*Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, Canada;

†BC Children's Hospital Research Institute, Vancouver, Canada;

‡Audiology and Speech Pathology Department, BC Children's Hospital, Vancouver, British Columbia, Canada;

§Division of Oncology, Hematology and Bone Marrow Transplant, British Columbia Children's Hospital and University of British Columbia, Vancouver, British Columbia, Canada;

¶Department of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands;

║Department of Pediatric Oncology, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, the Netherlands;

**Department of Biostatistics, Dalla Lana School of Public Health, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada;

††Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia;

‡‡Department of Anesthesiology, Pharmacology & Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada;

§§Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Canada; and

¶¶Pharmaceutical Outcomes Programme, British Columbia Children's Hospital, Vancouver, Canada.

Correspondence: Dr. Bruce C. Carleton, PharmD, 950 West 28th Avenue, Vancouver, British Columbia V5Z 4H4 (e-mail: [email protected]).

This study was partly supported by a grant from GenomeCanada, Genome British Columbia (funding #272PGX), and the Canadian Institutes of Health Research (CIHR) (funding #GP1-155872) through the Large-Scale Applied Research Project Competition. Additional support was provided by the British Columbia's Provincial Health Services Authority (PHSA), BC Children's Hospital Foundation, Health Canada, Illumina, and Thermo Fisher. Angela Siemens was also supported by CIHR's MSc Studentship and Drug Safety and Effectiveness Cross-Disciplinary Training programs.

The authors declare no conflict of interest.

Author contributions: Conceptualization, A.S. and B.C.C.; methodology, A.S.; data curation, A.S.; investigation, A.S., B.B., B.C.C.; formal analysis, A.S.; visualization, A.S.; writing—original draft preparation, A.S.; writing—review and editing, A.S., B.B., S.R.R., A.J.M.M., M.M.v.d.H., W.X., C.M.L., C.J.D.R, B.C.C.; supervision, B.C.C. All authors have read and agreed to the published version of the manuscript.