Pharmacotherapy for Traumatic Brain Injury: The Next Generation of Clinical Trials

Marklund N, Bakshi A, Castelbuono DJ, Conte V, McIntosh TK. Evaluation of pharmacological treatment strategies in traumatic brain injury. Curr Pharm Des. 2006;12:1645–80.

Article  CAS  PubMed  Google Scholar 

Narayan RK, Michel ME, Ansell BJ, et al. Clinical trials in head injury. J Neurotrauma. 2002;19:503–57.

Article  PubMed  Google Scholar 

Maas AI, Murray G, Henney H III, et al. Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial. Lancet Neurol. 2006;5:38–45.

Article  CAS  PubMed  Google Scholar 

Temkin NR, Anderson GD, Winn HR, et al. Magnesium sulfate for neuroprotection after traumatic brain injury: a randomised controlled trial. Lancet Neurol. 2007;6:29–38.

Article  CAS  PubMed  Google Scholar 

Zafonte RD, Bagiella E, Ansel BM, et al. Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: citicoline brain injury treatment trial (COBRIT). JAMA. 2012;308:1993–2000.

Article  CAS  PubMed  Google Scholar 

Wright DW, Yeatts SD, Silbergleit R, et al. Very early administration of progesterone for acute traumatic brain injury. N Engl J Med. 2014;371:2457–66.

Article  PubMed  PubMed Central  Google Scholar 

Nichol A, French C, Little L, et al. Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial. Lancet. 2015;386:2499–506.

Article  CAS  PubMed  Google Scholar 

Saatman KE, Duhaime AC, Bullock R, Maas AI, Valadka A, Manley GT. Classification of traumatic brain injury for targeted therapies. J Neurotrauma. 2008;25:719–38.

Article  PubMed  PubMed Central  Google Scholar 

Maas AIR, Menon DK, Adelson PD, et al. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. Lancet Neurol. 2017;16:987–1048.

Article  PubMed  Google Scholar 

Maas AIR, Menon DK, Manley GT, et al. Traumatic brain injury: progress and challenges in prevention, clinical care, and research. Lancet Neurol. 2022;21:1004–60.

Article  PubMed  Google Scholar 

Hawryluk GWJ, Aguilera S, Buki A, et al. A management algorithm for patients with intracranial pressure monitoring: the Seattle international severe traumatic brain injury consensus conference (SIBICC). Intensive Care Med. 2019;45:1783–94.

Article  PubMed  PubMed Central  Google Scholar 

Kochanek PM, Tasker RC, Bell MJ, et al. Management of pediatric severe traumatic brain injury: 2019 consensus and guidelines-based algorithm for first and second tier therapies. Pediatr Crit Care Med. 2019;20:269–79.

Article  PubMed  Google Scholar 

Silverberg ND, Iaccarino MA, Panenka WJ, et al. Management of concussion and mild traumatic brain injury: a synthesis of practice guidelines. American Congress of Rehabilitation Medicine Brain Injury Interdisciplinary Special Interest Group Mild TBI Task Force. Arch Phys Med Rehabil. 2020;101:382–393.

Radabaugh HL, Ferguson AR, Bramlett HM, Dietrich WD. Increasing rigor of preclinical research to maximize opportunities for translation. Neurotherapeutics. 2023. https://doi.org/10.1007/s13311-023-01400-5. Online ahead of print.

Monsour M, Lee JY, Borlongan CV. An understated comorbidity: the impact of homelessness on traumatic brain injury. Neurotherapeutics. 2023. https://doi.org/10.1007/s13311-023-01419-8. Online ahead of print.

Lazaridis C, Foreman B. Management strategies based on multi-modality neuromonitoring in severe traumatic brain injury. Neurotherapeutics. 2023. https://doi.org/10.1007/s13311-023-01411-2. Online ahead of print.

Jha RM, Kochanek PM, Simard JM. Pathophysiology and treatment of cerebral edema in traumatic brain injury. Neuropharmacology. 2019;145:230–46.

Article  CAS  PubMed  Google Scholar 

Smith CA, Carpenter KL, Hutchinson PJ, Smielewski P, Helmy A. Candidate neuroinflammatory markers of cerebral autoregulation dysfunction in human acute brain injury. J Cereb Blood Flow Metab. 2023;43:1237–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jha RM, Simard JM. Glibenclamide for brain contusions: contextualizing a promising clinical trial design that leverages an imaging-based TBI endotype. Neurotherapeutics. 2023. https://doi.org/10.1007/s13311-023-01389-x. Online ahead of print.

Hansson MJ, Elmér E. Cyclosporine as therapy for traumatic brain injury. Neurotherapeutics. 2023. https://doi.org/10.1007/s13311-023-01414-z. Online ahead of print.

Laskowitz DT, Van Wyck DW. ApoE mimetic peptides as therapy for traumatic brain injury. Neurotherapeutics. 2023. https://doi.org/10.1007/s13311-023-01413-0. Online ahead of print.

Lindblad C, Rostami E, Helmy A. Interleukin-1 receptor antagonist as therapy for traumatic brain injury. Neurotherapeutics. 2023. https://doi.org/10.1007/s13311-023-01421-0. Online ahead of print.

Clark RSB, Empey PE, Kochanek PM, Bell MJ. N-acetylcysteine and probenecid adjuvant therapy for traumatic brain injury. Neurotherapeutics. 2023. https://doi.org/10.1007/s13311-023-01422-z. Online ahead of print.

Katlowitz K, Gopinath S, Cruz Navarro J, Robertson C. HMG-CoA reductase inhibitors for traumatic brain injury. Neurotherapeutics. 2023. https://doi.org/10.1007/s13311-023-01399-9. Online ahead of print.

Bergold P, Furhang R, Lawless S. Treating traumatic brain injury with minocycline. Neurotherapeutics. 2023.

Villapol S, Janatpour ZC, Affram KO, Symes AJ. The renin angiotensin system as a therapeutic target in traumatic brain injury. Neurotherapeutics. 2023.

Baudry M, Luo YL, Bi X. Calpain-2 inhibitors as therapy of traumatic brain injury. Neurotherapeutics. 2023. https://doi.org/10.1007/s13311-023-01407-y. Online ahead of print.

Verdoorn TA, Parry TJ, Pinna G, Lifshitz J. Neurosteroid receptor modulators for treating traumatic brain injury. Neurotherapeutics. 2023. https://doi.org/10.1007/s13311-023-01428-7. Online ahead of print.

Henry RJ, Ritzel RM, Barrett JP, et al. Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits. J Neurosci. 2020;40:2960–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J, Lu Y, Carr C, Dhandapani KM, Brann DW. Senolytic therapy is neuroprotective and improves functional outcome long-term after traumatic brain injury in mice. Front Neurosci. 2023;17:1227705.

Article  PubMed  PubMed Central  Google Scholar 

Sridharan PS, Miller E, Pieper AA. Application of P7C3 compounds to investigating and treating acute and chronic traumatic brain injury. Neurotherapeutics. 2023. https://doi.org/10.1007/s13311-023-01427-8. Online ahead of print.

Kalyani P, Amyot F, Lippa SM, Werner JK, Kenney K, Diaz-Arrastia R. Phosphodiesterase-5 (PDE-5) inhibitors as therapy for cerebrovascular dysfunction in chronic traumatic brain injury. Neurotherapeutics. 2023.

Hartings JA, Dreier JP, Ngwenya LB, Balu R, Carlson AP, Foreman B. Improving neurotrauma by depolarization inhibition with combination therapy: a phase 2 randomized feasibility trial. Neurosurgery. 2023. https://doi.org/10.1227/neu.0000000000002509. Online ahead of print.

Kenny EM, Fidan E, Yang Q, et al. Ferroptosis contributes to neuronal death and functional outcome after traumatic brain injury. Crit Care Med. 2019;47:410–8.

Article  PubMed  PubMed Central  Google Scholar 

Gruen DS, Guyette FX, Brown JB, et al. Association of prehospital plasma with survival in patients with traumatic brain injury: a secondary analysis of the PAMPer cluster randomized clinical trial. JAMA Netw Open. 2020;3:e2016869.

Article  PubMed  PubMed Central  Google Scholar 

Opeyemi OM, Rogers MB, Firek BA, et al. Sustained dysbiosis and decreased short chain fatty acids after traumatic brain injury and impact on neurologic outcome. J Neurotrauma. 2021;38:2610–21.

Article  PubMed  PubMed Central  Google Scholar 

Xiong Y, Mahmood A, Chopp M. Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for traumatic brain injury via neuroprotection and neurorestoration. Neural Regen Res. 2024;19:49–54.

Article  PubMed  Google Scholar 

Sharma R, Kambhampati SP, Zhang Z, et al. Dendrimer mediated targeted delivery of sinomenine for the treatment of acute neuroinflammation in traumatic brain injury. J Control Release. 2020;323:361–75.

Article  CAS  PubMed  Google Scholar 

Kondo A, Shahpasand K, Mannix R, et al. Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy. Nature. 2015;523:431–6.

Article  PubMed  PubMed Central  Google Scholar 

Kawabori M, Chida D, Nejadnik B, Stonehouse AH, Okonkwo DO. Cell therapies for acute and chronic traumatic brain injury. Curr Med Res Opin. 2022;38:2183–9.

Article  CAS  PubMed  Google Scholar 

Diaz-Arrastia R, Kochanek PM, Bergold P, et al. Pharmacotherapy of traumatic brain injury: state of the science and the road forward: report of the Department of Defense Neurotrauma Pharmacology Workgroup. J Neurotrauma. 2014;31:135–58.

Article  PubMed  PubMed Central  Google Scholar 

Kochanek PM, Jackson TC, Ferguson NM, et al. Emerging therapies in traumatic brain injury. Semin Neurol. 2015;35:83–100.

Article  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif