Title:Comparison between Kidney and Liver Transplant Recipients Admitted to a Referral Center Regarding Coronavirus-2019 Manifestations in the Northeast of Iran during three Peaks of Pandemic

VOLUME: 17 ISSUE: 4

Author(s):Mohsen Aliakbarian, Rozita Khodashahi *, Mahin Ghorban Sabbagh, Hamid Reza Naderi , Mandana Khodashahi , Shahrzad Jahanian and Maliheh Dadgar Moghaddam

Affiliation:Associate Professor of Hepatopancreatobiliary & Transplant Surgery, Surgical Oncology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Assistant Professor of Infectious Diseases, Fellowship in IC host & transplant, Department of Infectious Diseases and Tropical Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Assistant Professor of Nephrology, Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Professor of Infectious Diseases, Department of Infectious Diseases and Tropical Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Assistant Professor of Rheumatology, Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Resident of Infectious Diseases, Department of Infectious Diseases and Tropical Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Associate Professor of Community Medicine, Department of Community Medicine, Faculty of Medicine,Mashhad University of Medical Sciences, Mashhad

Keywords:COVID-19, consolidation, immunosuppressive, mortality, renal, transplantation.

Abstract:

Background: Transplant recipients are at high risk for severe Coronavirus disease-2019 (COVID-19). Transplant recipients are immune-compromised individuals at high risk for severe infection. This study aimed to compare the presentations and outcomes of liver and kidney transplant recipients who were infected with COVID-19 in the Iranian population.

Methods: This cross-sectional study was conducted at Imam Reza and Montaserieh Hospitals affiliated with Mashhad University of Medical Sciences, Mashhad, Iran, between 2020 and 2021. In general, 52 patients were selected and divided into two groups of the kidney (n=28) and liver (n=24) transplantation. Two groups were compared in terms of demographic characteristics and clinical findings.

Results: Of the 52 patients, severe COVID-19 infection was reported in 61% of the patients. There was no significant difference between the two groups in terms of symptoms, except for cough (χ2=8.09; P=0.004), clinical condition, and laboratory symptoms, except for creatinine (Z=14; P0.05). All patients with kidney transplantation survived, while two cases in the liver transplantation group failed to survive (χ2=2.42; P=0.11).

Conclusion: The mortality rate was higher in the liver transplant recipients, compared to the patients who underwent kidney transplantation.