1. Knolle, PA, Gerken, G. Local control of the immune response in the liver. Immunol Rev 2000; 174: 21–34.
Google Scholar | Crossref | Medline | ISI2. Heymann, F, Tacke, F. Immunology in the liver–from homeostasis to disease. Nat Rev Gastroenterol Hepatol 2016; 13: 88–110.
Google Scholar | Crossref | Medline | ISI3. European Food Safety Authority . Opinion of the scientific panel on contaminants in the food chain on a request from the commission related to deoxynivalenol (DON) as undesirable substance in animal feed. EFSA J 2004; 73: 1–42.
Google Scholar4. European Food Safety Authority . Scientific Report of EFSA - Deoxynivalenol in food and feed: occurrence and exposure. EFSA J 2013; 11: 3379.
Google Scholar5. Pinton, P, Braicu, C, Nougayrede, JP, et al. Deoxynivalenol impairs porcine intestinal barrier function and decreases the protein expression of claudin-4 through a mitogen-activated protein kinase-dependent mechanism. J Nutr 2010; 140: 1956–1962.
Google Scholar | Crossref | Medline6. Bracarense, AP, Lucioli, J, Grenier, B, et al. Chronic ingestion of deoxynivalenol and fumonisin, alone or in interaction, induces morphological and immunological changes in the intestine of piglets. Br J Nutr 2012; 107: 1776–1786.
Google Scholar | Crossref | Medline7. Pinton, P, Nougayrede, JP, Del Rio, JC, et al. The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression. Toxicol Appl Pharmacol 2009; 237: 41–48.
Google Scholar | Crossref | Medline8. Klunker, LR, Kahlert, S, Panther, P, et al. Deoxynivalenol and E. coli lipopolysaccharide alter epithelial proliferation and spatial distribution of apical junction proteins along the small intestinal axis. J Anim Sci 2012; 90: 276–285.
Google Scholar9. Dänicke, S, Brosig, B, Klunker, LR, et al. Systemic and local effects of the Fusarium toxin deoxynivalenol (DON) are not alleviated by dietary supplementation of humic substances (HS). Food Chem Toxicol 2012; 50: 979–988.
Google Scholar | Crossref | Medline10. Kahlert, S, Renner, L, Kluess, J, et al. Effects of deoxynivalenol-feed contamination on circulating LPS in pigs. Innate Immun 2019; 25: 168–175.
Google Scholar | SAGE Journals | ISI11. Tesch, T, Bannert, E, Kluess, J, et al. Relationships between body temperatures and inflammation indicators under physiological and pathophysiological conditions in pigs exposed to systemic lipopolysaccharide and dietary deoxynivalenol. J Anim Physiol Anim Nutr (Berl) 2018; 102: 241–251.
Google Scholar | Crossref | Medline12. Tesch, T, Bannert, E, Kluess, J, et al. Does dietary deoxynivalenol modulate the acute phase reaction in endotoxaemic pigs? Lessons from clinical signs, white blood cell counts, and TNF-alpha. Toxins 2016; 8.
Google Scholar13. Dänicke, S, Brezina, U. Invited Review: Kinetics and metabolism of the Fusarium toxin deoxynivalenol in farm animals: Consequences for diagnosis of exposure and intoxication and carry over. Food Chem Toxicol 2013; 60: 58–75.
Google Scholar | Crossref | Medline14. Renner, L, Kahlert, S, Tesch, T, et al. Chronic DON exposure and acute LPS challenge: Effects on porcine liver morphology and function. Mycotoxin Res 2017; 33: 207–218.
Google Scholar | Crossref | Medline15. Stanek, C, Reinhardt, N, Diesing, AK, et al. A chronic oral exposure of pigs with deoxynivalenol partially prevents the acute effects of lipopolysaccharides on hepatic histopathology and blood clinical chemistry. Toxicol Lett 2012; 215: 193–200.
Google Scholar | Crossref | Medline16. Grenier, B, Loureiro-Bracarense, AP, Lucioli, J, et al. Individual and combined effects of subclinical doses of deoxynivalenol and fumonisins in piglets. Mol Nutr Food Res 2011; 55: 761–771.
Google Scholar | Crossref | Medline17. European Commission . Commission recommendation of 17 August 2006 on the presence of deoxynivalenol, zearalenone, ochratoxin A, T-2 and HT-2 and fumonisins in products intended for animal feeding. Official Journal of the European Union 2006; 229: 7–9.
Google Scholar18. Bannert, E, Tesch, T, Kluess, J, et al. Plasma kinetics and matrix residues of deoxynivalenol (DON) and zearalenone (ZEN) are altered in endotoxaemic pigs independent of LPS entry site. Mycotoxin Res 2017; 33: 183–195.
Google Scholar | Crossref | Medline19. Bannert, E, Tesch, T, Kluess, J, et al. Metabolic and hematological consequences of dietary deoxynivalenol interacting with systemic Escherichia coli lipopolysaccharide. Toxins 2015; 7: 4773–4796.
Google Scholar | Crossref | Medline20. Aranda, PS, LaJoie, DM, Jorcyk, CL. Bleach gel: A simple agarose gel for analyzing RNA quality. Electrophoresis 2012; 33: 366–369.
Google Scholar | Crossref | Medline | ISI21. Freeman, TC, Ivens, A, Baillie, JK, et al. A gene expression atlas of the domestic pig. BMC Biol 2012; 10: 90.
Google Scholar | Crossref | Medline | ISI22. Edgar, R, Domrachev, M, Lash, AE. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 2002; 30: 207–210.
Google Scholar | Crossref | Medline | ISI23. Hadlich, F, Reyer, H, Oster, M, et al. rePROBE: Workflow for revised probe assignment and updated probe-set annotation in microarrays. Genom Proteom Bioinform 2021. DOI: 10.1016/j.gpb.2020.06.007.
Google Scholar | Crossref | Medline24. Carvalho, BS, Irizarry, RA. A framework for oligonucleotide microarray preprocessing. Bioinformatics 2010; 26: 2363–2367.
Google Scholar | Crossref | Medline25. Kauffmann, A, Gentleman, R, Huber, W. arrayQualityMetrics–a bioconductor package for quality assessment of microarray data. Bioinformatics 2009; 25: 415–416.
Google Scholar | Crossref | Medline | ISI26. Bourgon, R, Gentleman, R, Huber, W. Independent filtering increases detection power for high-throughput experiments. Proc Natl Acad Sci USA 2010; 107: 9546–9551.
Google Scholar | Crossref | Medline | ISI27. Storey, JD, Tibshirani, R. Statistical significance for genomewide studies. Proc Natl Acad Sci U S A 2003; 100: 9440–9445.
Google Scholar | Crossref | Medline | ISI28. Oliveros JC . Venny. An interactive tool for comparing lists with Venn's diagrams. http://bioinfogp.cnb.csic.es/tools/venny/index.html (2007–2015, accessed 3 March 2019).
Google Scholar29. Huang, DW, Sherman, BT, Lempicki, RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009; 4: 44–57.
Google Scholar | Crossref | Medline | ISI30. Kassambara, A. ggpubr: ‘ggplot2' Based Publication Ready Plots 0.2.4, https://rpkgs.datanovia.com/ggpubr/ (2019, accessed January 2019).
Google Scholar31. Plotly Technologies Inc. plotly: Collaborative data science ., https://plot.ly (2015, accessed January 2019).
Google Scholar32. RStudio Team . RStudio: Integrated Development Environment for R., http://www.rstudio.com/ (2020).
Google Scholar33. Dänicke, S, Bannert, E, Tesch, T, et al. Oral exposure of pigs to the mycotoxin deoxynivalenol does not modulate the hepatic albumin synthesis during a LPS-induced acute-phase reaction. Innate Immun 2020; 26: 716–732.
Google Scholar | SAGE Journals34. Ye, J, Coulouris, G, Zaretskaya, I, et al. Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction. BMC Bioinform 2012; 13: 134.
Google Scholar | Crossref | Medline | ISI35. Chen, F, Liu, Y, Zhu, H, et al. Fish oil attenuates liver injury caused by LPS in weaned pigs associated with inhibition of TLR4 and nucleotide-binding oligomerization domain protein signaling pathways. Innate Immun 2013; 19: 504–515.
Google Scholar | SAGE Journals | ISI36. Liu, Z, Liu, W, Huang, Y, et al. Lipopolysaccharide significantly influences the hepatic triglyceride metabolism in growing pigs. Lipids Health Dis 2015; 14: 64.
Google Scholar | Crossref | Medline37. Moon, Y, Pestka, JJ. Deoxynivalenol-induced mitogen-activated protein kinase phosphorylation and IL-6 expression in mice suppressed by fish oil. J Nutr Biochem 2003; 14: 717–726.
Google Scholar | Crossref | Medline | ISI38. Pestka, JJ. Deoxynivalenol: Toxicity, mechanisms and animal health risks. Anim Feed Sci Technol 2007; 137: 283–298.
Google Scholar | Crossref | ISI39. Pestka, JJ. Deoxynivalenol-induced proinflammatory gene expression: Mechanisms and pathological sequelae. Toxins 2010; 2: 1300–1317.
Google Scholar | Crossref | Medline40. Zhou, HR, Jia, Q, Pestka, JJ. Ribotoxic stress response to the trichothecene deoxynivalenol in the macrophage involves the SRC family kinase Hck. Toxicol Sci 2005; 85: 916–926.
Google Scholar | Crossref | Medline41. Zhou, HR, Lau, AS, Pestka, JJ. Role of double-stranded RNA-activated protein kinase R (PKR) in deoxynivalenol-induced ribotoxic stress response. Toxicol Sci 2003; 74: 335–344.
Google Scholar | Crossref | Medline42. Zhou, HR, Islam, Z, Pestka, JJ. Induction of competing apoptotic and survival signaling pathways in the macrophage by the ribotoxic trichothecene deoxynivalenol. Toxicol Sci 2005; 87: 113–122.
Google Scholar | Crossref | Medline43. Amuzie, CJ, Shinozuka, J, Pestka, JJ. Induction of suppressors of cytokine signaling by the trichothecene deoxynivalenol in the mouse. Toxicol Sci 2009; 111: 277–287.
Google Scholar | Crossref | Medline44. Chung, YJ, Zhou, HR, Pestka, JJ. Transcriptional and posttranscriptional roles for p38 mitogen-activated protein kinase in up-regulation of TNF-alpha expression by deoxynivalenol (vomitoxin). Toxicol Appl Pharmacol 2003; 193: 188–201.
Google Scholar | Crossref | Medline45. Greene, DM, Azcona-Olivera, JI, Pestka, JJ. Vomitoxin (deoxynivalenol)-induced IgA nephropathy in the B6C3F1 mouse: Dose response and male predilection. Toxicology 1994; 92: 245–260.
Google Scholar | Crossref | Medline46. Azcona-Olivera, JI, Ouyang, Y, Murtha, J, et al. Induction of cytokine mRNAs in mice after oral-exposure to the trichothecene vomitoxin (deoxynivalenol): Relationship to toxin distribution and protein-synthesis inhibition. Toxicol Appl Pharmacol 1995; 133: 109–120.
Google Scholar | Crossref | Medline47. Greene, DM, Bondy, GS, Azcona-Olivera, JI, et al. Role of gender and strain in vomitoxin-induced dysregulation of IgA production and IgA nephropathy in the mouse. J Toxicol Environ Health 1994; 43: 37–50.
Google Scholar | Crossref | Medline48. Döll, S, Dänicke, S. The Fusarium toxins deoxynivalenol (DON) and zearalenone (ZON) in animal feeding. Prev Vet Med 2011; 102: 132–145.
Google Scholar | Crossref | Medline49. Ganey, PE, Roth, RA. Concurrent inflammation as a determinant of susceptibility to toxicity from xenobiotic agents. Toxicology 2001; 169: 195–208.
Google Scholar | Crossref | Medline | ISI50. Islam, Z, Moon, YS, Zhou, HR, et al. Endotoxin potentiation of trichothecene-induced lymphocyte apoptosis is mediated by up-regulation of glucocorticoids. Toxicol Appl Pharmacol 2002; 180: 43–55.
Google Scholar | Crossref | Medline51. Islam, Z, Pestka, JJ. LPS priming potentiates and prolongs proinflammatory cytokine response to the trichothecene deoxynivalenol in the mouse. Toxicol Appl Pharmacol 2006; 211: 53–63.
Google Scholar |