Title: Deputy Director of the Department, a former youth member of the Chinese Medical Association Nephrology Branch, currently a member of the Chinese Physicians Association Integrated Nephrology Committee, member of the Renal Pathology Committee of the Chinese Association of Nonpublic Medical Institutions Nephrology Dialysis Specialty Committee, standing member and secretary of the Hebei Medical Association Nephrologist Branch, member of the Hebei Medical Association Osteoporosis and Bone Mineral Salt Branch, Hebei Nephrology Prevention and Control Chairman of the Supervisory Committee of the Society, Standing Member and Secretary of the Nephrology Branch of Shijiazhuang Medical Association

Research interests: diagnosis and treatment of glomerular diseases, nutrition therapy for kidney disease

There are 3437 words in our manuscript except for references, tables, and figures.

Short titles as headings

A high protein diet (HPD) and CKD

Low Protein Diet in the management of CKD

The quality of different protein

The plant-dominant low-protein diet (PLADO)

The PLADO in the protection of CKD

●Regulation of intestinal flora

●Regulate acid-base balance

●Control of blood lipids, blood pressure, and cardiovascular disease

●Effect on blood phosphorus, potassium, and mortality

●Remaining possible mechanisms of benefit for CKD patients

The existing problem in PLADO

●Malnutrition

●Risk of sarcopenia

●Impact on quality of life

●Deficiencies of some micronutrients

●Challenges of implementations

Support and financial disclosure Declaration

Funding This work was supported by the Hebei Provincial Health

Commission(2021). It Provides funding for finding papers.

Acknowledgments Not applicable.

Authorship

Competing interests The authors declare that they have no conflict of interest.

Authors' contributions YC and JL, W participated in writing, MD,L, and DY helped draft the manuscript. All authors have read and approved the manuscript.