher JP, Sousa CR (2018) The role of type 1 conventional dendritic cells in cancer immunity. Trends Cancer 4(11):784–792

Article  PubMed  PubMed Central  Google Scholar 

Bravo R, Parra V, Gatica D, Rodriguez AE, Torrealba N, Paredes F et al (2013) Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration. Int Rev Cell Mol Biol 301:215–290

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bross PF, Kane R, Farrell AT, Abraham S, Benson K, Brower ME et al (2004) Approval summary for bortezomib for injection in the treatment of multiple myeloma. Clin Cancer Res 10(12 Pt 1):3954–3964

Article  CAS  PubMed  Google Scholar 

Byrd A, Brewer J (2011) MicroRNA-mediated repression of XBP1: a novel mechanism for regulation of a UPR transcriptional activator. J Immunol 186:62

Article  Google Scholar 

Byrd AE, Brewer JW (2013) Micro(RNA)managing endoplasmic reticulum stress. IUBMB Life 65(5):373–381

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cabral-Miranda F, Tamburini G, Martinez G, Ardiles AO, Medinas DB, Gerakis Y et al (2022) Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging. Embo J 41(22):e111952

Article  CAS  PubMed  Google Scholar 

Calabrese EJ, Bachmann KA, Bailer AJ, Bolger PM, Borak J, Cai L et al (2007) Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicol Appl Pharmacol 222(1):122–128

Article  CAS  PubMed  Google Scholar 

Calfon M, Zeng HQ, Urano F, Till JH, Hubbard SR, Harding HP et al (2002) IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 420(6912):202

Article  CAS  Google Scholar 

Carlesso A, Chintha C, Gorman AM, Samali A, Eriksson LA (2018) Binding analysis of the inositol-requiring enzyme 1 kinase domain. ACS Omega 3(10):13313–13322

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carlesso A, Chintha C, Gorman AM, Samali A, Eriksson LA (2019) Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1 inhibitors. Sci Rep 9(1):3407

Article  PubMed  PubMed Central  Google Scholar 

Carlesso A, Horberg J, Reymer A, Eriksson LA (2020) New insights on human IRE1 tetramer structures based on molecular modeling. Sci Rep 10(1):17490

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carrara M, Prischi F, Nowak PR, Ali MM (2015) Crystal structures reveal transient PERK luminal domain tetramerization in endoplasmic reticulum stress signaling. Embo J 34(11):1589–1600

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cevatemre B, Erkisa M, Aztopal N, Karakas D, Alper P, Tsimplouli C et al (2018) A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer. Pharmacol Res 129:500–514

Article  CAS 

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