aEmory University School of Medicine, Atlanta, GA, USA
bDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
cDepartment of Otolaryngology, Emory University School of Medicine, Atlanta, GA, USA
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Article / Publication DetailsFirst-Page Preview
Received: October 05, 2021
Accepted: May 05, 2022
Published online: November 01, 2022
Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0
ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)
For additional information: https://www.karger.com/ORL
AbstractPrimary osteosarcomas are rarely seen in areas other than bone, although they can occur in sites such as the thigh, anal region, hand, etc. We present a case of primary extraskeletal osteosarcoma of the thyroid, of which there are only 29 previous reported cases. Presentations and treatment options for this type of tumor vary. Through this case report, we discuss the similarities and differences of the patient’s presentation compared with other documented cases, imaging, the rationale behind treatment, and the current clinical course.
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References Saadaat R, Abdul-Ghafar J, Ud Din N, Haidary AM. Anal extraskeletal osteosarcoma in a man: a case report and review of the literature. J Med Case Rep. 2020 Apr 20 [cited 2021 May 16];14(1):51. Hui J, Zhao Y, Zhang L, Lin J, Zhao H. Primary orbital extraskeletal osteosarcoma and review of literature. BMC Ophthalmol. 2020 Oct 22;20(1):425. Curfman KR, Morrissey SL. Extraskeletal osteosarcoma recognized following acute traumatic injury. Case Rep Oncol. 2019 Jan–Apr;12(1):282–8. Olgyai G, Horváth V, Banga P, Kocsis J, Buza N, Oláh A. Extraskeletal osteosarcoma located to the gallbladder. HPB. 2006;8(1):65–6. Casey DL, van de Rijn M, Riley G, Tung KW, Mohler DG, Donaldson SS. Extraskeletal osteosarcoma of the hand: the role of marginal excision and adjuvant radiation therapy. Hand. 2015 Dec;10(4):602–6. Bane BL, Evans HL, Ro JY, Carrasco CH, Grignon DJ, Benjamin RS, et al. Extraskeletal osteosarcoma. A clinicopathologic review of 26 cases. Cancer. 1990 Jun 15;65(12):2762–70. Makis W, Novales-Diaz J-A, Hickeson M. Primary thyroid osteosarcoma: staging and evaluation of response to therapy with F-18 FDG PET-CT. Clin Nucl Med. 2010 Jul;35(7):517–20. Salomão DR, Schmitt NJ, Wenger DE, Schlafmann S, Fritchie K. Extraskeletal osteosarcoma: a rare case arising in phthisis bulbi with a review of the literature. Ocul Oncol Pathol. 2019 Feb;5(2):114–8. Mc Auley G, Jagannathan J, O’Regan K, Krajewski KM, Hornick JL, Butrynski J, et al. Extraskeletal osteosarcoma: spectrum of imaging findings. Am J Roentgenol. 2012 Jan 1;198(1):W31–7. McCarter MD, Lewis JJ, Antonescu CR, Brennan MF. Extraskeletal osteosarcoma: analysis of outcome of a rare neoplasm. Sarcoma. 2000 Sep;4(3):119–23. Luo J, McManus C, Chen H, Sippel RS. Are there predictors of malignancy in patients with multinodular goiter? J Surg Res. 2012 May 15;174(2):207–10. Apostolou K, Zivaljevic V, Tausanovic K, Zoric G, Chelidonis G, Slijepcevic N, et al. Prevalence and risk factors for thyroid cancer in patients with multinodular goitre. BJS Open. 2021;5(2):zraa014. Choi LE, Healey JH, Kuk D, Brennan MF. Analysis of outcomes in extraskeletal osteosarcoma: a review of fifty-three cases. J Bone Joint Surg Am. 2014 Jan 1;96(1):e2. Puranik AD, Purandare NC, Bal MM, Shah S, Agrawal A, Rangarajan V. Extraskeletal osteosarcoma: an uncommon variant with rare metastatic sites detected with FDG PET/CT. Indian J Med Paediatr Oncol. 2014;35(1):96–8. Nitzsche EU, Seeger LL, Klosa B, Freudenberg N, Moser EA. Primary osteosarcoma of the thyroid gland. J Nucl Med. 1992 Jul;33(7):1399–401. Nystrom LM, Reimer NB, Reith JD, Scarborough MT, Gibbs CP. The treatment and outcomes of extraskeletal osteosarcoma: institutional experience and review of the literature. Iowa Orthop J. 2016;36:98–103. Paludo J, Fritchie K, Haddox CL, Rose PS, Arndt CAS, Marks RS, et al. Extraskeletal osteosarcoma: outcomes and the role of chemotherapy. Am J Clin Oncol. 2018 Sep;41(9):832–7. Liao Z, Qiu M, Yang J, Yang Y, Zhu L, Yang B, et al. Outcomes of surgery and/or combination chemotherapy for extraskeletal osteosarcoma: a single-center retrospective study from China. Sci Rep. 2019 Mar 18;9(1):4816. Heng M, Gupta A, Chung PW, Healey JH, Vaynrub M, Rose PS, et al. The role of chemotherapy and radiotherapy in localized extraskeletal osteosarcoma. Eur J Cancer Oxf Engl. 2020 Jan;125:130–41. Article / Publication DetailsFirst-Page Preview
Received: October 05, 2021
Accepted: May 05, 2022
Published online: November 01, 2022
Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0
ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)
For additional information: https://www.karger.com/ORL
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